Alvaro Rada Iglesias received his M.Sc. in Biology by the University of Leon in 2001, being recognized as the best academic curriculum of that year. Then, he obtained his PhD in 2007 at Uppsala University (Sweden), where he worked in the laboratory of Prof. Claes Wadelius. After a short post-doctoral work in the Linnaeaus Centre for Bioinformatics (Uppsala University, Sweden) under the supervision of Prof. Jan Komorowski, he obtained an EMBO long-term fellowship to continue his postdoctoral career in the laboratory of Prof. Joanna Wysocka at Stanford University (USA), where he stayed between 2009-2013. In 2013, he was recruited by the University of Cologne as a Junior Research Group Leader at the Centre for Molecular Medicine Cologne, where he successfully started his independent research group. This was recognized with an EMBO Young Investigator award (EMBO YIP) in 2017. In July 2018 he was recruited as a Principal Investigator by the University of Cantabria to direct his research group at the Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC).
The major interest of our laboratory is to uncover the main genetic and epigenetic factors that allow the deployment of specific gene expression profiles as vertebrate developmental programs unroll. Our goal is to provide a deep mechanistic understanding of the non-coding genomic space that is dynamically and specifically used during mammalian embryogenesis, which is fundamental to reveal the molecular basis of human congenital diseases. More specifically, by functionally and mechanistically characterizing developmental enhancers, my laboratory aims at:
Bleckwehl T, Crispatzu G, Schaaf K, Respuela P, Bartusel M, Benson L, Clark SJ, Dorighi KM, Barral A, Laugsch M, van IJcken WFJ, Manzanares M, Wysocka J, Reik W, Rada-Iglesias Á.
Nat Commun. 2021 Oct 1;12(1):5771. doi: 10.1038/s41467-021-26065-6.
Giuliano Crispatzu, Rizwan Rehimi, Tomas Pachano, Tore Bleckwehl, Sara Cruz-Molina, Cally Xiao, Esther Mahabir, Hisham Bazzi & Alvaro Rada-Iglesias
Nat Commun. 2021 Jul 16;12(1):4344.
Tomas Pachano, Víctor Sánchez-Gaya, Thais Ealo, Maria Mariner-Faulí, Tore Bleckwehl, Helena G. Asenjo, Patricia Respuela, Sara Cruz-Molina, María Muñoz-San Martín, Endika Haro, Wilfred F. J. van IJcken, David Landeira & Alvaro Rada-Iglesias
Nat Genet. 2021 Jul;53(7):1036-1049.
Maria Félix Bastida, Rocío Pérez-Gómez, Anna Trofka, Jianjian Zhu, Alvaro Rada-Iglesias, Rushikesh Sheth, H. Scott Stadler, Susan Mackem and Marian Ros
Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1090-1096.
Bleckwehl T, Rada-Iglesias A.
Curr Opin Cell Biol. 2019 Jun 21;61:1-8. doi: 10.1016/j.ceb.2019.05.006. [Epub ahead of print]
Geerlof A, Rishko V, Rada-Iglesias A, Drukker M.
Stem Cell Reports. 2019 May 14;12(5):861-868. doi: 10.1016/j.stemcr.2019.03.006. Epub 2019 Apr 18.
Laugsch M, Bartusel M, Rehimi R, Alirzayeva H, Karaolidou A, Crispatzu G, Zentis P, Nikolic M, Bleckwehl T, Kolovos P, van Ijcken WFJ, Šarić T, Koehler K, Frommolt P, Lachlan K, Baptista J, Rada-Iglesias A.
Cell Stem Cell. 2019 May 2;24(5):736-752.e12. doi: 10.1016/j.stem.2019.03.004. Epub 2019 Apr 11.
Pilar-Cuéllar F, Vidal R, Díaz Á, Garro-Martínez E, Linge R, Castro E, Haberzettl R, Fink H, Bert B, Brosda J, Romero B, Crespo-Facorro B, Pazos Á.
ACS Chem Neurosci. 2017 Nov 15;8(11):2393-2401. doi: 10.1021/acschemneuro.7b00156. Epub 2017 Aug 18.
Instituto de Biomedicina y Biotecnología de Cantabria.
PCTCAN - Cl. Albert Einstein, 22