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A genome-wide association meta-analysis of all-cause and vascular dementia

Abstract: Methods: We conducted a GWAS of all-cause dementia (ACD) and examined the genetic overlap with VaD. Our dataset includes 800,597 individuals, with 46,902 and 8702 cases of ACD and VaD, respectively. Known AD loci for ACD and VaD were replicated. Bioinformatic analyses prioritized genes that are likely functionally relevant and shared with closely related traits and risk factors. Results: For ACD, novel loci identified were associated with energy transport (SEMA4D), neuronal excitability (ANO3), amyloid deposition in the brain (RBFOX1), and magnetic resonance imaging markers of small vessel disease (SVD; HBEGF). Novel VaD loci were associated with hypertension, diabetes, and neuron maintenance (SPRY2, FOXA2, AJAP1, and PSMA3). Discussion: Our study identified genetic risks underlying ACD, demonstrating overlap with neurodegenerative processes, vascular risk factors, and cerebral SVD.

 Fuente: Alzheimer's & Dementia: the Journal of the Alzheimer's Association, 2024, 20, 5973-5995

 Publisher: John Wiley & Sons

 Year of publication: 2024

 No. of pages: 23

 Publication type: Article

 DOI: 10.1002/alz.14115

 ISSN: 1552-5260,1552-5279

 Publication Url: https://doi.org/10.1002/alz.14115

Authorship

FONGANG, BERNARD

SARGURUPREMRAJ, MURALIDHARAN

JIAN, XUEQIU

MISHRA, ANIKET

DAMOTTE, VINCENT

ROJAS, ITIZIAR DE

SKROBOT, OLIVIA

BIS, JOSHUA C.

FAN, KANG-HSIEN

JACOBSEN, ERIN

LI, GLORIA HOI-YEE

YAN, JINGYUN

ALESSANDRA, BIZZARRO

ALESSANDRA, LAURIA

HILAL, SAIMA

CHONG, JOYCE RUIFEN

CHAI, YUEK LING

KNOL, M. J.