Researchers portal

FACULTAD DE MEDICINA

942 201953

Group website

Research lines

Papel miRNAs en diferenciación - Head: JOSE CARLOS RODRIGUEZ REY
Papel MOZ en formación de hueso - Head: FLOR MARIA PEREZ CAMPO
Silenciamiento Smurf1 en MSC - Head: JOSE CARLOS RODRIGUEZ REY

Equipment

Cell culture. Molecular Biology equipment (including fluorescence analysis)

Operating laboratories

Instalaciones del Departamento de Biología Molecular

Services

Aislamiento y cultivo decélulas madre mesenquimales reguladoras.
Aislamiento de células madre mesenquimales a partir de tejidos y crecimiento de las mismas en soportes biocompatibles.

Collaborating Entities

CONSEJERÍA DE EDUCACIÓN, FORMACIÓN PROFESIONAL Y UNIVERSIDADES
Fundación Española de Investigaciones Óseas y Metabolismo Mineral
FUNDACION INSTITUTO DE INVESTIGACION MARQUES DE VALDECILLA
GOBIERNO DE CANTABRIA
INSTITUTO DE SALUD CARLOS III
STEMVITAL S.L.

Members Publications Projects Supervised Theses Datasets

2 results

FLOR MARIA PEREZ CAMPO

Profesor Contratado Doctor

Publications
48
Projects
10
Thesis
1
Patents and technologies
1
Datasets
1

JOSE CARLOS RODRIGUEZ REY

Group manager

Catedrático de Universidad

Publications
42
Projects
10
Thesis
10
Patents and technologies
1

2 results

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Year of publication

65 results

1 of 3 Next Last

Engineering a pro-osteogenic secretome through the transient silencing of the gene encoding secreted frizzled related protein 1

Article

International journal of molecular sciences, 2023, 24(15), 12399

Authorship: DANIEL GARCÍA-SÁNCHEZ, ALBERTO GONZALEZ GONZALEZ, ITZÍAR ÁLVAREZ-IGLESIAS, ALFONSO BOLADO-CARRANCIO, MATILDE CERTO, MARIA ISABEL PEREZ NUÑEZ, JOSE ANTONIO RIANCHO MORAL, JOSE CARLOS RODRIGUEZ REY, JESÚS DELGADO-CALLE, FLOR MARIA PEREZ CAMPO, MÓNICA DEL DUJO GUTIÉRREZ

2023

Communication between bone marrow mesenchymal stem cells and multiple myeloma cells: impact on disease progression

Article

World Journal of Stem Cells, 2023, 15(5), 281-501

Authorship: DANIEL GARCIA SANCHEZ, ALBERTO GONZALEZ GONZALEZ, ANA ALFONSO FERNANDEZ, MÓNICA DEL DUJO-GUTIÉRREZ, FLOR MARIA PEREZ CAMPO

2023

Desarrollo de secretoma proosteogénico mediante el silenciamiento transitorio del gen que codifica secreted frizzled related protein 1 (Sfrp1)

Conference object

Revista de Osteoporosis y Metabolismo Mineral, 2023, 15(S1), 8

Authorship: DANIEL GARCÍA SÁNCHEZ, ALBERTO GONZALEZ GONZALEZ, ALFONSO BOLADO CARRANCIO, ITIZIAR ÁLVAREZ IGLESIAS, MÓNICA DEL DUJO GUTIÉRREZ, MATILDE CERTO, MARIA ISABEL PEREZ NUÑEZ, JOSE ANTONIO RIANCHO MORAL, JOSE CARLOS RODRIGUEZ REY, JESÚS DELGADO CALLE, FLOR MARIA PEREZ CAMPO

2023

Regenerative medicine applied to the treatment of musculoskeletal pathologies

Book part

Handbook of stem cell therapy

Authorship: ALBERTO GONZALEZ GONZALEZ, DANIEL GARCIA SANCHEZ, ANA ALFONSO-FERNÁNDEZ, KHAWAJA HUSNAIN HAIDER, JOSE CARLOS RODRIGUEZ REY, FLOR MARIA PEREZ CAMPO

2022

Cytotoxicity analysis of oxazine 4-perchlorate fluorescence nerve potential clinical biomarker for guided surgery

Article

Biomedical Optics Express, 2022, 13(1), 197-208

Authorship: SANDRA PAMPIN SUAREZ, JOSE LUIS ARCE DIEGO, OLGA TAPIA MARTINEZ, FLOR MARIA PEREZ CAMPO, JOSE CARLOS RODRIGUEZ REY, FELIX FANJUL VELEZ

