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 Detalle Investigador

JAVIER LEON SERRANO

  • Publicaciones

    21

  • Proyectos

    10

  • Tesis

    21

  • Patentes y tecnologías

    3

Javier León was Graduated in Biological Sciences and Graduated in Pharmacy in the University Complutense, Madrid. He also holds the title of Specialist in Microbiology (FIR, Hospital Marqués de Valdecilla, Santander). He defended in 1983 the PhD Thesis on antibiotic resistance in the University of Cantabria (UC), and did a postdoctoral research (1984- 1986) in New York University Cancer Center. In 1986 he got the position of “Profesor Titular” of Biochemistry and Molecular Biology in the UC and in 1994 that of “Catedrático”. Since 1988 J. León leads a research group and in 2007 he moved to the Instituto de Biomedicina y Biotecnología (IBBTEC), a joint center CSIC-UC.

Research activity

Dr. León’s group has been funded by the Plan Estatal de I+D, being the PI in 10 consecutive grants, and of a few local grants. He has spent as visiting scientist a total of 2.5 years in Fred Hutchinson Cancer Research Center (Seattle) and Dana Farber Cancer Institute/Harvard Cancer Center (Boston).

He has supervised 21 PhD Thesis and published 94 research papers in indexed journals, being first or corresponding author in 62 of them. His H-index is 36 (Google Scholar) or 33 (Scopus) with more than 3450 citations (Scopus). Since 2010 he has published 24 research papers. He has six research “sexenios” (last 2013-18)

His research interests over the last 20 years have been:

a) MYC oncogene in cell cycle and the mechanisms by which MYC accelerates the cell cycle and produces the inhibition of p53 and p27 activities (Ceballos et al. 2000. Ceballos et al. 2005; Acosta et al, 2008), discovery of SKP2 as a new MYC target gene (Bretones, 2015) and the mechanisms by which MYC induces cell cycle acceleration (Ferrandiz, 2009; Bretones, 2011; Garcia-Sanz, 2014; Garcia-Gutierrez, 2019)

b) Translational research in oncohemathology: roles of MYC oncogene and p27 in chronic lymphocytic leukemia (Caraballo et al., 2014) and in chronic myeloid leukemia (Albajar, 2011; Gomez-Casares,2013; García-Alegría, 2016)

c) Currently, his research interests focus on the roles of MYC network genes MXD1 (Lafita-Navarro, 2016) and MNT, the most relevant members MXD superfamily of transcriptional regulators (Lafita-Navarro, 2016; Lafita-Navarro 2019) and finding new interactions of MNT that may explain some of its biological functions (Liaño-Pons, 2020; Cancers 2020).

Teaching Activity and Transference

J. León teaches in the courses of “Biochemistry” and “Molecular Biology” of Medicine Degree and a course on “Molecular Bases of Cell Proliferation” in the Master of Molecular Biology and Biomedicine. He has co-authored a textbook, “Manual de Genética Molecular” (Ed. Sintesis, 1994). He has filed three patents

Administrative and evaluation activities

J. León has served as Head of the Department of Molecular Biology, Director of the IBBTEC and Vice-chancellor for Research. He has served in 7 projects evaluation panels of Plan Estatal I+D, and of international agencies (UK, Australia,

 javier.leon@unican.es

 Pabellón de Gobierno. Avda. de los Castros, 54. 39005 Santander

Catedrático de Universidad

Doctor en Farmacia

 CONTROL TRANSCRIPCIONAL DEL CÁNCER Y REGULACIÓN DE LA DIVISIÓN CELULAR

 INST. DE BIOMEDICINA Y BIOTECNOLOGÍA DE CANTABRIA

Áreas de especialidad: BIOQUIMICA Y BIOLOGIA MOLECULAR

ORCID: 0000-0001-5803-0112

Scopus Author: 7202142731

 Publicaciones  Proyectos  Tesis dirigidas  Patentes y tecnologías  Otras actividades
21 resultados 
       

