Juan María García Lobo (IP)

  • IBBTEC. Albert Dinstein, 22; 39011 Santander
  • juan.garcialobo@unican.es
  • 942 201948
  • Molecular Biology of Brucella Pathogenicity
  • Principal Investigator
  • Microbiology & Genomics
  • Department of Microbiology & Genomics

Juan M García Lobo holds a PhD degree in Biological Science issued by the University of the Basque Country. After a postdoctoral formation in UCLA (Los Ángeles) and UMDNJ (Piscataway, New Jersey)  he was appointed as Microbiology  professor at the Medical School of the University of Cantabria. He is also a head of research group in the IBBTEC. His work was mainly focused in the mechanisms of mobility of antibiotic resistance genes in medically important bacteria and the pathogenicity of Brucella. Actually he is involved in the Preventive Conservation Altamira Cave, specifically in the assessment of biodeterioration risks.

​Molecular Biology of Brucella Pathogenicity


Research lines 

    •  Brucella virulence factors (and their regulation).
    •  Metagenomics and microbial ecology

Group history

Our research group holds a long record of activity in the field of Molecular Microbiology. Our previous work in mechanisms of recombination and mobility of antibiotic resistance genes in medically important bacteria was  followed by the analysis of molecular pathogenicity of Brucella giving significant contributions to new vaccines and epidemiological methods.  By adopting high throughput methods and new generation sequencing we broadened our studies in Brucella and starting moving to the field of metagenomics and ambiental microbiology.

Funding

Control y seguimiento del biodeterioro y de las condiciones ambientales del agua de infiltracion y de las emisiones de gas radón de la cueva de Altamira" Ref.: 2018CC100242. Ministerio de Cultura y Deprte. Subdirección General de Museos Estatales. Duración 15/10/2018-01/09/2020.

Polymorphisms in Brucella Carbonic anhydrase II mediate CO2 dependence and fitness in vivo.

García Lobo JM, Ortiz Y, González-Riancho C, Seoane A, Arellano-Reynoso B, and Sangari FJ.

​Frontiers in Microbiology, 2019 (BioRxiv doi: 10.1101/804740)

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Twitter as a Tool for Teaching and Communicating Microbiology: The #microMOOCSEM Initiative.

López-Goñi I, et al. Twitter as a Tool for Teaching and Communicating Microbiology: The #microMOOCSEM Initiative. J Microbiol Biol Educ. 2016 Dec 2;17(3):492-494. doi: 10.1128/jmbe.v17i3.1200

​J Microbiol Biol Educ. 2016 Dec 2;17(3):492-494. doi: 10.1128/jmbe.v17i3.1200​

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Survival of Brucella abortus aqpX Mutant in Fresh and Ripened Cheeses.

Santiago-Rodríguez Mdel R, Díaz-Aparicio E, Arellano-Reynoso B, García Lobo JM, Gimeno M, Palomares-Reséndiz EG, Hernández-Castro R.

​Foodborne Pathog Dis. 2015 Feb;12(2):170-5. doi: 10.1089/fpd.2014.1823. Epub 2014 Dec 31.

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An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.

Brownstein CA, Beggs AH et al. Genome Biol. 2014 Mar 25;15(3):R53. doi: 10.1186/gb-2014-15-3-r53.

[pubmed]

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PROGRAMA DE INVESTIGACIÓN PARA LA CONSERVACIÓN PREVENTIVA Y RÉGIMEN DE ACCESO DE LA CUEVA DE ALTAMIRA (2012-2014). Informe final

VV. AA.

​http://www.culturaydeporte.gob.es/mnaltamira/dam/jcr:23aff8fe-2c0c-474a-8db4-c34b644bcde9/conservacionpreventivaaltamira-informefinal-doc-investigacion.pdf

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The exploration of Brucella transcriptome: From the ORFeome to RNAseq (book).

García-Lobo JM Rodríguez MC,Seoane A, Sangari FJ, López-Goñi I. Lopez Goñi and O'Callaghan eds. Brucella. Molecular Microbiology and Genomics. pp 89-102. Caister Academic Press. Norfolk, UK, 2012.

[pubmed]

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Evaluation of the effects of erythritol on gene expression in Brucella abortus.

Rodríguez MC, Viadas C, Seoane A, Sangari FJ, López-Goñi I, García-Lobo JM. PLoS One. 2012;7(12):e50876. doi: 10.1371/journal.pone.0050876.

[pubmed]

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Differences in two-component signal transduction proteins among the genus Brucella: implications for host preference and pathogenesis.

Lavín JL, Binnewies TT, Pisabarro AG, Ussery DW, García-Lobo JM, Oguiza JA. Vet Microbiol. 2010 Aug 26;144(3-4):478-83. doi: 10.1016/j.vetmic.2010.01.007. Epub 2010 Jan 28.

[pubmed]

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A new family of enzymes catalyzing the first committed step of the methylerythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis in bacteria.

Sangari FJ, Pérez-Gil J, Carretero-Paulet L, García-Lobo JM, Rodríguez-Concepción M. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14081-6. doi: 10.1073/pnas.1001962107.

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Transcriptome analysis of the Brucella abortus BvrR/BvrS two-component regulatory system.

Viadas C, Rodríguez MC, Sangari FJ, Gorvel JP, García-Lobo JM, López-Goñi I. PLoS One. 2010 Apr 21;5(4):e10216. doi: 10.1371/journal.pone.0010216.

[pubmed]

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Brucella abortus ure2 region contains an acid-activated urea transporter and a nickel transport system.

Sangari FJ, Cayón AM, Seoane A, García-Lobo JM. BMC Microbiol. 2010 Apr 10;10:107. doi: 10.1186/1471-2180-10-107.

[pubmed]

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Candela González-Riancho Fernández

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Yelina Ortiz Pérez

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Félix Sangari García

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Asunción Seoane Seoane

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