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Multiwalled carbon nanotubes display microtubule biomimetic properties in vivo, enhancing microtubule assembly and stabilization

Abstract: Microtubules are hollow protein cylinders of 25 nm diameter which are implicated in cytokinetics and proliferation in all eukaryotic cells. Here we demonstrate in vivo how multiwalled carbon nanotubes (MWCNTs) interact with microtubules in human cancer cells (HeLa) blocking mitosis and leading to cell death by apoptosis. Our data suggest that, inside the cells, MWCNTs display microtubule biomimetic properties, assisting and enhancing noncentrosomal microtubule polymerization and stabilization. These features might be useful for developing a revolutionary generation of chemotherapeutic agents based on nanomaterials.

 Fuente: ACS Nano, 2012, 6(8), 6614-6625

 Editorial: American Chemical Society

 Año de publicación: 2012

 Nº de páginas: 12

 Tipo de publicación: Artículo de Revista

 DOI: 10.1021/nn302222m

 ISSN: 1936-0851,1936-086X

 Proyecto español: MAT2011-28868-C02-01

 Url de la publicación: https://doi.org/10.1021/nn302222m

Autoría

LIDIA RODRIGUEZ FERNANDEZ

JESUS ANTONIO GONZALEZ GOMEZ

FANARRAGA, MÓNICA L.