Fernando got a BSc in Biochemistry at the Universidad del Pais Vasco (2001). Following a year at AstraZeneca (Manchester, UK), he joined the group of Piero Crespo at CSIC/Universidad de Cantabria (Santander, Spain), where he obtained a PhD studying Ras GTPases in 2008. He then carried out post-doctoral work in London (Erik Sahai) where he studied cancer metastasis and the tumour microenvironment. In 2013 he set up his own group at The Institute of Cancer Research (London, UK). In 2018 he returned to Santander where he leads the Tumour Microenvironment Team at the IBBTEC. Fernando's group uses a wide range of techniques from conventional cell and molecular biology, through in vivo models and analysis of clinical material, to study the role of the tumour microenvironment in cancer progression, dissemination and response to therapy.
Dr Calvo has authored more than 30 peer-reviewed publications in SCI journals, including Nature Cell Biology, Nature Communications, Journal of Cell Biology y Journal of National Cancer Institute. Throughout his career he has been regularly funded by national and international grants, including Worldwide Cancer Research Grant, CRUK Multidiciplinary Award. He has mentored 1 doctoral and 1 master theses and he has been honoured by different national and international research awards. He acts as a reviewer for numerous scientific journals and granting agencies. He has been invited as a speaker to more than 40 meetings, workshops and seminar series in national and international universities and scientific institutions.
Cytoskeletal regulators of cancer dissemination. Our team is interested in understanding why and how cancer cells spread through the body. Using state-of-the-art in vitro approaches and pre-clinical models, we study the reciprocal interactions between invading/metastatic cells and their microenvironment, and the molecular rearrangements that promote efficient metastatic behaviours in cancer cells, with a particular emphasis in the modulation of the cytoskeleton.
Mechanisms of stromal reprogramming in cancer. We investigate the environmental cues (chemical or physical) and signals from malignant cells that lead to the emergence of tumour-promoting phenotypes in otherwise normal cells of the tumour microenvironment, with a particular focus in cancer-associated fibroblasts (CAF). Using molecular and bioinformatics tools, we examine patterns of gene expression and signal activation in cancer stroma. We then investigate the effect of reciprocal interactions between cancer cells and normal cells in these patterns, their relevance in tumoural processes and strategies to perturb them to deter tumour progression.
Characterisation of the role of CAF heterogeneity in tumour progression. We have developed in vitro and in vivo systems to investigate CAF behaviour, their contribution to the hallmarks of cancer (e.g. cancer cell growth, invasion, angiogenesis, immune suppression), and the molecular mechanisms controlling them. However, there is molecular and functional heterogeneity within the CAF population, which has a major impact in tumour evolution and therapeutic response. Our team aims at examining this diversity and its contribution to metastatic dissemination and resistance.
Aaron J. Farrugia, Javier Rodríguez, Jose L. Orgaz, María Lucas, Victoria Sanz-Moreno, Fernando Calvo
J Cell Biol (2020) 219 (9): e201912159. https://doi.org/10.1083/jcb.201912159. Epub 2020 Aug 14
Woolston A, Khan K, Spain G, Barber L, Griffiths B, Gonzalez Exposito R, Patil Y, Punta M, Mansukhani S, Davies M, Furness A, Sclafani F, Peckitt C, Kouvelakis K, Ranftl R, Begum R, Rana I, Thomas J, Bryant A, Quezada S, Wotherspoon A, Khan N, Lise S, Fot
Cancer Cell 36, 35-50.
Ylenia Perone, Aaron J. Farrugia, Alba Rodríguez Meira, Balázs Győrffy, Charlotte Ion, Andrea Uggetti, Antonios Chronopoulos, Pasquale Marrazzo, Monica Faronato, Sami Shousha, Claire Davies, Jennifer H. Steel, Naina Patel, Armando del Rio Hernandez, Charl
Nature Communicationsvolume 10, Article number: 2115 (2019)
Santra T, Herrero A, Rodriguez J, von Kriegsheim A, Iglesias-Martinez LF, Schwarzl T, Higgins D, Aye TT, Heck AJR, Calvo F, Agudo-Ibáñez L, Crespo P, Matallanas D, Kolch W.
