Inicio de sesión

Contact

Dr. Jesús Sainz
Phone: (+34) 942 201577 / Fax : (+34) 942 266399

Email: sainzjv@unican.es

Mailing address: IBBTEC. C/ Albert Einstein 22, PCTCAN, 39011 Santander

Genomics and Bioinformatics

JesusSainz2.jpg

Principal Investigator

Dr. Jesús Sainz, Staff Scientist (CSIC) 


Research line

Population genetics of complex diseases

 

Financing

Ministerio de Educación 2011-2014
The Children 's Hospital of Philadelphia - Research Institute 2012-2014

 

Relevant Publications (last 10 years)

  • Identification of candidate genes for Parkinson's disease through blood transcriptome analysis in LRRK2-G2019S carriers, idiopathic cases, and controls. Infante J, Prieto C, Sierra M, Sánchez-Juan P, González-Aramburu I, Sánchez-Quintana C, Berciano J, Combarros O, Sainz J.
    Neurobiol Aging
    . 2015 Feb;36(2):1105-9. doi: 10.1016/j.neurobiolaging.2014.10.039. Epub 2014 Nov 5. [pubmed]

  • Activation of nuclear receptor NR5A2 increases Glut4 expression and glucose metabolism in muscle cells. Bolado-Carrancio A, Riancho JA, Sainz J, Rodríguez-Rey JC.
    Biochem Biophys Res Commun
    . 2014 Apr 4;446(2):614-9. doi: 10.1016/j.bbrc.2014.03.010. Epub 2014 Mar 12. [pubmed]
  • Neuroanatomical Differences between First-Episode Psychosis Patients with and without Neurocognitive Deficit: A 3-Year Longitudinal Study. Ayesa-Arriola R, Roiz-Santiáñez R, Pérez-Iglesias R, Ferro A, Sainz J, Crespo-Facorro B.
    Front Psychiatry
    . 2013 Oct 17;4:134. doi: 10.3389/fpsyt.2013.00134. [pubmed]
  • Inflammatory and immune response genes have significantly altered expression in schizophrenia. Sainz J, Mata I, Barrera J, Perez-Iglesias R, Varela I, Arranz MJ, Rodriguez MC, Crespo-Facorro B.
    Mol Psychiatry
    . 2013 Oct;18(10):1056-7. doi: 10.1038/mp.2012.165. Epub 2012 Nov 20. [pubmed]
  • Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis. Delgado-Calle J, Fernández AF, Sainz J, Zarrabeitia MT, Sañudo C, García-Renedo R, Pérez-Núñez MI, García-Ibarbia C, Fraga MF, Riancho JA.[pubmed]
    Arthritis Rheum
    . 2013 Jan;65(1):197-205. doi: 10.1002/art.37753. [pubmed]
  • Zarrabeitia MT, Valero C, Martín-Escudero JC, Olmos JM, Bolado-Carrancio A, de Sande-Nacarino EL, Rodríguez-Rey JC, Sainz J, Riancho JA. Association study of sirtuin 1 polymorphisms with bone mineral density and body mass index. Arch Med Res. 2012 Jul;43(5):363-8. Epub 2012 Jul 21.
  • Sainz J (2012). A Methodology to Identify and Prioritize Gene Candidates for Human Disease. Front. Gene. 3:133. doi: 10.3389/fgene.2012.00133.
  • Riancho JA, Liu Y, Sainz J, García-Pérez MA, Olmos JM, Bolado-Carrancio A, Valero C, Pérez-López J, Cano A, Yang T, Sañudo C, Deng HW, Rodríguez-Rey JC. Nuclear receptor NR5A2 and bone: gene expression and association with bone mineral density. Eur J Endocrinol. 2012 Jan;166(1):69-75.
  • Sainz J, Mata I, Barrera J, Perez-Iglesias R, Varela I, Arranz MJ, Rodriguez MC, Crespo-Facorro B. Inflammatory and immune response genes have significantly altered expression in schizophrenia. Mol Psychiatry. 2012 Nov 20. [Epub ahead of print]
