Distinguishing psychomimetic from antidepressant-like effects in mice using molecular and electrophysiological biomarkers

Merino E, Cervera-Ferri A, Lanuza E, Cabanu S, Pilar-Cuéllar F, Adell A, Teruel-Martí V, Martínez-Ricós J.

​Eur J Pharmacol. 2026 Jul 10;1029:178994.​​​

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What value do NMDA receptor antagonist models of schizophrenia have for novel drug discovery?

Adell A.

​Expert Opin Drug Discov. 2025 Nov;20(11):1377-1385.​​​

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Sex differences in the modulation of anxiety- and depression-like behaviors by matrix metalloproteinase-9 expression levels in mice.

Senserrich J, Castro E, Florensa-Zanuy E, Díaz Á, Pazos Á, Adell A, Tzinia A, Pilar-Cuéllar F.

​Biol Sex Differ. 2025 May 22;16(1):34. ​

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A combination of Δ9-tetrahydrocannabinol and cannabidiol modulates glutamate dynamics in the hippocampus of an animal model of Alzheimer's disease

Sánchez-Fernández N, Gómez-Acero L, Castañé A, Adell A, Campa L, Bonaventura J, Brito V, Ginés S, Queiróz F, Silva H, Lopes JP, Lopes CR, Radošević M, Gasull X, Cunha RA, Köfalvi A, Ferreira SG, Ciruela F, Aso E.

​Neurotherapeutics. 2024 Sep;21(5):e00439.​

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Population Pharmacokinetic-Pharmacodynamic Analysis of a Reserpine-Induced Myalgia Model in Rats

Alfosea-Cuadrado GM, Zarzoso-Foj J, Adell A, Valverde-Navarro AA, González-Soler EM, Mangas-Sanjuán V, Blasco-Serra A.

​Pharmaceutics. 2024 Aug 21;16(8):1101.

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Characterization of the Antitumor Potential of Extracts of Cannabis sativa Strains with High CBD Content in Human Neuroblastoma

Sánchez-Sánchez L, García J, Fernández R, Noskova E, Egiguren-Ortiz J, Gulak M, Ochoa E, Laso A, Oiarbide M, Santos JI, Fe Andrés M, González-Coloma A, Adell A, Astigarraga E, Barreda-Gómez G.

​Int J Mol Sci. 2023 Feb 14;24(4):3837.​
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Acute Stress-Induced Changes in the Lipid Composition of Cow's Milk in Healthy and Pathological Animals

Garro-Aguilar Y, Fernández R, Calero S, Noskova E, Gulak M, de la Fuente M, Adell A, Simón E, Muzquiz U, Rodríguez-Piñón D, Astigarraga E, Barreda-Gómez G.

​Molecules. 2023 Jan 18;28(3):980.​​​

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Screening System of Cannabis sativa Extracts Based on Their Mitochondrial Safety Profile Using Cytochrome c Oxidase Activity as a Biomarker

Noskova E, Fernández R, García J, Ochoa E, Domínguez-Fernández C, Adell A, Laso A, Andrés MF, González-Coloma A, Astigarraga E, Barreda-Gómez G.

Int J Mol Sci​​. 2023 Jan 10;24(2):1315.​
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Molecular Signaling Mechanisms for the Antidepressant Effects of NLX-101, a Selective Cortical 5-HT 1A Receptor Biased Agonist

Cabanu S, Pilar-Cuéllar F, Zubakina P, Florensa-Zanuy E, Senserrich J, Newman-Tancredi A, Adell A.

Pharmaceuticals (Basel). 2022 Mar 10;15(3):337.

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Effects of Acute Stress on the Oscillatory Activity of the Hippocampus-Amygdala-Prefrontal Cortex Network

Merino E, Raya-Salom D, Teruel-Martí V, Adell A, Cervera-Ferri A, Martínez-Ricós J.

Neuroscience. 2021 Sep 17:S0306-4522(21)00476-0. doi: 10.1016/j.neuroscience.2021.09.009. Online ahead of print.