A novel role of MNT as a negative regulator of REL and the NF-?B pathway

Artículo de Revista

Oncogenesis. 2021 Jan 8;10(1):5

 Autoría: JUDIT LIAÑO PONS, MARIA DEL CARMEN LAFITA NAVARRO, LORENA GARCIA GAIPO, CARLOTA COLOMER, JAVIER RODRÍGUEZ, ALEX VON KRIESGHEIM, PETER J HURLIN, FABIANA OURIQUE DA SILVA, MARIA DOLORES DELGADO VILLAR, ANNA BIGAS, ML ESPINOSA, JAVIER LEON SERRANO

 2021

The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells

Artículo de Revista

J Biol Chem . 2020 Feb 14;295(7):2001-2017. doi: 10.1074/jbc.RA119.010389.

 Autoría: MARIA DEL CARMEN LAFITA NAVARRO, JUDIT LIAÑO PONS, ANDREA QUINTANILLA CAVIA, IGNACIO VARELA EGOCHEAGA, ROSA FERNANDA BLANCO FERNANDEZ, FABIANA OURIQUE DA SILVA, GABRIEL BRETONES SANCHEZ, JULIA ARESTI, ESTER MOLINA HOYO, PATRICK CARROLL, PETER HURLIN, OCTAVIO A. ROMERO, MONTSE SÁNCHEZ-CÉSPEDES, ROBERT N. EISENMAN, MARIA DOLORES DELGADO VILLAR, JAVIER LEON SERRANO

 09/01/2020

MYC Oncogene Contributions to Release of Cell Cycle Brakes

Artículo de Revista

Genes (Basel). 2019 Mar 22;10(3). pii: E244

 Autoría: LUCIA GARCIA GUTIERREZ, MARIA DOLORES DELGADO VILLAR, JAVIER LEON SERRANO

 2019

Suppression of BCL6 Function by HDAC Inhibitor Mediated Acetylation and Chromatin Modification Enhances BET Inhibitor Effects in B-cell Lymphoma Cells

Artículo de Revista

Sci Rep, 9 (1), 16495 2019 Nov 11

 Autoría: MARIA GABRIELA CORTIGUERA RUIZ, LORENA GARCIA GAIPO, SIMON D. WAGNER, JAVIER LEON SERRANO, MARIA ANA BATLLE LOPEZ, MARIA DOLORES DELGADO VILLAR

 2019

Myc Stimulates Cell Cycle Progression Through the Activation of Cdk1 and Phosphorylation of p27

Artículo de Revista

Sci Rep , 9 (1), 18693

 Autoría: LUCIA GARCIA GUTIERREZ, GABRIEL BRETONES SANCHEZ, ESTER MOLINA HOYO, IGNACIO MARIA ARECHAGA ITURREGUI, CATHERINE SYMONDS, JUAN C. ACOSTA, ROSA FERNANDA BLANCO FERNANDEZ, ADRIÁN FERNÁNDEZ, LETICIA ALONSO, PIOTR SICINSKI, MARIANO BARBACID, DAVID SANTAMARÍA, JAVIER LEON SERRANO

 2019

The MYC antagonist MNT beyond MAX interaction

Comunicación a Congreso

ESMO Open 2018;3(Suppl 2):A157

 Autoría: MARIA DEL CARMEN LAFITA NAVARRO, JUDIT LIAÑO PONS, IGNACIO VARELA EGOCHEAGA, ROSA FERNANDA BLANCO FERNANDEZ, J. ARESTI, P. CARROLL, P.J. HURLIN, R.N. EISENMAN, MARIA DOLORES DELGADO VILLAR, JAVIER LEON SERRANO

