Francisco Calderón is a graduate in Chemistry from the University of the Basque Country. He carried out a 1-year Socrates-Erasmus project at Utrecht University (Netherlands), working on the modeling of phospholipid membrane solubilization. He completed his PhD in Analytical Chemistry at the University of Oviedo, under the supervision of Alfredo Sanz-Medel and Jorge Ruiz, obtaining the cum laude distinction and the Extraordinary Doctoral Award. His research focused on the development of analytical strategies based on elemental mass spectrometry and miniaturized chromatography for the absolute quantification of proteins, mainly protein toxins from snake venoms, in collaboration with Juan J. Calvete (IBV-CSIC). 

In 2019, he joined the University of Pau (France) as a postdoctoral researcher in the group of Ryszard Lobinski, to develop new analytical strategies based on high-resolution mass spectrometry and multidimensional chromatography for the characterization of metal-complexing microbial metabolites. In 2022, he returned to the University of Oviedo through a Margarita Salas Joven postdoctoral fellowship, focusing on the quantitative study of proteins and phosphoproteins in complex biological samples.

His work has driven the development of new instrumental configurations in ICP-MS to achieve universal quantitative strategies in proteomic speciation analysis, addressing challenges such as carbon-induced ionization effects and nebulization and transport effects in large biomolecules. He has also contributed to the development of analytical strategies focused on the study and characterization of nanomaterials and their interaction with biomolecules or biological media.

In 2026, he joined the Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC) and the University of Cantabria (UC) as a Ramón y Cajal Researcher. His research focuses on the development and application of advanced analytical techniques, as well as the design of new synthetic materials with enzymatic activity, for the study of biomolecules in biological systems.