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Multispectral Muller matrix imaging: a potential tool to visualize white matter tracts

Abstract: In this study, we applied Multispectral Mueller Matrix Imaging (MMI) at six distinct wavelengths in the visible range to analyze brain structures using lamb cerebral samples. The imaging of several brain sections revealed that white matter (WM) exhibits pronounced depolarization and retardance when contrasted with grey matter (GM), a phenomenon likely attributed to the elevated scattering and anisotropic nature of WM. More precisely, with an increase in wavelength, both depolarization and retardance also increase, suggesting additional penetration into deeper tissue layers. Employing various wavelengths enabled us to trace the shifts in the optical axis of retardance within the brain tissue, offering insights into the morphological changes in WM and GM below the cortical surface. The consistency observed in our results highlights the promise of Multispectral Wide-Field MMI as a non-intrusive, efficacious modality for probing brain architecture.

Other conference communications or articles related to authors from the University of Cantabria

 Authorship: Mieites V., Anichini G., Qi J., O'Neill K., Conde O.M., Elson D.S.,

 Congress: Tissue Optics and Photonics (3º : 2024 : Estrasburgo, Francia)

 Publisher: SPIE Society of Photo-Optical Instrumentation Engineers

 Publication date: 01/04/2024

 No. of pages: 5

 Publication type: Conference object

 DOI: 10.1117/12.3017499

 ISSN: 0277-786X,1996-756X

 Spanish project: TED2021-130378B-C21

 Publication Url: https://doi.org/10.1117/12.3017499

Authorship

VERONICA MIEITES ALONSO

ANICHINI, GIULIO

QI, JI

O'NEILL, KEVIN