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Detalle GrupoIDI

Sistemas de Secreción Tipo IV Bacterianos

Publications
20
Projects
11
Thesis
8
Patents and technologies
1

Group manager: MATXALEN LLOSA BLAS

INST. DE BIOMEDICINA Y BIOTECNOLOGÍA DE CANTABRIA

FACULTAD DE MEDICINA- AV. CARDENAL HERRERA ORIA

942 201957

Group website

Research lines

Análisis molecular de componentes de sistemas conjugativos - Head: MATXALEN LLOSA BLAS
MODIFICACION GENETICA DE CELULAS DE MAMIFERO MEDIADA POR BACTERIAS - Head: MATXALEN LLOSA BLAS
Reclutamiento de sustratos por Sistemas de Secreción Tipo IV - Head: MATXALEN LLOSA BLAS
Recombinación e integración sitio-específica catalizada por relaxasas conjugativas - Head: MATXALEN LLOSA BLAS

Equipment

Citometría de flujo
Laboratorio de bioseguridad P2

Operating laboratories

LABORATORIO DE INVESTIGACIÓN EN BIOLOGÍA MOLECULAR
Biología y aplicaciones de los sistemas de secreción Tipo IV bacterianos

Collaborating Entities

AGENCIA ESTATAL DE INVESTIGACION
BIOPOLIS SL
COMISION EUROPEA
FUNDACION CIENTIFICA DE LA ASOCIACION ESPAÑOLA CONTRA EL CANCER
MINISTERIO DE CIENCIA, INNOVACION Y UNIVERSIDADES
POLITECHNIKA POZNANSKA
SODERCAN, S.A.
UNIVERSITE POLYTECHNIQUE HAUTS-DE-FRANCE

Members Publications Projects Supervised Theses Patents and technologies

1 results

MATXALEN LLOSA BLAS

Group manager

Catedrático de Universidad

INST. DE BIOMEDICINA Y BIOTECNOLOGÍA DE CANTABRIA

Publications
20
Projects
17
Thesis
8
Patents and technologies
2

1 results

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Year of publication

20 results

Recruitment of heterologous substrates by bacterial secretion systems for transkingdom translocation

Article

Frontiers in Cellular and Infection Microbiology, 2023, 13, 1146000

Authorship: DOLORES LUCÍA GUZMÁN HERRADOR, ANDREA FERNANDEZ GOMEZ, MATXALEN LLOSA BLAS

2023

Conjugative DNA Transfer From E. coli to Transformation-Resistant Lactobacilli

Article

Front Microbiol . 2021 Feb 11;12:606629

Authorship: SARA SAMPERIO, DOLORES LUCÍA GUZMÁN HERRADOR, RIGOBERTO MAY-CUZ, MARIA CRUZ MARTÍN, MIGUEL A. ÁLVAREZ, MATXALEN LLOSA BLAS

2021

Editorial

Other

Plasmid . 2021 Jan;113:102526

Authorship: SUSANA BROM, ELISABETH GROHMAN, MATXALEN LLOSA BLAS

2021

Bacterial injection machines: evolutionary diverse but functionally convergent

Article

Cellular Microbiology, 2020, 22(5), e13157

Authorship: SOPHIE BLEVES, JORGE E. GALÁN, MATXALEN LLOSA BLAS

2020

The secret life of conjugative relaxases

Article

Plasmid Volume 104, July 2019, 102415

Authorship: DOLORES LUCÍA GUZMÁN HERRADOR, MATXALEN LLOSA BLAS

01/07/2019

Exchange of functional domains between a bacterial conjugative relaxase and the integrase of the human adeno-associated virus

Article

PLoS One. 2018 Jul 17;13(7):e0200841

Authorship: LETICIA AGÚNDEZ, FRANCISCO ZÁRATE PÉREZ, ANITA F. MEIER, MARTINO BARDELLI, MATXALEN LLOSA BLAS, CARLOS R. ESCALANTE, R. MICHAEL LINDEN, ELS HENCKAERTS

01/07/2018

The conjugative relaxase TrwC promotes integration of foreign DNA in the human genome

Article

Applied and Environmental Microbiology. 2017, 83(12), e00207-17

Authorship: CORAL GONZALEZ PRIETO, RICHARD GABRIEL, CHRISTOPH DEHIO, MANFRED SCHMIDT, MATXALEN LLOSA BLAS

01/06/2017

DNA delivery and genomic integration into mammalian target cells through type iv a and b secretion systems of human pathogens