  • Deardorff MA, Sainz J, Grant SF (2011). Another tool in the genome-wide association study arsenal: population-based detection of somatic gene conversion. BMC Med. 3;9:13. Sanchez-Juan P, Bishop MT, Aulchenko YS, Brandel JP, Rivadeneira F, Struchalin M, Lambert JC, Amouyel P, Combarros O, Sainz J, Carracedo A, Uitterlinden AG, Hofman A, Zerr I, Kretzschmar HA, Laplanche JL, Knight RS, Will RG, van Duijn CM. Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk. Neurobiol Aging. 2011 Nov 30.
    Riancho JA, Vázquez L, García-Pérez MA, Sainz J, Olmos JM, Hernández JL, Pérez-López J, Amado JA, Zarrabeitia MT, Cano A, Rodríguez-Rey JC. Association of ACACB polymorphisms with obesity and diabetes. Mol Genet Metab. 2011 Dec;104(4):670-6.
  • J Sainz, P Rovensky, S Gudjonsson, G Thorleifsson, K Stefansson, JR Gulcher. (2006) Segmental duplication density decrease with distance to human-mouse breaks of synteny European Journal of Human Genetics 14:216-21.
  • A Helgadottir, A Manolescu, A Helgason, G Thorleifsson, U Thorsteinsdottir, D Gudbjartsson. S Grant, J Sainz, SJ O'Brien, SE Matthiasson, AI Levey, JL Abramson, M Reilly, V Vaccarino, M Wolfe, V Gudnason, AA Quyyumi, EJ Topol, DJ Rader, G Thorgeirsson, JR Gulcher, H Hakonarson, A Kong, K StefanssoN (2006) A variant of the gene encoding leukotriene A4 hydrolase confers ethnic specific risk of myocardial infarction. Nature Genetics  38:68-74.
  • S F.A. Grant, G Thorleifsson, I Reynisdottir, R Benediktsson, A Manolescu, J Sainz, A Helgason, H Stefansson, V Emilsson, A Helgadottir, U Styrkarsdottir, G. B Walters, E Palsdottir, T Jonsdottir, T Gudmundsdottir, A Gylfason, J Saemundsdottir, M P. Reilly, D J. Rader, Y Bagger, C Christiansen, V Gudnason, G Sigurdsson, U Thorsteinsdottir, J R. Gulcher, A Kong, K Stefansson (2006) Variant of the transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nature Genetics  38:320-3.
  • Amundadottir LT, Sulem P, Gudmundsson J, Helgason A, Baker A, Agnarsson BA, Sigurdsson A, Benediktsdottir KR, Cazier JB, Sainz J, Jakobsdottir M, Kostic J, Magnusdottir DN, Ghosh S, Agnarsson K, Birgisdottir B, Le Roux L, Olafsdottir A, Blondal T, Andresdottir M, Gretarsdottir OS, Bergthorsson JT, Gudbjartsson D, Gylfason A, Thorleifsson G, Manolescu A, Kristjansson K, Geirsson G, Isaksson H, Douglas J, Johansson JE, Balter K, Wiklund F, Montie JE, Yu X, Suarez BK, Ober C, Cooney KA, Gronberg H, Catalona WJ, Einarsson GV, Barkardottir RB, Gulcher JR, Kong A, Thorsteinsdottir U, Stefansson K (2006) A common variant associated with prostate cancer in European and African populations. Nature Genetics 38:652-8. 
  • H Stefansson, A Helgason, G Thorleifsson, V Steinthorsdottir, G Masson, J Barnard, A Baker, A Jonasdottir, A Ingason, VG Gudnadottir, N Desnica, A Hicks, A Gylfason, DF Gudbjartsson, GM Jonsdottir, J Sainz, K Agnarsson, B Birgisdottir, S Ghosh, A Olafsdottir, JB Cazier, K Kristjansson, ML Frigge, TE Thorgeirsson, JR Gulcher, A Kong, K Stefansson (2005). A common inversion under selection in Europeans. Nature Genetics. 37:129-37.
