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Tumors topple when ERKs uncouple.Tumors topple when ERKs uncouple.Herrero A, Crespo P. Mol Cell Oncol. 2015 Oct 29;3(2):e1091875. eCollection 2016 Mar. 2015-10-28T23:00:00Z<p style="text-align&#58;justify;"><span class="ms-rteThemeFontFace-1 ms-rteFontSize-2"><span class="ms-rteThemeForeColor-2-5 ms-rteThemeFontFace-1 ms-rteFontSize-2" style="font-weight&#58;bold;">Abstract</span><br></span></p><div style="color&#58;#000000;font-family&#58;arial, helvetica, clean, sans-serif;text-align&#58;justify;"><p style="margin-bottom&#58;0.5em;font-size&#58;1.04em;"><span class="ms-rteThemeFontFace-1 ms-rteFontSize-2">Current antitumor therapies targeting the RAS-ERK pathway have been mostly aimed at inhibiting the activity of the kinases that populate the route. A small-molecule inhibitor of ERK dimerization effectively prevents the progression of tumors harboring oncogenic RAS and BRAF, demonstrating that targeting regulatory protein-protein interactions can be a valid strategy for treating RAS-ERK pathway-driven neoplasia.</span><br></p></div><p>​<span style="color&#58;#474f51;font-family&#58;&quot;yanone kaffeesatz&quot;;font-size&#58;18px;background-color&#58;#ffffff;">[</span><a href="http&#58;//www.ncbi.nlm.nih.gov/pubmed/27308614" style="color&#58;#ed391b;margin&#58;0px;padding&#58;0px;border&#58;0px;font-stretch&#58;inherit;font-size&#58;18px;line-height&#58;inherit;font-family&#58;&quot;yanone kaffeesatz&quot;;vertical-align&#58;baseline;background-color&#58;#ffffff;">PubMed</a><span style="color&#58;#474f51;font-family&#58;&quot;yanone kaffeesatz&quot;;font-size&#58;18px;background-color&#58;#ffffff;">]</span><br></p>46
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