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Functional, structural, and molecular remodelling of the goldfish (Carassius auratus) heart under moderate hypoxia

Abstract: The goldfish (Carassius auratus) is known for its physiologic ability to survive even long periods of oxygen limitation (hypoxia), adapting the cardiac performance to the requirements of peripheral tissue perfusion. We here investigated the effects of short-term moderate hypoxia on the heart, focusing on ventricular adaptation, in terms of hemodynamics and structural traits. Functional evaluations revealed that animals exposed to 4 days of environmental hypoxia increased the hemodynamic performance evaluated on ex vivo cardiac preparations. This was associated with a thicker and more vascularized ventricular compact layer and a reduced luminal lacunary space. Compared to normoxic animals, ventricular cardiomyocytes of goldfish exposed to hypoxia showed an extended mitochondrial compartment and a modulation of proteins involved in mitochondria dynamics. The enhanced expression of the pro-fission markers DRP1 and OMA1, and the modulation of the short and long forms of OPA1, suggested a hypoxia-related mitochondria fission. Our data propose that under hypoxia, the goldfish heart undergoes a structural remodelling associated with a potentiated cardiac activity. The energy demand for the highly performant myocardium is supported by an increased number of mitochondria, likely occurring through fission events.

 Authorship: Filice M., Gattuso A., Imbrogno S., Mazza R., Amelio D., Caferro A., Agnisola C., Icardo J.M., Cerra M.C.,

 Fuente: Fish Physiology and Biochemistry, 2024, 50, 667-685

 Publisher: Springer

 Year of publication: 2024

 No. of pages: 19

 Publication type: Article

 DOI: 10.1007/s10695-024-01297-7

 ISSN: 0920-1742,1573-5168

 Publication Url: https://doi.org/10.1007/s10695-024-01297-7

Authorship

FILICE, MARIACRISTINA

GATTUSO, ALFONSINA

IMBROGNO, SANDRA

MAZZA, ROSA

AMELIO, DANIELA

CAFERRO, ALESSIA

CERRA, MARIA CARMELA