  • A Helgadottir, A Manolescu, G Thorleifsson, S Gretarsdottir, H Jonsdottir, U Thorsteinsdottir, NJ Samani, G Gudmundsson, SF Grant, G Thorgeirsson, S Sveinbjornsdottir, EM Valdimarsson, SE Matthiasson, H Johannsson, O Gudmundsdottir, ME Gurney , J Sainz, M Thorhallsdottir, M Andresdottir, ML Frigge, EJ Topol, A Kong, V Gudnason, H Hakonarson, JR Gulcher, K Stefansson (2004). The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nature Genetics. 36:233-9.
  • A Jonasdottir, T Thorlacius, R Fossdal, K Benediktsson, J Benedikz, HH Jonsson, J Sainz, H Einarsdottir, S Sigurdardottir, G Kristjansdottir, S Sawcer, A Compston, K Stefansson, J Gulcher (2003 ) A whole genome association study in Icelandic multiple sclerosis patients with 4804 markers. Journal of Neuroimmunology. 143:88-92. 
  • S Gretarsdottir, S Sveinbjornsdottir, HH Jonsson, F Jakobsson, E Einarsdottir, U Agnarsson, D Shkolny, G Einarsson, HM Gudjonsdottir, Valdimarsson EM, OB Einarsson,  G Thorgeirsson, R Hadzic, S Jonsdottir, ST Reynisdottir, SM Bjarnadottir, T Gudmundsdottir, GJ Gudlaugsdottir, R Gill, K Lindpaintner, J Sainz, HH Hannesson, GT Sigurdsson, ML Frigge, A Kong, V Gudnason, K Stefansson, JR Gulcher (2002). Localization of a susceptibility gene for common forms of stroke to 5q12. American Journal of Human Genetics 70:593-603
  • A Kong, D Gudbjartsson, J Sainz, G Jonsdottir, S Gudjonsson, B Richardsson, S Sigurdardottir, B Hallbeck, G Masson, A Shlien, S Palsson, ML Frigge, TE Thorgeirsson, JR Gulcher, Kstefansson (2002). A High Resolution Recombination Map of the Human Genome. Nature Genetics 31: 241-7.
  • H Stefansson, E Sigurdsson, V Steinthorsdottir, S Bjornsdottir, T Sigmundsson, S Ghosh, J Brynjolfsson, S Gunnarsdottir, O Ivarsson, TT Chou, O Hjaltason, B Birgisdottir, H Jonsson, VG Gudnadottir, E Gudmundsdottir, A Bjornsson, B Ingvarsson, A Ingason, S Sigfusson, H Hardardottir, RP Harvey, D Lai, M Zhou, D Brunner, V Mutel, G Acuňa, G Lemke, J Sainz, G Johannesson, T Andresson, D Gudbjartsson, A Manolescu, ML Frigge, ME Gurney, A Kong, JR Gulcher, H Petursson, and K Stefansson (2002). Neuregulin 1 and Susceptibility to Schizophrenia. American Journal of Human Genetics 71:877-892
  • A Hicks, H Peturson, T Jonsson, H Stefansson, J Sainz, M L. Frigge, A Kong, JR. Gulcher, K Stefansson (2002). A Susceptibility Gene  for Late-onset Idiopatic Parkinson Disease Mapped on Chromosome 1. Annals of Neurology 52:549-555.
  • G Gudmundsson, SE Matthiasson, H Arason, H Johannsson, F Runarsson, H Bjarnason, K Helgadottir, S Thorisdottir, G Ingadottir, K Lindpaintner, J Sainz, V Gudnason, ML Frigge, A Kong, JR Gulcher, K Stefansson. (2002). Localization of a gene for peripheral arterial occlusive disease to chromosome 1p31. American Journal of Human Genetics 70:586-92.