Inglés (Estados Unidos)

Alberto Sánchez Díaz (IP)

IBBTEC. Albert Einstein, 22; 39011 Santander
a.sanchezdiaz@unican.es
942206799
Mechanisms and Regulation of Cell Division
Principal Investigator; Associate Professor
Cancer
Department of Cell & Molecular Signalling

After completing his degree in Biology at the University of Salamanca (Spain), he has always focused his research on studying the eukaryotic cell cycle. He did his PhD with Dr. Sergio Moreno working on the regulation of G1 phase in fission yeast at the University of Salamanca too. He then stayed as a postdoctoral fellow with Dr. Karim Labib at the Cancer Research UK Manchester Institute in Manchester (UK) where he worked for almost ten years. In the first half of his time in the lab, he focused on identifying novel cell cycle factors and subsequently he worked on the molecular mechanisms and regulation of chromosome replication. In the second half, he studied the mechanisms and regulation of cell division. He joined the Institute of Biomedicine and Biotechnology of Cantabria and the Department of Molecular Biology in 2011 as a principal investigator where he is following his interest on how cells divide at the end of the cell cycle. In addition, he teaches in the Medical School at the University of Cantabria.

Mechanisms and Regulation of Cell Division

Research lines

Studying the molecular mechanisms and regulation of eukaryotic cell division.

Funding

Estudio de la función molecular del complejo Tor 1 en la división celular eucariota. Agencia Estatal de Investigación, PID2019-106745GB-I00.
Estudio del mecanismo molecular y la regulación de la citoquinesis en células eucariotas. Universidad de Cantabria. 2018-2019
Estudio y aprovechamiento de los mecanismos y regulación de la división celular en Saccharomyces cerevisiae. Ministerio de Economía y Competitividad. BFU2014-58081-P. 2015-2018
Mecanismo y Regulación de la Citoquinesis en la Levadura Saccharomyces cerevisiae. Cantabria Campus Internacional. 2011-2013
Mecanismo y Regulación de la Citoquinesis en la Levadura Saccharomyces cerevisiae. Ministerio de Economía y Competitividad BFU2011-23193. 2012-2014

TOR Complex 1: Orchestrating Nutrient Signaling and Cell Cycle Progression

Foltman M, Sanchez-Diaz A.

Int J Mol Sci. 2023 Oct 30;24(21):15745.

TOR complex 1 negatively regulates NDR kinase Cbk1 to control cell separation in budding yeast

Foltman M, Mendez I, Bech-Serra JJ, de la Torre C, Brace JL, Weiss EL, Lucas M, Queralt E, Sanchez-Diaz A.

PLoS Biol. 2023 Aug 30;21(8):e3002263.

PP2A-Cdc55 phosphatase regulates actomyosin ring contraction and septum formation during cytokinesis

Yolanda Moyano-Rodríguez, David Vaquero, Odena Vilalta-Castany, Magdalena Foltman, Alberto Sanchez-Diaz & Ethel Queralt

Cell. Mol. Life Sci. 79, 165 (2022)

Cell polarity protein Spa2 coordinates Chs2 incorporation at the division site in budding yeast

Foltman M, Filali-Mouncef Y, Crespo D, Sanchez-Diaz A.

PLoS Genet. 2018 Mar 30;14(3):e1007299. doi: 10.1371/journal.pgen.1007299.

Studying the Role of the Mitotic Exit Network in Cytokinesis

Foltman M., Sanchez-Diaz A.

Methods Mol Biol. 1505: 245-262 (2017).

Ingression Progression Complexes Control Extracellular Matrix Remodelling during Cytokinesis in Budding Yeast.

Foltman M, Molist I, Arcones I, Sacristan C, Filali-Mouncef Y, Roncero C, Sanchez-Diaz A.

PLoS Genet. 2016 Feb 18;12(2):e1005864. doi: 10.1371/journal.pgen.1005864. Erratum in: PLoS Genet. 2016 Apr;12(4):e1005988. PMID: 26891268; PMCID: PMC4758748.

Chitin synthesis and fungal cell morphogenesis

Roncero C., Sanchez-Diaz A. and Valdivieso M.-H.

The Mycota (Volumen III), 167-190

Synchronization of the budding yeast Saccharomyces cerevisiae.

Foltman M., Molist I., Sanchez-Diaz A.

Methods Mol Biol. 2016; 1369:279-91.

Studying protein-protein interactions in budding yeast using co-immunoprecipitation.

Foltman M., Sanchez-Diaz A.

Methods Mol Biol. 2016; 1369:239-56.

Hof1 and Rvs167 have redundant roles in actomyosin ring function during cytokinesis in budding yeast.

Nkosi P., Targosz B., Labib K., and Sanchez-Diaz, A.

Plos One 8 (2): e57846 (2013).

Inn1 and Cyk3 regulate the catalytic domain of chitin synthase during cytokinesis in budding yeasts.

Devrekanli, A., Foltman, M., Roncero, C., Sanchez-Diaz, A. and Labib K.

The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth.

Sanchez-Diaz, A., Nkosi, P., Murray, S. and Labib, K.

EMBO J., 31, 3620-3634 (2012).

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation.

