Álvaro Rada Iglesias (IP)

  • IBBTEC. C/ Albert Einstein 22, PCTCAN, 39011 Santander
  • alvaro.rada@unican.es
  • (+34) 942 203932
  • Transcriptional Regulation in Development and Congenital Disease
  • Principal Investigator; STAR2 Investigator
  • Developmental Biology
  • Department of Cell & Molecular Signalling

Alvaro Rada Iglesias received his M.Sc. in Biology by the University of Leon in 2001, being recognized as the best academic curriculum of that year. Then, he obtained his PhD in 2007 at Uppsala University (Sweden), where he worked in the laboratory of Prof. Claes Wadelius. After a short post-doctoral work in the Linnaeaus Centre for Bioinformatics (Uppsala University, Sweden) under the supervision of Prof. Jan Komorowski, he obtained an EMBO long-term fellowship to continue his postdoctoral career in the laboratory of Prof. Joanna Wysocka at Stanford University (USA), where he stayed between 2009-2013. In 2013, he was recruited by the University of Cologne as a Junior Research Group Leader at the Centre for Molecular Medicine Cologne, where he successfully started his independent research group. This was recognized with an EMBO Young Investigator award (EMBO YIP) in 2017. In July 2018 he was recruited as a Principal Investigator by the University of Cantabria to direct his research group at the Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC).

​Transcriptional regulation in development and congenital disease



Research lines

The major interest of our laboratory is to uncover the main genetic and epigenetic factors that allow the deployment of specific gene expression profiles as vertebrate developmental programs unroll. Our goal is to provide a deep mechanistic understanding of the non-coding genomic space that is dynamically and specifically used during mammalian embryogenesis, which is fundamental to reveal the molecular basis of human congenital diseases. More specifically, by functionally and mechanistically characterizing developmental enhancers, my laboratory aims at:

    • Uncovering transcriptional regulatory principles orchestrating mammalian embryogenesis.
    • Elucidating the genetic and epigenetic basis of human congenital diseases.

Funding

    • "Transcriptional Regulation during vertebrate Embryonic Patterning: from genomics to mechanism" – STAR2 Programme (Universidad de Cantabria; Banco Santander) - 2018/2023 – IP: Alvaro Rada Iglesias
    • "Embo Young Investigator Program (YIP)" – EMBO – 2018/2020 – IP: Alvaro Rada Iglesias
    • "Mechanistic characterization of poised enhancer function during the induction of major anterior neural regulatory loci" - German Research Foundation (DFG) - 2017/2020 – IP: Alvaro Rada Iglesias
    • "Identification and characterization of major stem cell regulators within the epidermis" - German Research Foundation (DFG) – 2017/2021 – IP: Alvaro Rada Iglesias
    • "A novel etiological mechanism for Branchio-Oculo-Facial Syndrome (BOFS) with implications for the current understanding of human neurocristopathies" - Else Kroner Fresenius Foundation - 2017/2019 - IP: Alvaro Rada Iglesias
    • "Functional and mechanistic characterization of Foxd3 during mouse peri-implantation transitions" – German Research Foundation (DFG) - 2016/2019 – IP: Alvaro Rada Iglesias
    • "A systems biology approach to characterize non-coding genetic variants associated with human disease" – University of Cologne Excellence Program – 2014/2017 - IP: Alvaro Rada Iglesias
    • "Bioinformatic and molecular characterization of non-coding genetic variants associated with craniofacial abnormalities" - Fritz Thyssen Foundation – 2014/2015 - IP: Alvaro Rada Iglesias
    • "Molecular mechanisms and functional relevance of poised developmental enhancers during embryonic stem cell differentiation" - German Research Foundation (DFG) – 2013/2016 – IP: Alvaro Rada Iglesias

Enhancer-associated H3K4 methylation safeguards in vitro germline competence

Bleckwehl T, Crispatzu G, Schaaf K, Respuela P, Bartusel M, Benson L, Clark SJ, Dorighi KM, Barral A, Laugsch M, van IJcken WFJ, Manzanares M, Wysocka J, Reik W, Rada-Iglesias Á.

​Nat Commun. 2021 Oct 1;12(1):5771. doi: 10.1038/s41467-021-26065-6.

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The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo

Giuliano Crispatzu, Rizwan Rehimi, Tomas Pachano, Tore Bleckwehl, Sara Cruz-Molina, Cally Xiao, Esther Mahabir, Hisham Bazzi & Alvaro Rada-Iglesias

​Nat Commun. 2021 Jul 16;12(1):4344. 

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Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness

Tomas Pachano, Víctor Sánchez-Gaya, Thais Ealo, Maria Mariner-Faulí, Tore Bleckwehl, Helena G. Asenjo, Patricia Respuela, Sara Cruz-Molina, María Muñoz-San Martín, Endika Haro, Wilfred F. J. van IJcken, David Landeira & Alvaro Rada-Iglesias

​Nat Genet. 2021 Jul;53(7):1036-1049.

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The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13

The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13

Maria Félix Bastida, Rocío Pérez-Gómez, Anna Trofka, Jianjian Zhu, Alvaro Rada-Iglesias, Rushikesh Sheth, H. Scott Stadler, Susan Mackem and Marian Ros

​Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1090-1096.

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Transcriptional and epigenetic control of germline competence and specification

Transcriptional and epigenetic control of germline competence and specification

Bleckwehl T, Rada-Iglesias A.

 2019 Jun 21;61:1-8. doi: 10.1016/j.ceb.2019.05.006. [Epub ahead of print]

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Pathological ASXL1 Mutations and Protein Variants Impair Neural Crest Development

Pathological ASXL1 Mutations and Protein Variants Impair Neural Crest Development

Geerlof A, Rishko V, Rada-Iglesias A, Drukker M.

 2019 May 14;12(5):861-868. doi: 10.1016/j.stemcr.2019.03.006. Epub 2019 Apr 18.

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Modeling the Pathological Long-Range Regulatory Effects of Human Structural Variation with Patient-Specific hiPSCs

Modeling the Pathological Long-Range Regulatory Effects of Human Structural Variation with Patient-Specific hiPSCs

Laugsch M, Bartusel M, Rehimi R, Alirzayeva H, Karaolidou A, Crispatzu G, Zentis P, Nikolic M, Bleckwehl T, Kolovos P, van Ijcken WFJ, Šarić T, Koehler K, Frommolt P, Lachlan K, Baptista J, Rada-Iglesias A.

Cell Stem Cell. 2019 May 2;24(5):736-752.e12. doi: 10.1016/j.stem.2019.03.004. Epub 2019 Apr 11.

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Enhanced Stress Response in 5-HT1AR Overexpressing Mice: Altered HPA Function and Hippocampal Long-Term Potentiation.

Pilar-Cuéllar F, Vidal R, Díaz Á, Garro-Martínez E, Linge R, Castro E, Haberzettl R, Fink H, Bert B, Brosda J, Romero B, Crespo-Facorro B, Pazos Á.

​ACS Chem Neurosci. 2017 Nov 15;8(11):2393-2401. doi: 10.1021/acschemneuro.7b00156. Epub 2017 Aug 18.​

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