Inglés (Estados Unidos)

Mª Pilar Garcillán Barcia (IP)

IBBTEC; Albert Einstein, 22; 39011 Santander - Cantabria
maria.garcillan@unican.es
942 206 796
Functional Plasmidomics
Principal Investigator
Microbiology & Genomics
Department of Microbiology & Genomics

Functional Plasmidomics

Research lines

Plasmids are genomes with a deep impact in microbial communities, a shared gene pool that allows bacteria to adapt to different environments. By using plasmid comparative genomics, we are identifying and studying key gene functions for cell-to-cell communication, as well as others linked to multirresistant bacteria outbreaks. Some of these functions are also harnessed to build synthetic gene circuits to perform distributed computation in bacterial populations.

Funding

Research projects: Ayuda nueva incorporación CSIC (Ref. 201820I143). PI: M. Pilar Garcillán-Barcia

A novel and diverse group of Candidatus Patescibacteria from bathypelagic Lake Baikal revealed through long-read metagenomics

Haro-Moreno JM, Cabello-Yeves PJ, Garcillán-Barcia MP, Zakharenko A, Zemskaya TI, Rodriguez-Valera F.

Environ Microbiome. 2023 Feb 23;18(1):12.

The Facts and Family Secrets of Plasmids That Replicate via the Rolling-Circle Mechanism

Garcillán-Barcia MP, Pluta R, Lorenzo-Díaz F, Bravo A, Espinosa M.

Microbiol Mol Biol Rev. 2021 Dec 8;86(1):e0022220.

Pathways for horizontal gene transfer in bacteria revealed by a global map of their plasmids

Santiago Redondo-Salvo, Raúl Fernández-López, Raúl Ruiz, Luis Vielva, María de Toro, Eduardo P C Rocha, M Pilar Garcillán-Barcia, Fernando de la Cruz

Nat Commun. 2020 Jul 17;11(1):3602. doi: 10.1038/s41467-020-17278-2.

ArdC, a ssDNA-binding protein with a metalloprotease domain, overpasses the recipient hsdRMS restriction system broadening conjugation host range

Lorena González-Montes, Irene Del Campo, M Pilar Garcillán-Barcia, Fernando de la Cruz, Gabriel Moncalián

PLoS Genet. 2020 Apr 29;16(4):e1008750. doi: 10.1371/journal.pgen.1008750. eCollection 2020 Apr.

Comparative genomics of the conjugation region of F-like plasmids: five shades of F.

Fernandez Lopez R, De Toro Hernando M, Moncalian G, Garcillán-Barcia MP and de la Cruz F

Fernandez Lopez R, De Toro Hernando M, Moncalian G, Garcillán-Barcia MP and de la Cruz F (2016) Comparative genomics of the conjugation region of F-like plasmids: five shades of F. Front Mol Biosci. doi: 10.3389/fmolb.2016.00071

Genomics of high molecular weight plasmids isolated from an on-farm biopurification system.

Martini MC, Wibberg D, Lozano M, Torres Tejerizo G, Albicoro FJ, Jaenicke S, van Elsas JD, Petroni A, Garcillán-Barcia MP, de la Cruz F, Schlüter A, Pühler A, Pistorio M, Lagares A, Del Papa MF. Sci Rep. 2016 Jun 20;6:28284. doi: 10.1038/srep28284.

[PubMed]

Degenerate primer MOB typing of multiresistant clinical isolates of E. coli uncovers new plasmid backbones.

Garcillán-Barcia MP, Ruiz Del Castillo B, Alvarado A, de la Cruz F, Martínez-Martínez L. Plasmid. 2015 Jan;77:17-27. doi: 10.1016/j.plasmid.2014.11.003.

[pubmed]

Plasmid Flux in Escherichia coli ST131 Sublineages, Analyzed by Plasmid Constellation Network (PLACNET), a New Method for Plasmid Reconstruction from Whole Genome Sequences.

Lanza VF, de Toro M, Garcillán-Barcia MP, Mora A, Blanco J, Coque TM, de la Cruz F. PLoS Genet. 2014 Dec 18;10(12):e1004766. doi: 10.1371/journal.pgen.1004766.

[pubmed]

Bringing them together: plasmid pMV158 rolling circle replication and conjugation under an evolutionary perspective.

Lorenzo-Díaz F, Fernández-López C, Garcillán-Barcia MP, Espinosa M. Plasmid. 2014 Jul;74:15-31. doi: 10.1016/j.plasmid.2014.05.004.

[pubmed]

Key components of the eight classes of type IV secretion systems involved in bacterial conjugation or protein secretion.

Guglielmini J, Néron B, Abby SS, Garcillán-Barcia MP, de la Cruz F, Rocha EP. Nucleic Acids Res. 2014;42(9):5715-27. doi: 10.1093/nar/gku194.

[pubmed]

Plasmid conjugation from proteobacteria as evidence for the origin of xenologous genes in cyanobacteria.

Encinas D, Garcillán-Barcia MP, Santos-Merino M, Delaye L, Moya A, de la Cruz F. J Bacteriol. 2014 Apr;196(8):1551-9. doi: 10.1128/JB.01464-13.