Article

Frontiers in Microbiology, 2017, 8, 1503

Authorship: DOLORES LUCÍA GUZMÁN HERRADOR, SAMUEL STEINER, ANABEL ALPERI, CORAL GONZALEZ PRIETO, CRAIG R. ROY, MATXALEN LLOSA BLAS

22/08/2017

Substrate translocation involves specific lysine residues of the central channel of the conjugative coupling protein TrwB

Article

Molecular Genetics and Genomics, 2017, 292(5), 1037-1049

Authorship: DELFINA LARREA, HECTOR DAVID PAZ FERNANDEZ, MARIA INMACULADA MATILLA FERNANDEZ, DOLORES LUCÍA GUZMÁN HERRADOR, GORKA LASSO, FERNANDO DE LA CRUZ CALAHORRA, MARIA ELENA CABEZON NAVARRO, MATXALEN LLOSA BLAS

01/10/2017

Coupling Proteins in Type IV Secretion

Book part

Type IV secretion in gram-negative and gram-positive bacteria

Authorship: MATXALEN LLOSA BLAS, ITZIAR ALKORTA

2017

A functional oriT in the Ptw plasmid of Burkholderia cenocepacia can be recognized by the R388 relaxase TrwC

Article

Frontiers in Molecular Biosciences, 2016, 3, 16

Authorship: ESTHER FERNANDEZ GONZALEZ, SAWSANE BAKIOUI, MARGARIDA C. GOMES, DAVID O´CALLAGHAN, ANNETTE C. VERGUNST, FELIX JAVIER SANGARI GARCIA, MATXALEN LLOSA BLAS

2016

Chloramphenicolselection of is10 transposition in the cat promoter region of widely used cloning vectors

Article

PLoS One. 2015, 10(9), e0138615

Authorship: CORAL GONZALEZ PRIETO, LETICIA AGUNDEZ CORTES, MATXALEN LLOSA BLAS

01/09/2015

Structural independence of conjugative coupling protein TrwB from its Type IV secretion machinery

Article

Plasmid, 2013, 70(1), 146-53

Authorship: DELFINA LARREA, HECTOR DAVID PAZ FERNANDEZ, IGNACIO MARIA ARECHAGA ITURREGUI, FERNANDO DE LA CRUZ CALAHORRA, MATXALEN LLOSA BLAS

2013

A translocation motif in relaxase trwc specifically affects recruitment by its conjugative type IV Secretion System

Article

Journal of Bacteriology, 2013, 195(22), 4999-5006

Authorship: ANABEL ALPERI VEGA, DELFINA LARREA, ESTHER FERNANDEZ GONZALEZ, CHRISTOPH DEHIO, ELLEN L. ZECHNER, MATXALEN LLOSA BLAS

01/11/2013

HUH site-specific recombinases for targeted modification of the human genome

Article

Trends in Biotechnology, 2013, 31(5), 305-312

Authorship: CORAL GONZALEZ PRIETO, LETICIA AGUNDEZ CORTES, RALPH MICHAEL LINDEN, MATXALEN LLOSA BLAS

01/05/2013

Site-specific integration of foreign dna into minimal bacterial and human target sequences mediated by a conjugative relaxase

Article

PLoS ONE, 2012, 7(1), e31047

Authorship: LETICIA AGUNDEZ CORTES, CORAL GONZALEZ PRIETO, CRISTINA MACHON SOBRADO, MATXALEN LLOSA BLAS

01/01/2012

New perspectives into bacterial DNA transfer to human cells

Article

Trends in Microbiology, 2012, 20(8), 355-359

Authorship: MATXALEN LLOSA BLAS, GUNNAR SCHRÖDER, CHRISTOPH DEHIO

01/08/2012

Nuclear targeting of a bacterial integrase that mediates site-specific recombination between bacterial and human target sequences

Article

Applied and Environmental Microbiology, 2011, 77(1), 201.-210

Authorship: LETICIA AGUNDEZ CORTES, CRISTINA MACHON SOBRADO, CAROLINA ELVIRA CESAR, MANUEL ROSA GARRIDO, MARIA DOLORES DELGADO VILLAR, MATXALEN LLOSA BLAS

01/01/2011

Transfer of R388 derivatives by a pathogenesis-associated type IV secretion system into both bacteria and human cells

Article

Journal of Bacteriology, 2011, 193(22), 6257-6265

Authorship: ESTHER FERNANDEZ GONZALEZ, HECTOR DAVID PAZ FERNANDEZ, ANABEL ALPERI VEGA, LETICIA AGUNDEZ CORTES, MARCO FAUSTMANN, FELIX JAVIER SANGARI GARCIA, CHRISTOPH DEHIO, MATXALEN LLOSA BLAS

01/11/2011