HOX13 proteins: the molecular switcher in Hoxd bimodal regulation.HOX13 proteins: the molecular switcher in Hoxd bimodal regulation.Ros, MA2016-05-14T22:00:00Z<p style="text-align:justify;">​<span class="ms-rteThemeForeColor-2-5 ms-rteThemeFontFace-1 ms-rteFontSize-2" style="font-weight:bold;">Abstract</span></p><div><p>The striking correlation between the genomic arrangement of Hox genes and their temporal and spatial pattern of expression during embryonic development has been a source of fascination since its discovery. This correspondence has been used as a privileged example in the investigation of the connection between genomic architecture and function. In this issue of Genes & Development, Beccari and colleagues (pp. 1172-1186) make a big step forward in understanding Hox gene regulation during limb development by showing the pivotal role of HOXA13 and HOXD13 proteins in the transition from a proximal to a distal type of Hoxd transcriptional regulation.<br></p></div><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/27222515"><span class="ms-rteThemeForeColor-5-0" style="">​Genes Dev. 2016 May 15;30(10):1135-7.</span></a><br></p>227