01/01/2022

Coaxial synthesis of PEI-based nanocarriers of encapsulated RNA-therapeutics to specifically target muscle cells

Article

Biomolecules , 2022, 12(8),1012

Authorship: RAQUEL DE LA HOZ RUIZ, NAZELY DIBAN-IBRAHIM GOMEZ, MARIA TERESA BERCIANO BLANCO, CARLOS SAN EMETERIO LÓPEZ, ANA MARIA URTIAGA MENDIA, MIGUEL ANGEL LAFARGA COSCOJUELA, JOSE CARLOS RODRIGUEZ REY, OLGA TAPIA MARTINEZ

22/07/2022

Osteonecrosis of the femoral head: a multidisciplinary approach in diagnostic accuracy

Article

Diagnostics (Basel) . 2022 Jul 16;12(7):1731

Authorship: ADRIÁN CARDÍN-PEREDA, DANIEL GARCIA SANCHEZ, NURIA TERAN VILLAGRA, ANA ALFONSO-FERNÁNDEZ, MICHEL FAKKAS, CARLOS GARCÉS-ZARZALEJO, FLOR MARIA PEREZ CAMPO

2022

Nanoparticle-mediated selective Sfrp-1 silencing enhances bone density in osteoporotic mice

Article

J Nanobiotechnology . 2022 Oct 29;20(1):462

Authorship: PATRICIA GARCÍA-GARCÍA, RICARDO REYES, DANIEL GARCIA SANCHEZ, FLOR MARIA PEREZ CAMPO, JOSE CARLOS RODRIGUEZ REY, CARMEN ÉVORA, PATRICIA DÍAZ-RODRÍGUEZ, ARACELI DELGADO

2022

Desarrollo y aplicación de secretoma con efecto osteogénico procedente de células madre mesenquimales para el tratamiento de la osteoporosis

Conference object

Revista de Osteoporosis y Metabolismo Mineral 2022;14(3): 4-12

Authorship: ALBERTO GONZALEZ GONZALEZ, DANIEL GARCIA SANCHEZ, R. REYES, JOSE CARLOS RODRIGUEZ REY, FLOR MARIA PEREZ CAMPO

2022

Effective Osteogenic Priming of Mesenchymal Stem Cells through LNA-ASOs-Mediated Sfrp1 Gene Silencing

Article

Pharmaceutics, Volume 13, Issue 8, August 2021 Article number 1277,

Authorship: DANIEL GARCIA SANCHEZ, ALBERTO GONZALEZ GONZALEZ, PATRICIA GARCÍA GARCÍA, RICARDO REYES, MARIA ISABEL PEREZ NUÑEZ, JOSE ANTONIO RIANCHO MORAL, CARMEN ÉVORA, JOSE CARLOS RODRIGUEZ REY, FLOR MARIA PEREZ CAMPO

17/08/2021

Methylation of the sclerostin (sost) gene in serum free dna: a new bone biomarker?

Article

Genetic Testing and Molecular Biomarkers, 2021, 25(1), 42-47

Authorship: ÁLVARO DEL REAL BOLT, FLOR MARIA PEREZ CAMPO, MARIA ISABEL PEREZ NUÑEZ, MARIA CAROLINA SAÑUDO CAMPO, ANA SANTURTUN ZARRABEITIA, MARIA DEL CARMEN GARCIA IBARBIA, MARIA TERESA GARCIA UNZUETA, MARIO F. FRAGA, AGUSTÍN F. FERNÁNDEZ, MARIA DEL CARMEN VALERO DIAZ DE LAMADRID, MARIA ESTHER LAGUNA BERCERO, JOSE ANTONIO RIANCHO MORAL

01/01/2021

Comparison of technologies to synthesize polyethylenimine-citrate nanocomplexes as drug delivery vehicles for molecular targeting

Conference object

Proceedings of the 6th International Symposium on Green and Smart Technologies for a Sustainable Society: 9-10 diciembre 2021

Authorship: RAQUEL DE LA HOZ RUIZ, NAZELY DIBAN-IBRAHIM GOMEZ, ANA MARIA URTIAGA MENDIA, JOSE CARLOS RODRIGUEZ REY, OLGA TAPIA MARTINEZ

2021

Mislocalization of SMN from the I-band and M-band in human skeletal myofibers in spinal muscular atrophy associates with primary structural alterations of the sarcomere

