Drug Weaponry to Fight Against SARS-CoV-2Drug Weaponry to Fight Against SARS-CoV-2Cabezón E, Arechaga I.2020-08-24T22:00:00Z<h3>Abstract<br></h3><div> <br> </div><div>The current outbreak of SARS-CoV-2 virus has caused a large increase in mortality and morbidity associated with respiratory diseases. Huge efforts are currently ongoing to develop a vaccine against this virus. However, alternative approaches could be considered in the fight against this disease. Among other strategies, structural-based drug design could be an effective approach to generate specific molecules against SARS-CoV-2, thus reducing viral burden in infected patients. Here, in addition to this structural approach, we also revise several therapeutic strategies to fight against this viral threat. Furthermore, we report ACE-2 genetic polymorphic variants affecting residues involved in close contacts with SARS-CoV-2 that might be associated to different infection risks. These analyses could provide valuable information to predict the course of the disease.<br></div> <br><p><a href="https://www.frontiersin.org/articles/10.3389/fmolb.2020.00204/full">Front Mol Biosci. 2020 Aug 25;7:204.</a><br></p>414