Buscar

Estamos realizando la búsqueda. Por favor, espere...

CD3e recruits Numb to promote TCR degradation

Abstract: Modulation of TCR signaling upon ligand binding is achieved by changes in the equilibrium between TCR degradation, recycling and synthesis; surprisingly, the molecular mechanism of such an important process is not fully understood. Here, we describe the role of a new player in the mediation of TCR degradation: the endocytic adaptor Numb. Our data show that Numb inhibition leads to abnormal intracellular distribution and defective TCR degradation in mature T lymphocytes. In addition, we find that Numb simultaneously binds to both Cbl and a site within CD3e that overlaps with the Nck binding site. As a result, Cbl couples specifically to the CD3e chain to mediate TCR degradation. The present study unveils a novel role of Numb that lies at the heart of TCR signaling initiation and termination

 Fuente: International Immunology, 2016, 28(3), 127-137

 Editorial: Oxford University Press

 Año de publicación: 2015

 Nº de páginas: 11

 Tipo de publicación: Artículo de Revista

 DOI: 10.1093/intimm/dxv060

 ISSN: 0953-8178,1460-2377

 Url de la publicación: https://doi.org/10.1093/intimm/dxv060

Autoría

MARTÍN BLANCO, NADIA

JIMÉNEZ TEJA, DANIEL

GABRIEL BRETONES SANCHEZ

BORROTO, ALDO

CARABALLO, MICHAEL

SCREPANTI, ISABELLA

ALARCÓN, BALBINO

CANELLES, MATILDE