The epigenetic regulator CTCF modulates BCL6 in lymphoma. The epigenetic regulator CTCF modulates BCL6 in lymphoma. Batlle-López A, Cortiguera MG, Delgado MD. ONCOSCIENCE 2015. 2 (10): 783-784 (Editorial).2015-06-14T22:00:00Z<p style="text-align:justify;"><strong class="ms-rteThemeFontFace-1 ms-rteFontSize-2">​Abstract</strong></p><p style="text-align:justify;"><span class="ms-rteThemeFontFace-1 ms-rteFontSize-2" style="color:#000000;background-color:#ffffff;">Despite the improvements in the diagnosis and in the approaches to treatment, aggressive lymphomas are still an important cause of morbidity and mortality. There is, therefore, considerable interest in understanding the mechanisms involved in the process of lymphomagenesis. Germinal centers are dynamic structures within the lymph nodes containing highly proliferating B-cells that are undergoing mutations, in order to produce high affinity maturation antibodies, and for these reasons are predisposed to the formation of malignancies. Indeed, a number of mature lymphoid neoplasms are generated in these structures.</span><br></p><p><span class="ms-rteForeColor-2"><a href="">​[pubmed]</a></span></p>108