Diane has obtained her Bachelor's degree in "Cell Biology, Molecular Genetics and Physiology" at the University of Rennes 1 (France) in 2017.
As a member of the International Section, she naturally did her first internship abroad at The Institute of Infection, Immunity and Inflammation (University of Glasgow, Scotland).
Then in 2019, she graduated her Master's degree in "Cellular and Molecular Biology" in the University of Rennes 1 (France). The Major of her diploma was "Dynamic of the cell communication, Drugs development and Therapeutic Innovation".
During her Master's degree, Diane did two Internship focused on Cell Death Pathways:
The first one was on Necroptosis in the Team of Prof. James Murphy at the Walter and Eliza Hall Institute (Melbourne, Australia). The second one was on Apoptosis in the Cancer Cell Death Team at the Cancer Research Center of Lyon (CRCL Lyon, France).
Now, as PhD student supervised by Dr.Fernando Calvo, she is investigating the crosstalk between cancer-associated fibroblasts and endothelial cells.
-Petrie et al (2019), ''Viral MLKL homologs subvert Necroptotic Cell Death by sequestering cellular RIPK3'', Cell Report, Vol 28, Issue 13, pages 3309-3319
Cytoskeletal regulators of cancer dissemination. Our team is interested in understanding why and how cancer cells spread through the body. Using state-of-the-art in vitro approaches and pre-clinical models, we study the reciprocal interactions between invading/metastatic cells and their microenvironment, and the molecular rearrangements that promote efficient metastatic behaviours in cancer cells, with a particular emphasis in the modulation of the cytoskeleton.
Mechanisms of stromal reprogramming in cancer. We investigate the environmental cues (chemical or physical) and signals from malignant cells that lead to the emergence of tumour-promoting phenotypes in otherwise normal cells of the tumour microenvironment, with a particular focus in cancer-associated fibroblasts (CAF). Using molecular and bioinformatics tools, we examine patterns of gene expression and signal activation in cancer stroma. We then investigate the effect of reciprocal interactions between cancer cells and normal cells in these patterns, their relevance in tumoural processes and strategies to perturb them to deter tumour progression.
Characterisation of the role of CAF heterogeneity in tumour progression. We have developed in vitro and in vivo systems to investigate CAF behaviour, their contribution to the hallmarks of cancer (e.g. cancer cell growth, invasion, angiogenesis, immune suppression), and the molecular mechanisms controlling them. However, there is molecular and functional heterogeneity within the CAF population, which has a major impact in tumour evolution and therapeutic response. Our team aims at examining this diversity and its contribution to metastatic dissemination and resistance.
Instituto de Biomedicina y Biotecnología de Cantabria.
PCTCAN - Cl. Albert Einstein, 22