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Membrane-associated nanomotors for macromolecular transport

Abstract: Nature has endowed cells with powerful nanomotors to accomplish intricate mechanical tasks, such as the macromolecular transport across membranes occurring in cell division, bacterial conjugation, and in a wide variety of secretion systems. These biological motors couple the chemical energy provided by ATP hydrolysis to the mechanical work needed to transport DNA and/or protein effectors. Here, we review what is known about the molecular mechanisms of these membrane-associated machines. Sequence and structural comparison between these ATPases reveal that they share a similar motor domain, suggesting a common evolutionary ancestor. Learning how these machines operate will lead the design of nanotechnology devices with unique applications in medicine and engineering.

 Authorship: Cabezon E., Lanza V., Arechaga I.,

 Fuente: Current Opinion in Biotechnology, 2012, 23(4), 537-44

 Publisher: Elsevier

 Year of publication: 2012

 No. of pages: 8

 Publication type: Article

 DOI: 10.1016/j.copbio.2011.11.031

 ISSN: 0958-1669,1879-0429

 Spanish project: BFU2008-00806

 Publication Url: