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The RAS-ERK pathway: A route for couples.The RAS-ERK pathway: A route for couples.Santos E, Crespo P. 2018-10-29T23:00:00Z<p>Data accumulated over more than three decades demonstrate that the assembly of macrocomplexes, mainly of dimers, is widespread among the members of the different tiers that constitute the RAS-ERK pathway. In this issue of <em>Science Signaling</em>, Yuan et al. report that MEK1 homodimerization is necessary for signal transduction through the RAF-ERK pathway and that cancer-related MEK1 mutations confer enhanced dimerization and resistance to MEK inhibitors. These findings endorse interference with RAS-ERK pathway-component dimerization as a potential therapeutic strategy in cancer patients.​<br></p><p>​<span title="Science signaling">Sci Signal</span>. 2018 Oct 30;11(554). pii: eaav0917. doi: 10.1126/scisignal.aav0917.<br></p>304