[pubmed]

Genomic analysis of the emergence and evolution of multidrug resistance during a Klebsiella pneumoniae outbreak including carbapenem and colistin resistance.

López-Camacho E, Gómez-Gil R, Tobes R, Manrique M, Lorenzo M, Galván B, Salvarelli E, Moatassim Y, Salanueva IJ, Pareja E, Codoñer FM, Alvarez-Tejado M, Garcillán-Barcia MP, De la Cruz F, Mingorance J. J Antimicrob Chemother. 2013 Oct 23.

[pubmed]

Ordering the bestiary of genetic elements transmissible by conjugation.

Garcillán-Barcia MP, de la Cruz F. Mob Genet Elements. 2013 Jan 1;3(1):e24263.

[pubmed]

A degenerate primer MOB typing (DPMT) method to classify gamma-proteobacterial plasmids in clinical and environmental settings.

Alvarado A, Garcillán-Barcia MP, de la Cruz F. PLoS One. 2012;7(7):e40438.

[pubmed]

Ana Cuevas Venero

Daniel García López

Antonio Mesa Galán

Arancha Peñil Celis

María Del Mar Quiñonero Coronel

Jesús Rodriguez Lozano

IBBTEC

Instituto de Biomedicina y Biotecnología de Cantabria.
PCTCAN - Cl. Albert Einstein, 22
39011 Santander

Mª Pilar Garcillán Barcia (IP)

Functional Plasmidomics

Research lines

Funding

A novel and diverse group of Candidatus Patescibacteria from bathypelagic Lake Baikal revealed through long-read metagenomics

The Facts and Family Secrets of Plasmids That Replicate via the Rolling-Circle Mechanism

Pathways for horizontal gene transfer in bacteria revealed by a global map of their plasmids

ArdC, a ssDNA-binding protein with a metalloprotease domain, overpasses the recipient hsdRMS restriction system broadening conjugation host range

Comparative genomics of the conjugation region of F-like plasmids: five shades of F.

Genomics of high molecular weight plasmids isolated from an on-farm biopurification system.

Degenerate primer MOB typing of multiresistant clinical isolates of E. coli uncovers new plasmid backbones.

Plasmid Flux in Escherichia coli ST131 Sublineages, Analyzed by Plasmid Constellation Network (PLACNET), a New Method for Plasmid Reconstruction from Whole Genome Sequences.

Bringing them together: plasmid pMV158 rolling circle replication and conjugation under an evolutionary perspective.

Key components of the eight classes of type IV secretion systems involved in bacterial conjugation or protein secretion.

Plasmid conjugation from proteobacteria as evidence for the origin of xenologous genes in cyanobacteria.

Genomic analysis of the emergence and evolution of multidrug resistance during a Klebsiella pneumoniae outbreak including carbapenem and colistin resistance.

Ordering the bestiary of genetic elements transmissible by conjugation.

A degenerate primer MOB typing (DPMT) method to classify gamma-proteobacterial plasmids in clinical and environmental settings.

Ana Cuevas Venero

Daniel García López

Antonio Mesa Galán

Arancha Peñil Celis

María Del Mar Quiñonero Coronel

Jesús Rodriguez Lozano

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IBBTEC

Mª Pilar Garcillán Barcia (IP)

​Functional Plasmidomics

Research lines

Funding

A novel and diverse group of Candidatus Patescibacteria from bathypelagic Lake Baikal revealed through long-read metagenomics

The Facts and Family Secrets of Plasmids That Replicate via the Rolling-Circle Mechanism

Pathways for horizontal gene transfer in bacteria revealed by a global map of their plasmids

ArdC, a ssDNA-binding protein with a metalloprotease domain, overpasses the recipient hsdRMS restriction system broadening conjugation host range

Comparative genomics of the conjugation region of F-like plasmids: five shades of F.

Genomics of high molecular weight plasmids isolated from an on-farm biopurification system.

Degenerate primer MOB typing of multiresistant clinical isolates of E. coli uncovers new plasmid backbones.

Plasmid Flux in Escherichia coli ST131 Sublineages, Analyzed by Plasmid Constellation Network (PLACNET), a New Method for Plasmid Reconstruction from Whole Genome Sequences.

Bringing them together: plasmid pMV158 rolling circle replication and conjugation under an evolutionary perspective.

Key components of the eight classes of type IV secretion systems involved in bacterial conjugation or protein secretion.

Plasmid conjugation from proteobacteria as evidence for the origin of xenologous genes in cyanobacteria.

Genomic analysis of the emergence and evolution of multidrug resistance during a Klebsiella pneumoniae outbreak including carbapenem and colistin resistance.

Ordering the bestiary of genetic elements transmissible by conjugation.

A degenerate primer MOB typing (DPMT) method to classify gamma-proteobacterial plasmids in clinical and environmental settings.

Ana Cuevas Venero

Daniel García López

Antonio Mesa Galán

Arancha Peñil Celis

María Del Mar Quiñonero Coronel

Jesús Rodriguez Lozano

Sobre nosotros

Eventos

Contacto

Login

About us

Events

Contact

Login

IBBTEC

Functional Plasmidomics