Cell Rep. 2019 Mar 12;26(11):3100-3115.e7. doi: 10.1016/j.celrep.2019.02.038.
Ferrari N, Ranftl R, Chicherova I, Slaven ND, Moeendarbary E, Farrugia AJ, Lam M, Semiannikova M, Westergaard MCW, Tchou J, Magnani L, Calvo F*
Nature Communications 2019, Jan 10; 10:130
Álvarez-Teijeiro S, García-Inclán S, Villaronga MA, Casado P, Hermida-Prado F, Granda-Díaz R, Rodrigo JP, Calvo F, del Rio-Ibisate N, Gandarillas A, Morís F, Hermsen M, Cutillas P, García-Pedrero JM
Cancers 10(9), 334.
Lam M and Calvo F*
Cytoskeleton. Aug 9. doi: 10.1002/cm.21485.
Herrero A, Reis-Cardoso M, Jimenez-Gomez I, Doherty C, Agudo Ibanez L, Pinto A, Calvo F, Kolch W, Crespo P, Matallanas DG
Small GTPases Nov 26:1-13.
Ranftl R and Calvo F*
Methods in Molecular Biology 1612:199-212.
Farrugia AJ and Calvo F*
Small GTPases Jan 2;8(1):49-57.
Biochemical Society Transactions. Dec 02,44 (6) 1709-1716.
Calvo F*, Ranftl R, Hooper S, Farrugia AJ, Moeendarbary E, Bruckbauer A, Batista F, Charras G and Sahai E*
Avgustinova A, Iravani M, Robertson D, Fearns A, Gao Q, Klingbeil P, Hanby AM, Speirs V, Sahai E, Calvo F, and Isacke CM
Nature CommunicationsJan 18; 7:10305.
Del Pozo-Martin Y, Park D, Ramachandran A, Ombrato L, Calvo F, Chakravarty P, Spencer-Dene B, Derzsi S, Hill CS, Sahai E and Malanchi I
Cell Reports 13(11):2456-69.
Herraiz C, Calvo F, Pandya P, Cantelli G, Rodriguez-Hernandez I, Orgaz JL, Kang N, Chu T, Sahai E, Sanz-Moreno V
Journal of National Cancer Institute. 108(1): djv289.
Suresh S, Valdez Y, Xu A, O’Byrne A, Calvo F, Lei V and Conway EM.
BMC Cancer 14(1):113.
Calvo F, Ege N, Grande-Garcia A, Hooper S, Jenkins RP, Chaudhry S, Harrington K, Williamson P, Moeendarbary E, Charras G and Sahai E.
Nature Cell Biology 15: 637-646.
Calvo F and Sahai S.
Current Opinions in Cell Biology. 23:1–9..
Crespo P, Calvo F, Sanz-Moreno V. Bioarchitecture. 2011 Jul;1(4):200-204.
Calvo F., Sanz-Moreno V, Agudo-Ibáñez L., Wallberg F., Sahai E., Marshall C.J., and Crespo P. Nat. Cell Biol. 13, 819-826. (2011). (Seleccionado por The Faculty of 1000).
Arozarena I., Calvo F., Agudo-Ibañez L. and Crespo P. Genes & Cancer. 182-194. (2011).
Calvo F, Sanz-Moreno V, Agudo-Ibáñez L, Wallberg F, Sahai E, Marshall CJ and Crespo P.
Nature Cell Biology13(7):819-26.
Rodríguez J., Calvo F., González J.M., Casar B., Andrés V. and Crespo P. J. Cell Biol. 191, 967-979. (2010). (Editorial en el mismo número; Editorial en Science Sig. 3, ec371 2010; Seleccionado por The Faculty of 1000).
Calvo F., Agudo-Ibáñez L., and Crespo P. Bioessays. 32, 412-421. (2010).
Instituto de Biomedicina y Biotecnología de Cantabria.
PCTCAN - Cl. Albert Einstein, 22