Van Deursen F, Sengupta S, De Piccoli G, Sanchez-Diaz A., Labib K.

Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast.

Sanchez-Diaz, A., Marchesi, V., Murray, S., Jones, R., Pereira, G., Edmondson, R., Allen, T. and Labib K.

Nat Cell Biol. 10, 395-406 (2008).

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks.

Gambus A, Jones RC, Sanchez-Diaz A., Kanemaki M, van Deursen F, Edmondson R and Labib K.

Nat Cell Biol. 8, 358-66 (2006).

Rapid depletion of budding yeast proteins by fusion to a heat-inducible degron.

Sanchez-Diaz, A., Kanemaki, M., Marchesi, V. and Labib, K

Sci. STKE 2004, pl8 (2004).

Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo.

Kanemaki, M., Sanchez-Diaz, A., Gambus, A. and Labib, K.

Nature 423,720-4 (2003).

HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex.

Sanchez-Diaz, A., Blanco, M., Jones, N. and Moreno, S.

Current Genetics 40, 110-8 (2001).

APC(ste9/srw1) promotes degradation of mitotic cyclins in G1 and is inhibited by cdc2 phosphorylation.

Blanco, M., Sanchez-Diaz, A., de Prada, J.M. and Moreno, S.

EMBO J. 19, 3945-55 (2000).

The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast.

Sanchez-Diaz, A., Arellano, M., Gonzalez, I. and Moreno, S.

J Cell Sci. 111, 843-51 (1998).

A critical analysis of total sialic acid and sialoglycoconjugate contents of bovine milk-based infant formulas.

Sanchez-Diaz, A., Ruano, M.J., Lorente F. and Hueso P.

J Pediatr Gastroenterol Nutr. 24, 405-10 (1997).

Magdalena Foltman

IBBTEC

Instituto de Biomedicina y Biotecnología de Cantabria.
PCTCAN - Cl. Albert Einstein, 22
39011 Santander

Alberto Sánchez Díaz (IP)

Mechanisms and Regulation of Cell Division

Research lines

Funding

TOR Complex 1: Orchestrating Nutrient Signaling and Cell Cycle Progression

TOR complex 1 negatively regulates NDR kinase Cbk1 to control cell separation in budding yeast

PP2A-Cdc55 phosphatase regulates actomyosin ring contraction and septum formation during cytokinesis

Cell polarity protein Spa2 coordinates Chs2 incorporation at the division site in budding yeast

Studying the Role of the Mitotic Exit Network in Cytokinesis

Ingression Progression Complexes Control Extracellular Matrix Remodelling during Cytokinesis in Budding Yeast.

Chitin synthesis and fungal cell morphogenesis

Synchronization of the budding yeast Saccharomyces cerevisiae.

Studying protein-protein interactions in budding yeast using co-immunoprecipitation.

Hof1 and Rvs167 have redundant roles in actomyosin ring function during cytokinesis in budding yeast.

Inn1 and Cyk3 regulate the catalytic domain of chitin synthase during cytokinesis in budding yeasts.

The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth.

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation.

Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast.

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks.

Rapid depletion of budding yeast proteins by fusion to a heat-inducible degron.

Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo.

HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex.

APC(ste9/srw1) promotes degradation of mitotic cyclins in G1 and is inhibited by cdc2 phosphorylation.

The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast.

A critical analysis of total sialic acid and sialoglycoconjugate contents of bovine milk-based infant formulas.

Magdalena Foltman

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Alberto Sánchez Díaz (IP)

​Mechanisms and Regulation of Cell Division

Research lines

Funding

TOR Complex 1: Orchestrating Nutrient Signaling and Cell Cycle Progression

TOR complex 1 negatively regulates NDR kinase Cbk1 to control cell separation in budding yeast

PP2A-Cdc55 phosphatase regulates actomyosin ring contraction and septum formation during cytokinesis

Cell polarity protein Spa2 coordinates Chs2 incorporation at the division site in budding yeast​

Studying the Role of the Mitotic Exit Network in Cytokinesis

Ingression Progression Complexes Control Extracellular Matrix Remodelling during Cytokinesis in Budding Yeast.

Chitin synthesis and fungal cell morphogenesis

Synchronization of the budding yeast Saccharomyces cerevisiae.

Studying protein-protein interactions in budding yeast using co-immunoprecipitation.

Hof1 and Rvs167 have redundant roles in actomyosin ring function during cytokinesis in budding yeast.

Inn1 and Cyk3 regulate the catalytic domain of chitin synthase during cytokinesis in budding yeasts.

The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth.

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation.

Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast.

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks.

Rapid depletion of budding yeast proteins by fusion to a heat-inducible degron.

Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo.

HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex.

APC(ste9/srw1) promotes degradation of mitotic cyclins in G1 and is inhibited by cdc2 phosphorylation.

The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast.

A critical analysis of total sialic acid and sialoglycoconjugate contents of bovine milk-based infant formulas.

Magdalena Foltman

Sobre nosotros

Eventos

Contacto

Login

About us

Events

Contact

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IBBTEC

Mechanisms and Regulation of Cell Division

Cell polarity protein Spa2 coordinates Chs2 incorporation at the division site in budding yeast