Abstract: Introduction and objectives: Cardiovascular disease accounts for a considerable proportion of both morbidity and mortality. In addition to well-established risk factors, some studies have identified a correlation between social determinants such as social support, income, and psychosocial factors and worse outcomes. Methods: A prospective, single-centre observational study was conducted on patients diagnosed with coronary disease following coronary angiography. In addition to traditional risk factors, social determinants were collected via a researcher-administered questionnaire. Clinical events were prospectively recorded. A composite endpoint was defined as cardiovascular death, myocardial infarction (MI), or coronary revascularization. A multivariate Cox proportional hazards regression analysis was conducted using variables selected from the univariate analysis. Results: A total of 2213 patients were followed for a median duration of 1461 days. The mean age of the cohort was 66.3 years; 23.5% were women, 27.8% had diabetes mellitus, and 10.4% had chronic kidney disease. During the follow-up period, there were 343 (15.5%) composite endpoint events, including 109 (4.9%) deaths, 85 (4%) cardiovascular deaths, 182 (8.2%) MI, 229 (10.3%) revascularizations, 70 (3.2%) strokes, and 129 (5.8%) clinically significant haemorrhages. The multivariate analysis revealed that 2 social variables were significantly associated with the composite endpoint: self-management of treatment (aHR, 0.61; 95%CI, 0.44-0.85; P < .01) and home Internet access (aHR, 0.73; 95%CI, 0.56-0.97; P = .013). Conclusions: Certain social factors, such as self-management of treatment and internet access, are associated with a better prognosis in patients with ischemic heart disease. Identification of these patients would enable healthcare professionals to potentially improve prognosis.

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