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mTOR Knockdown in the Infralimbic Cortex Evokes A Depressive-like State in Mouse

Garro-Martínez E, Fullana MN, Florensa-Zanuy E, Senserrich J, Paz V, Ruiz-Bronchal E, Adell A, Castro E, Díaz Á, Pazos Á, Bortolozzi A, Pilar-Cuéllar F.

​Int J Mol Sci. 2021 Aug 12;22(16):8671. doi: 10.3390/ijms22168671.

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Structural connectivity and subcellular changes after antidepressant doses of ketamine and Ro 25-6981 in the rat: an MRI and immuno-labeling study

Pascual-Antón R, Blasco-Serra A, Muñoz-Moreno E, Pilar-Cuéllar F, Garro-Martínez E, Florensa-Zanuy E, López-Gil X, Campa VM, Soria G, Adell A.

​Brain Struct Funct. 2021 Aug 7. doi: 10.1007/s00429-021-02354-0.

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Structural connectivity and subcellular changes after antidepressant doses of ketamine and Ro 25-6981 in the rat

Pascual-Antón R, Blasco-Serra A, Muñoz-Moreno E, Pilar-Cuéllar F, Garro-Martínez E, Florensa-Zanuy E, López-Gil X, Campa VM, Soria G, Adell A.

Brain Struct Funct. 2021 Nov;226(8):2603-2616. 

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Cannabidiol antidepressant-like effect in the lipopolysaccharide model in mice: Modulation of inflammatory pathways

Florensa-Zanuy E, Garro-Martínez E, Adell A, Castro E, Díaz Á, Pazos Á, Mac-Dowell KS, Martín-Hernández D, Pilar-Cuéllar F.

​Biochem Pharmacol. 2021 Mar;185:114433. doi: 10.1016/j.bcp.2021.114433. Epub 2021 Jan 26.

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Role of Serotonin and Noradrenaline in the Rapid Antidepressant Action of Ketamine.

López-Gil X, Jiménez-Sánchez L, Campa L, Castro E, Frago C, Adell A.

​ACS Chem Neurosci. 2019 Jul 17;10(7):3318-3326. doi: 10.1021/acschemneuro.9b00288. Epub 2019 Jun 18.​

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β-Catenin Role in the Vulnerability/Resilience to Stress-Related Disorders Is Associated to Changes in the Serotonergic System.

Garro-Martínez E, Vidal R, Adell A, Díaz Á, Castro E, Amigó J, Gutiérrez-Lanza R, Florensa-Zanuy E, Gómez-Acero L, Taketo MM, Pazos Á, Pilar-Cuéllar F.

Mol Neurobiol. 2019 Dec 10. doi: 10.1007/s12035-019-01841-0. [Epub ahead of print]

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Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist.

Gordillo-Salas M, Pilar-Cuéllar F, Auberson YP, Adell A.

​Transl Psychiatry. 2018 Apr 18;8(1):84. doi: 10.1038/s41398-018-0131-9.​

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Behavioral, neurochemical and molecular changes after acute deep brain stimulation of the infralimbic prefrontal cortex.

Jiménez-Sánchez L, Linge R, Campa L, Valdizán EM, Pazos Á, Díaz Á, Adell A.

Neuropharmacology. 2016 Sep;108:91-102.​

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Characterization of oscillatory changes in hippocampus and amygdala after deep brain stimulation of the infralimbic prefrontal cortex.

Cervera-Ferri A, Teruel-Martí V, Barceló-Molina M, Martínez-Ricós J, Luque-García A, Martínez-Bellver S, Adell A.

​[PubMed] Physiol Rep. 2016 Jul;4(14). pii: e12854. doi: 10.14814/phy2.12854.

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Activation of AMPA Receptors Mediates the Antidepressant Action of Deep Brain Stimulation of the Infralimbic Prefrontal Cortex.

Jiménez-Sánchez L, Castañé A, Pérez-Caballero L, Grifoll-Escoda M, López-Gil X, Campa L, Galofré M, Berrocoso E, Adell A.

Cereb Cortex. 2016 Jun;26(6):2778-89.​ ​[PubMed]

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Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors.

