Alberto Sánchez Díaz (IP)

  • IBBTEC. Albert Einstein, 22; 39011 Santander
  • a.sanchezdiaz@unican.es
  • 942206799
  • Mechanisms and Regulation of Cell Division
  • Principal Investigator; Associate Professor
  • Cancer
  • Department of Cell & Molecular Signalling

After completing his degree in Biology at the University of Salamanca (Spain), he has always focused his research on studying the eukaryotic cell cycle. He did his PhD with Dr. Sergio Moreno working on the regulation of G1 phase in fission yeast at the University of Salamanca too. He then stayed as a postdoctoral fellow with Dr. Karim Labib at the Cancer Research UK Manchester Institute in Manchester (UK) where he worked for almost ten years. In the first half of his time in the lab, he focused on identifying novel cell cycle factors and subsequently he worked on the molecular mechanisms and regulation of chromosome replication. In the second half, he studied the mechanisms and regulation of cell division. He joined the Institute of Biomedicine and Biotechnology of Cantabria and the Department of Molecular Biology in 2011 as a principal investigator where he is following his interest on how cells divide at the end of the cell cycle. In addition, he teaches in the Medical School at the University of Cantabria.

​Mechanisms and Regulation of Cell Division


Research lines

Studying the molecular mechanisms and regulation of eukaryotic cell division.

Funding

    • Universidad de Cantabria y Consejería de Universidades, Investigación, Medio Ambiente y Política Social del Gobierno de Cantabria
    • Estudio del mecanismo molecular y la regulación de la citoquinesis en células eucariotas. Universidad de Cantabria. 2018-2019
    • Estudio y aprovechamiento de los mecanismos y regulación de la división celular en Saccharomyces cerevisiae. Ministerio de Economía y Competitividad. BFU2014-58081-P. 2015-2018
    • Mecanismo y Regulación de la Citoquinesis en la Levadura Saccharomyces cerevisiae. Cantabria Campus Internacional. 2011-2013
    • Mecanismo y Regulación de la Citoquinesis en la Levadura Saccharomyces cerevisiae. Ministerio de Economía y Competitividad BFU2011-23193. 2012-2014


Cell polarity protein Spa2 coordinates Chs2 incorporation at the division site in budding yeast​

Cell polarity protein Spa2 coordinates Chs2 incorporation at the division site in budding yeast​

Foltman M, Filali-Mouncef Y, Crespo D, Sanchez-Diaz A.

PLoS Genet. 2018 Mar 30;14(3):e1007299. doi: 10.1371/journal.pgen.1007299.

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Studying the Role of the Mitotic Exit Network in Cytokinesis

Foltman M., Sanchez-Diaz A.

​ Methods Mol Biol. 1505: 245-262 (2017).

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Ingression Progression Complexes Control Extracellular Matrix Remodelling during Cytokinesis in Budding Yeast.

Foltman M, Molist I, Arcones I, Sacristan C, Filali-Mouncef Y, Roncero C, Sanchez-Diaz A.

​PLoS Genet. 2016 Feb 18;12(2):e1005864. doi: 10.1371/journal.pgen.1005864. Erratum in: PLoS Genet. 2016 Apr;12(4):e1005988. PMID: 26891268; PMCID: PMC4758748.​

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Chitin synthesis and fungal cell morphogenesis

Roncero C., Sanchez-Diaz A. and Valdivieso M.-H.

​The Mycota (Volumen III), 167-190

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Synchronization of the budding yeast Saccharomyces cerevisiae.

Foltman M., Molist I., Sanchez-Diaz A.

Methods Mol Biol. 2016; 1369:279-91.

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Studying protein-protein interactions in budding yeast using co-immunoprecipitation.

Foltman M., Sanchez-Diaz A.

​Methods Mol Biol. 2016; 1369:239-56.

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Hof1 and Rvs167 have redundant roles in actomyosin ring function during cytokinesis in budding yeast.

Nkosi P., Targosz B., Labib K., and Sanchez-Diaz, A.

​Plos One 8 (2): e57846 (2013).

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Inn1 and Cyk3 regulate the catalytic domain of chitin synthase during cytokinesis in budding yeasts.

Devrekanli, A., Foltman, M., Roncero, C., Sanchez-Diaz, A. and Labib K.

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The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth.

Sanchez-Diaz, A., Nkosi, P., Murray, S. and Labib, K.

​EMBO J., 31, 3620-3634 (2012). 

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Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation.

Van Deursen F, Sengupta S, De Piccoli G, Sanchez-Diaz A., Labib K.

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Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast.

Sanchez-Diaz, A., Marchesi, V., Murray, S., Jones, R., Pereira, G., Edmondson, R., Allen, T. and Labib K.

​Nat Cell Biol. 10, 395-406 (2008). 

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GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks.

Gambus A, Jones RC, Sanchez-Diaz A., Kanemaki M, van Deursen F, Edmondson R and Labib K.

​Nat Cell Biol. 8, 358-66 (2006).

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Rapid depletion of budding yeast proteins by fusion to a heat-inducible degron.

Sanchez-Diaz, A., Kanemaki, M., Marchesi, V. and Labib, K

​Sci. STKE 2004, pl8 (2004).

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Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo.

Kanemaki, M., Sanchez-Diaz, A., Gambus, A. and Labib, K.

​Nature 423,720-4 (2003).

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HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex.

Sanchez-Diaz, A., Blanco, M., Jones, N. and Moreno, S.

​Current Genetics 40, 110-8 (2001).

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APC(ste9/srw1) promotes degradation of mitotic cyclins in G1 and is inhibited by cdc2 phosphorylation.

Blanco, M., Sanchez-Diaz, A., de Prada, J.M. and Moreno, S.

​EMBO J. 19, 3945-55 (2000).

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The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast.

Sanchez-Diaz, A., Arellano, M., Gonzalez, I. and Moreno, S.

​J Cell Sci. 111, 843-51 (1998).

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A critical analysis of total sialic acid and sialoglycoconjugate contents of bovine milk-based infant formulas.

Sanchez-Diaz, A., Ruano, M.J., Lorente F. and Hueso P.

​J Pediatr Gastroenterol Nutr. 24, 405-10 (1997).​

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Magdalena Foltman

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