Article

Cell and Tissue Research, 2020, 381(3), 461-478

Authorship: MARIA TERESA BERCIANO BLANCO, MARIA SOLEDAD CASTILLO IGLESIAS, JOSE FERNANDO VAL BERNAL, VANESA LAFARGA BERCIANO, JOSE CARLOS RODRIGUEZ REY, MIGUEL ANGEL LAFARGA COSCOJUELA, OLGA TAPIA MARTINEZ

16/06/2020

Nusinersen ameliorates motor function and prevents motoneuron Cajal body disassembly and abnormal poly(A) RNA distribution in a SMA mouse model

Article

Sci Rep . 2020 Jul 1;10(1):10738

Authorship: MARIA TERESA BERCIANO BLANCO, ALBA PUENTE BEDIA, ALMUDENA MEDINA MAMAMÉ, JOSE CARLOS RODRIGUEZ REY, JORDI CALDERÓ, MIGUEL ANGEL LAFARGA COSCOJUELA, OLGA TAPIA MARTINEZ

01/07/2020

Long noncoding RNAs as bone marrow stem cell regulators in osteoporosis

Article

DNA and Cell Biology, 2020, 39(9),1691-1699

Authorship: ÁLVARO DEL REAL BOLT, LAURA LÓPEZ-DELGADO, MARIA CAROLINA SAÑUDO CAMPO, MARIA DEL CARMEN GARCIA IBARBIA, MARIA ESTHER LAGUNA BERCERO, FLOR MARIA PEREZ CAMPO, GUILLERMO MENENDEZ SOLANA, ANA ALFONSO FERNANDEZ, MICHEL FAKKAS FERNANDEZ, BELEN MARIA GARCIA MONTESINOS PEREA, MARIA DEL CARMEN VALERO DIAZ DE LAMADRID, MARIA ISABEL PEREZ NUÑEZ, JOSE ANTONIO RIANCHO MORAL

01/09/2020

Estudio del efecto combinado de la Oxacina 4 Perclorato y la irradiación en la citotoxicidad de células U87

Conference object

CASEIB 2020: XXXVIII Congreso Anual de la Sociedad Española de Ingeniería Biomédica: Libro de actas

Authorship: SANDRA PAMPIN SUAREZ, FLOR MARIA PEREZ CAMPO, JOSE CARLOS RODRIGUEZ REY, JOSE LUIS ARCE DIEGO, FELIX FANJUL VELEZ

2020

Discovery of genes and proteins possibly regulating mean wool fibre diameter using cDNA microarray and proteomic approaches

Article

Sci Rep . 2020 May 7;10(1):7726.

Authorship: JINSHAN ZHAO, HUAIYUAN QIN, JINGJING XIN, NAN LIU, RONGWEI HAN, FLOR MARIA PEREZ CAMPO, HEGANG LI

2020

Construction of CRISPR Plasmids and Detection of Knockout Efficiency in Mammalian Cells through a Dual Luciferase Reporter System

Article

J Vis Exp . 2020 Dec 5;(166).

Authorship: HEGANG LI, HUAIYUAN QIN, NING ZHANG, JINSHAN ZHAO, JINGJING XIN, FLOR MARIA PEREZ CAMPO, HUAWEI LIU

2020

Mesenchymal stem cells secretome: the cornerstone of cell-free regenerative medicine

Article

World Journal of Stem Cells, 2020 12(12), 1529-1552

Authorship: ALBERTO GONZALEZ GONZALEZ, DANIEL GARCIA SANCHEZ, MONICA DOTTA, JOSE CARLOS RODRIGUEZ REY, FLOR MARIA PEREZ CAMPO

01/12/2020

Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells

Article

World Journal of Stem Cells, 2019, 11(10), 748-763

Authorship: DANIEL GARCIA-SANCHEZ, DARIO FERNANDEZ, JOSE CARLOS RODRIGUEZ REY, FLOR MARIA PEREZ CAMPO

2019

Smurf1 Silencing Using a LNA-ASOs/Lipid Nanoparticle System to Promote Bone Regeneration

Article

Stem Cells Transl Med , 8 (12), 1306-1317

Authorship: PATRICIA GARCÍA-GARCÍA, MARIO RUIZ, RICARDO REYES, ARACELI DELGADO, CARMEN ÉVORA, JOSE ANTONIO RIANCHO MORAL, JOSE CARLOS RODRIGUEZ REY, FLOR MARIA PEREZ CAMPO

2019

Reorganization of the nuclear compartments involved in transcription and RNA processing in myonuclei of type I spinal muscular atrophy

