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Molecular characterization of multidrug resistant Enterobacterales strains isolated from liver and kidney transplant recipients in Spain

Abstract: The objective of this study was to analyse the mechanisms of resistance to carbapenems and other extended-spectrum-?-lactams and to determine the genetic relatedness of multidrug-resistant Enterobacterales (MDR-E) causing colonization or infection in solid-organ transplantation (SOT) recipients. Prospective cohort study in kidney (n= 142), liver (n= 98) or kidney/pancreas (n= 7) transplant recipients between 2014 and 2018 in seven Spanish hospitals. We included 531 MDR-E isolates from rectal swabs obtained before transplantation and weekly for 4?6 weeks after the procedure and 10 MDR-E from clinical samples related to an infection. Overall, 46.2% Escherichia coli, 35.3% Klebsiella pneumoniae, 6.5% Enterobacter cloacae, 6.3% Citrobacter freundii and 5.7% other species were isolated. The number of patients with MDR-E colonization post-transplantation (176; 71.3%) was 2.5-fold the number of patients colonized pre-transplantation (71; 28.7%). Extended spectrum ?-lactamases (ESBLs) and carbapenemases were detected in 78.0% and 21.1% of MDR-E isolates respectively. In nine of the 247 (3.6%) transplant patients, the microorganism causing an infection was the same strain previously cultured from surveillance rectal swabs. In our study we have observed a low rate of MDR-E infection in colonized patients 4?6 weeks post-transplantation. E. coli producing blaCTX-M-G1 and K. pneumoniae harbouring blaOXA-48 alone or with blaCTX-M-G1 were the most prevalent MDR-E colonization strains in SOT recipients.

 Fuente: Scientifc Reports (2021) 11:11875

 Editorial: Nature Publishing Group

 Fecha de publicación: 04/06/2021

 Nº de páginas: 9

 Tipo de publicación: Artículo de Revista

 DOI: doi.org/10.1038/s41598-021-90382-5

 ISSN: 2045-2322

 Proyecto español: REIPI RD16/0016/0007, RD16/0016/0010, RD16/0016/0012, RD16/0016/0011, RD16/0016/0008, RD16/0016/0002

 Url de la publicación: https://doi.org/10.1038/s41598-021-90382-5

Autoría

MARTA FERNANDEZ MARTINEZ

GONZÁLEZ RICO, CLAUDIA

MONICA GOZALO MARGÜELLO

MARCO, FRANCESC

GRACIA AHUFNGER, IRENE

ARANZAMENDI, MAITANE

SÁNCHEZ DÍAZ, ANA M.

VICENTE RANGEL, TERESA

CHAVES, FERNANDO

JORGE CALVO MONTES

MARTÍNEZ MARTÍNEZ, LUIS