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A self-assembled subphthalocyanine-based nanophotosensitiser for photodynamic therapy

Abstract: A subphthalocyanine substituted with nine tetra(ethylene glycol) chains on the periphery has been synthesised. This novel amphiphilic and cone-shaped compound can self-assemble in water into spherical nanoparticles with a hydrodynamic diameter of 154 nm. These nanoparticles can be taken up readily by cancer cells and localised predominately in lysosomes where they disassemble gradually, leading to activation in fluorescence emission and, photocytotoxicity, showing IC50 values of as low as 1.2 uM.

 Autoría: Casellas N.M., Dai G., Xue E.Y., Fonseca A., Ng D.K.P., García-Iglesias M., Torres T.,

 Fuente: Chemical Communications, 2022, 58(5), 669-672

 Editorial: Royal Society of Chemistry

 Fecha de publicación: 16/01/2022

 Nº de páginas: 4

 Tipo de publicación: Artículo de Revista

 DOI: 10.1039/d1cc05977g

 ISSN: 1359-7345,1364-548X

 Proyecto español: PID2020-116490GB-I00

 Url de la publicación: https://doi.org/10.1039/D1CC05977g

Autoría

MUÑOZ CASELLAS, NICOLÁS

DAI, GAOLE

XUE, EVELYN Y.

FONSECA CRESPO, ALBA

NG, DENNIS KEE PUI

TORRES CEBADA, TOMÁS