Article

Histochem Cell Biol, 152 (3), 227-237 Sep 2019

Authorship: MARIA SOLEDAD CASTILLO IGLESIAS, MARIA TERESA BERCIANO BLANCO, JOSEP ORIOL NARCIS MAJOS, JOSE FERNANDO VAL BERNAL, JOSE CARLOS RODRIGUEZ REY, OLGA TAPIA MARTINEZ, MIGUEL ANGEL LAFARGA COSCOJUELA

2019

Application of oligonucleotides to construct a conditional targeting vector for porcine IKBa

Article

Mol Med Rep. 2018 Jan;17(1):653-659

Authorship: HEGANG LI, XIAONA SONG, FENG YANG, HANXUN BAO, XIAOLONG LU, FLOR MARIA PEREZ CAMPO, JINSHAN ZHAO

01/01/2018

Is serum free DNA methylation a bone biomarker

Conference object

Rev Osteoporos Metab Miner 2018 10;3:48

Authorship: ÁLVARO DEL REAL BOLT, MARIA CAROLINA SAÑUDO CAMPO, MARIA DEL CARMEN GARCIA IBARBIA, MARIA DEL CARMEN VALERO DIAZ DE LAMADRID, M.F. FRAGA, A.F. FERNÁNDEZ, FLOR MARIA PEREZ CAMPO, MARIA ISABEL PEREZ NUÑEZ, MARIA ESTHER LAGUNA BERCERO, JOSE ANTONIO RIANCHO MORAL

2018

65 results

1 of 3 Next Last

Start year

9 results

Aumento de la capacidad osteogénica de las células madre mesenquimales mediante la modulación del microambiente de la médula ósea

Typology: Competitive national public projects

Start year: 2023

SISTEMA DE ANALISIS DE EXPRESIÓN GENÉTICA A TRAVÉS DE PCR EN TIEMPO REAL (FINANCIADA POR LA CONSEJERÍA DE UNIVERSIDADES, IGUALDAD, CULTURA Y DEPORTE DEL GOBIERNO DE CANTABRIA (CONTRATO PROGRAMA GOBIERNO DE CANTABRIA ? UC).)

Typology: Complementary actions and Infrastructures

Start year: 2022

Terapia génica de la Atrofia Muscular Espinal (SMA): Desarrollo de un sistema de nanopartículas funcionalizadas para la liberación específica de oligonucleótidos en la fibra muscular estriada esquelética

Typology: Agreements and contracts art.83, University and Competitive Chairs UC

Start year: 2022

Desarrollo de una estrategia terapéutica para la regeneración ósea basada en el uso de biosoportes funcionalizados con secretoma de células madre mesenquimales.

Typology: Competitive private projects, competitive autonomic and subcon…

Start year: 2021

Development of a cell-free therapeutic strategy based on Mesenchymal stem cells secretome for bone regeneration.

Typology: Agreements and contracts art.83, University and Competitive Chairs UC

Start year: 2021

PROMOCION DE LA CAPACIDAD OSTEOGENICA DE CELULAS MADRE MESENQUIMALES MEDIANTE LA MODULACION DEL MICROAMBIENTE DE LA MEDULA OSEA

Typology: Competitive national public projects

Start year: 2021

OPTIMIZACIÓN EN OBTENCIÓN, AISLAMIENTO, CULTIVO, CARACTERIZACIÓN Y CRIOPRESERVACIÓN DE CÉLULAS MADRE (CM) PROCEDENTES DE PULPA DENTAL. DESARROLLO DE SISTEMA DE REGENERACIÓN ÓSEA BASADO EN SILENCIAMIENTO DEL GEN SMURF1 EN CM PROCEDENTES DE PULPA DENTAL

Typology: Competitive private projects, competitive autonomic and subcon…

Start year: 2016

BASES GENETICAS DE LA HIPERCOLESTEROLEMIAS HEREDITARIAS NO DEPENDIENTES DEL RECEPTOR LDL NI APOLIPOPROTEINA B. CARACTERIZACION Y ANALISIS FUNCIONAL DE VARIANTES DE LAS REGIONES REGULADORAS 3 DE GENES CANDIDATOS

Typology: Competitive national public projects

Start year: 2013

CONTRIBUCION DE LA VARIABILIDAD EN EL PROMOTOR DEL GEN DEL RECEPTOR DE LDL A LA HIPERCOLESTEROLEMICA POLIGENICA. SUBPROYECTO 4: CARACTERIZACION FUNCIONAL DE LAS VARIANTES EN LA REGION PROMOTORA.