 2018

ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA

Artículo de Revista

Oncogene. 2017 Mar 23;36(12):1733-1744

 Autoría: ANA TALAMILLO CANCELO, LARA GRANDE GONZALEZ, PATRICIA RUIZ ONTAÑÓN, CARLOS JOSE VELASQUEZ RODRIGUEZ, PILAR MOLLINEDO, SILVIA TORICES DEL VAL, PILAR SÁNCHEZ GÓMEZ, ÁNGELA AZNAR, AZUCENA ESPARIS OGANDO, CARLOS LÓPEZ LÓPEZ, MARIA DEL CARMEN LAFITA NAVARRO, MARIA TERESA BERCIANO BLANCO, JUAN ANTONIO MONTERO SIMON, ALFONSO VAZQUEZ BARQUERO, VÍCTOR SEGURA, NURIA T. VILLAGRA, ATANASIO PANDIELLA, MIGUEL ANGEL LAFARGA COSCOJUELA, JAVIER LEON SERRANO, JOSÉ A. MARTÍNEZ CLIMENT, VICTORIA SANZ MORENO, JOSE LUIS FERNANDEZ LUNA

 23/03/2017

The expression of MNT, a MYC antagonist, is autoregulated at the mRNA and protein level

Comunicación a Congreso

European Journal of Cancer, Vol. 61, Suppl. 1 (2016) S21-S22

 Autoría: MARIA DEL CARMEN LAFITA NAVARRO, JUDIT LIAÑO PONS, FABIANA OURIQUE DA SILVA, J. ARESTI, P.J. HURLIN, JAVIER LEON SERRANO

 2016

Myc-dependent cell cycle progression through the activation of CDK1 and phosphorylation of p27

Comunicación a Congreso

European Journal of Cancer, Vol. 61, Suppl. 1 (2016) S78

 Autoría: LUCIA GARCIA GUTIERREZ, GABRIEL BRETONES SANCHEZ, IGNACIO MARIA ARECHAGA ITURREGUI, D. SANTAMARÍA, M. BARBACID, JAVIER LEON SERRANO

 2016

CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia

Artículo de Revista

Oncotarget. 2016 Aug 19

 Autoría: BORJA GUERRA, PATRICIA MARTÍN RODRÍGUEZ, JUAN CARLOS DÍAZ CHICO, GRANT MCNAUGHTON-SMITH, SANDRA JIMÉNEZ ALONSO, IDAIRA HUESO FALCÓN, JUAN CARLOS MONTERO, RAQUEL BLANCO LANG, JAVIER LEON SERRANO, GERMÁN RODRÍGUEZ GONZÁLEZ, ANA ESTÉVEZ BRAUN, ATANASIO PANDIELLA, BONIFACIO NICOLÁS DÍAZ CHICO, LEANDRO FERNÁNDEZ PÉREZ

 2016

NUMB inactivation confers resistance to imatinib in chronic myeloid leukemia cells

Artículo de Revista

Cancer Lett. 2016 May 28;375(1):92-9

 Autoría: EVA GARCIA ALEGRIA, MARIA DEL CARMEN LAFITA NAVARRO, R. AGUADO, LUCIA GARCIA GUTIERREZ, KYLE SARNATARO, C. RUIZ HERGUIDO, F. MARTÍN, ANNA BIGAS, M. CANELLES, JAVIER LEON SERRANO

 2016

MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis

Artículo de Revista

Oncotarget. 2016 Aug 31

 Autoría: MARIA DEL CARMEN LAFITA NAVARRO, ROSA FERNANDA BLANCO FERNANDEZ, JORGE MATA GARRIDO, JUDIT LIAÑO PONS, OLGA TAPIA MARTINEZ, LUCIA GARCIA GUTIERREZ, EVA GARCIA ALEGRIA, MARIA TERESA BERCIANO BLANCO, MIGUEL ANGEL LAFARGA COSCOJUELA, JAVIER LEON SERRANO

 2016

El inhibidor de histonas deacetilasa romidepsina induce diferenciación en linfomas de origen centrogerminal a través de la regulación de BCL6

Comunicación a Congreso

Haematologica Oct. 2016 Vol.101 s4: 205-206

 Autoría: MARIA ANA BATLLE LOPEZ, MARIA GABRIELA CORTIGUERA RUIZ, LORENA GARCIA GAIPO, INSUNZA ANDRÉS, MARIA DE LAS MERCEDES COLORADO ARAUJO, JAVIER LEON SERRANO, MARIA DOLORES DELGADO VILLAR