Linge R, Jiménez-Sánchez L, Campa L, Pilar-Cuéllar F, Vidal R, Pazos A, Adell A, Díaz Á. Neuropharmacology. 2016 Apr;103:16-26. doi: 10.1016/j.neuropharm.2015.12.017.

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Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors.

Linge R, Jiménez-Sánchez L, Campa L, Pilar-Cuéllar F, Vidal R, Pazos A, Adell A, Díaz Á.

​Neuropharmacology. 2016 Apr;103:16-26. doi: 10.1016/j.neuropharm.2015.12.017. Epub 2015 Dec 19.

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Revisiting the role of raphe and serotonin in neuropsychiatric disorders.

Adell A. (2015) J Gen Physiol 145: 257-259.

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The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression.

Jiménez-Sánchez L., Campa L., Auberson Y.P. and Adell A. (2014) Neuropsychopharmacology 39, 2673–2680.

​[PubMed]

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Expression of 5-HT2A receptors in prefrontal cortex pyramidal neurons projecting to nucleus accumbens. Potential relevance for atypical antipsychotic action.

Mocci G., Jiménez-Sánchez L., Adell A. and Artigas F. (2014) Neuropharmacology 79: 49-58.

​[PubMed]

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Blockade of MK-801-induced heat shock protein 72 in rat brain by antipsychotic and monoaminergic agents targeting D2, 5-HT1A, 5-HT2A and α1-adrenergic receptors.

Romón T., Planas A.M. and Adell A. (2014) CNS Neurol. Disord. – Drug Targets 13: 104-111.

​[PubMed]

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Role of prefrontal cortex in the pathophysiology and treatment of depression and schizophrenia. In: Neurobiology of Mood Disorders.

López-Gil X., Jiménez-Sánchez L. and Adell A. (2013) Guiard B.P. and Dremencov E. (Eds.). Bentham Science Publishers, Sharjah, pp. 139-173.

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Importance of interhemispheric prefrontal connection in the effects of noncompetitive NMDA receptor antagonists.

López-Gil X., Jiménez-Sánchez L., Romón T., Campa L., Artigas F. and Adell A. (2012) Int. J. Neuropsychopharmacol. 15: 945-956.

​[PubMed]

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Is the acute NMDA receptor hypofunction a valid model of schizophrenia?

Adell A., Jiménez-Sánchez L., López-Gil X. and Romón T. (2012) Schizophrenia Bull. 38: 9-14.

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Expression of parvalbumin and glutamic acid decarboxylase-67 after acute administration of MK-801. Implications for the NMDA hypofunction model of schizophrenia.

Romón T., Mengod G. and Adell A. (2011) Psychopharmacology 217: 231-238.

​[PubMed]

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Microdialysis.

Adell A. and Artigas F. (2010) In: Encyclopedia of Psychopharmacology. Stolerman I.P. (Ed.). Springer-Verlag, Berlin, pp. 769-775.

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Lu-AA21004, a multimodal serotonergic agent, for the potential treatment of depression and anxiety.

Adell A. (2010) Idrugs 13: 900-910.

​[PubMed]

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In vitro and in vivo activation of astrocytes by amyloid β is potentiated by pro-oxidant agents.

García-Matas S., de Vera N., Ortega-Aznar A., Marimon J.M., Adell A., Planas A.M., Cristòfol R. and Sanfeliu C. (2010) J. Alzheimer's Dis. 20: 229-245.

​[PubMed]

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Serotonin interaction with other transmitter systems. In: Handbook of Behavioral Neurobiology of Serotonin.

Adell A., Bortolozzi A., Díaz-Mataix L., Santana N. and Artigas F. (2010) Müller C.P. and Jacobs B.L. (Eds.). Elsevier, Amsterdam, pp. 259-276.

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Unraveling monoamine receptors involved in the action of typical and atypical antipsychotics on glutamatergic and serotonergic transmission in prefrontal cortex.

López-Gil X., Artigas F. and Adell A. (2010) Curr. Pharm. Des. 16: 502-515.

​[PubMed]

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New strategies in the search of antipsychotic drugs.

Adell A. (2010) Curr. Pharm. Des. 16: 486-487.

​[PubMed]

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