 01/10/2016

Myc and cell cycle control

Artículo de Revista

BIOCHIMICA ET BIOPHYSICA ACTA-Gene Regulatory Mechanisms 2015. 1849: 506-516

 Autoría: GABRIEL BRETONES SANCHEZ, MARIA DOLORES DELGADO VILLAR, JAVIER LEON SERRANO

 2015

CD3e recruits Numb to promote TCR degradation

Artículo de Revista

Int Immunol. 2016 Mar;28(3):127-37

 Autoría: NADIA MARTÍN BLANCO, DANIEL JIMÉNEZ TEJA, GABRIEL BRETONES SANCHEZ, ALDO BORROTO, MICHAEL CARABALLO, ISABELLA SCREPANTI, JAVIER LEON SERRANO, BALBINO ALARCÓN, MATILDE CANELLES

 2015

MYC as therapeutic target in leukemia and lymphoma

Artículo de Revista

Blood and Lymphatic Cancer: Targets and Therapy 2015:5 75–91

 Autoría: MARIA GABRIELA CORTIGUERA RUIZ, MARIA ANA BATLLE LOPEZ, MARTA ALBAJAR MOLERA, MARIA DOLORES DELGADO VILLAR, JAVIER LEON SERRANO

 2015

A novel mutation in ADAMTS13 of a child with Upshaw-Schulman Syndrome

Artículo de Revista

Thromb Haemost. 2014 Nov;112(5):1065-8

 Autoría: A PÉREZ RODRÍGUEZ, MARIA ANA BATLLE LOPEZ, ROSA FERNANDA BLANCO FERNANDEZ, IGNACIO VARELA EGOCHEAGA, JAVIER LEON SERRANO, MARIA DOLORES DELGADO VILLAR, ESTHER LOURÉS, ÁNGELA RODRÍGUEZ TRILLO, ARÁNZAZU GARCÍA RIVERO, JOANA COSTA PINTO, JAVIER BATLLE, MARÍA FERNANDA LÓPEZ FERNÁNDEZ

 01/11/2014

High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle

Artículo de Revista

Oncotarget. 2014 Jul 15;5(13):4694-708

 Autoría: JUAN MANUEL CARABALLO OTERO, JUAN CARLOS ACOSTA COBACHO, MIGUEL ANGEL CORTES VAZQUEZ, MARTA ALBAJAR MOLERA, MARIA TERESA GOMEZ CASARES, MARIA ANA BATLLE LOPEZ, MARIA ANGELES CUADRADO DEL BARRIO, ARANTZA ONAINDIA PEREZ, GABRIEL BRETONES SANCHEZ, FRANCISCO JAVIER LLORCA DIAZ, MIGUEL ANGEL PIRIS PINILLA, DOLORES COLOMER PUJOL, JAVIER LEON SERRANO

 15/07/2014

Sin3b interacts with Myc and decreases Myc levels

Artículo de Revista

J Biol Chem. 2014 Aug 8;289(32):22221-36

 Autoría: PABLO GARCIA SANZ, ANDREA QUINTANILLA CAVIA, MARIA DEL CARMEN LAFITA NAVARRO, GEMA MORENO BUENO, LUCIA GARCIA GUTIERREZ, VEDRANA TABOR, IGNACIO VARELA EGOCHEAGA, YUZURU SHIIO, LARS-GUNNAR LARSSON, FRANCISCO PORTILLO, JAVIER LEON SERRANO

 08/08/2014

Myc mediates the phosphorylation and degradation of p27 through activation of Cyclin A/CDK1

Comunicación a Congreso

European Journal of Cancer Volume 50, Supplement 5, July 2014 Pages S72

 Autoría: LUCIA GARCIA GUTIERREZ, GABRIEL BRETONES SANCHEZ, IGNACIO MARIA ARECHAGA ITURREGUI, DAVID SANTAMARÍA, MARIANO BARBACID, JAVIER LEON SERRANO

 01/07/2014

21 resultados 
       

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