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JOSE PEDRO VAQUE DIEZ

  • Publications

    30

  • Projects

    8

  • Thesis

    5

  • Patents and technologies

    1

I am a molecular biologist interested in studying the molecular mechanisms that govern the biology of cancer. I hold a Bs. In biology (U. Navarra, 1997), a MS and a PhD in molecular biology (U. Cantabria 1998 and 2006). After a 5 year post-doctoral training at the NIH (Bethesda, USA), I was recruited by IDIVAL (Santander, 2011). Since 2015, I lead my own research thanks to a RyC contract and a Prof. Titular_I3 appointment at the UC (Laboratory of Signaling Mechanisms and Biology Of Cancer).

My scientific activity has evolved from the basic field (transcriptional and signaling mechanisms) to translationally-oriented research projects in human cancers with limited survival, that lack markers for diagnosis and/or specific therapy.

We have obtained funding from 4 FIS projects (PI: JP Vaqué 2013-2026) and two PIEs (2015-2019). Also, we have been funded by Asociación Luchamos Por La Vida (Los Corrales de Buelna, 2013-2020). Our academic activity has enabled the obtention of 5 PhDs and 8 MSs.

MAIN SCIENTIFIC ACHIEVEMENTS:

1. Precision diagnosis and targeted therapy of Cutaneous T Cell Lymphomas (CTCL): We are depicting an activated network of deregulated signaling mechanisms controls the biology of CTCLs. Of these, mutated PLCG1 activates NFAT via calcineurin (CaN) which constitutes a mayor disease mechanism (Vaqué JP et al. Blood 2014). In parallel, deregulated JAK/STAT signaling promotes cancer progression (Perez C. et al. Haematologica 2015, Perez C. et al. BJD 2020 and García-Díaz N. et al. Cancers 2021). Later, we discover that PKC-Theta interconnects PLCG1-CaN and JAK/STAT signaling, and constitutes a key mechanism controlling CTCL development and dissemination (García-Diaz N. et al. JID 2022, Alonso-Alonso R et al BJD, 2023). In pacients, a clinical trial (phase II), revealed the activity (ORR, 60%) and safety of topical Pimecrolimus (a specific CaN inhibitor) in CTCL patients at initial stages of the disease (Ortiz-Romero PL. et al. Lancet Haematology 2022).

2. Identification of activated CREB as independent adverse marker for Merkel Cell Carcinoma patients (González-Vela MC and Curiel-Olmo S. et al. JID 2017)

3. Novel approaches for molecular diagnosis and targeted therapy of Advanced Cutaneous Melanoma and Hepatocellular Carcinoma (Curiel-Olmo S et al . Oncotarget 2015 and Llerena S and García-Diaz N. Oncotarget 2018).

4. Depicted GNAQ downstream signaling network in Uveal Melanoma (Vaqué JP et al. Mol. Cell, 2013, Feng X. et al. Can. Cell 2014).

5. Transcriptional control of gene expression by MYC independently of MAX (Vaqué JP et al. MCR., 2008). MYC-mediated transcriptional modulation of exacerbated RAS-oncogenic signaling (Delgado MD et al. Oncogene 2000, Vaqué JP et al. JBC, 2004)

 jose.vaque@unican.es

 Facultad de Medicina. Avda. Cardenal Herrera Oria, 2. 39011 Santander

Profesor Titular de Universidad

Doctor por la Universidad de Cantabria

 Grupo De Mecanismos Directores Y Fisiopatología De Cáncer Humano Y Enfermedades De La Piel -TRANS_SKIN

 DEPARTAMENTO DE BIOLOGÍA MOLECULAR

Specialty areas: BIOQUIMICA Y BIOLOGIA MOLECULAR

Identifiers

Other names in publications
  • Vaque, Jose P.
  • Vaqué, Jose Pedro
  • Vaqué, Jose P.
  • Vaqué, J. P.
  • Vaqué, José P.
  • Vaque, José P.
  • Vaqué, J. Pedro
  • Vaque, Jose Pedro
  • Vaqué, José
  • Pedro Vaqué, José
  • Vaqué, Josep
  • Vaque, Josep
  • Vaqué, J.
  • Vaque, J.
  • Vaqué Díez, José P.
  • Vaque, José Pedro
30 results 
    1 of 2  Next  Last

Increased risk of MAFLD and liver fibrosis in inflammatory bowel disease Independent of classic metabolic risk factors

Article

Clinical Gastroenterology and Hepatology, 2023, 21(2), 406-414

 Authorship: JUAN CARLOS RODRÍGUEZ-DUQUE, JOSÉ LUIS CALLEJA, PAULA IRUZUBIETA COZ, MARTA HERNÁNDEZ-CONDE, CORAL RIVAS-RIVAS, MARÍA ISABEL VERA, MARÍA JOSÉ GARCÍA, MARTA PASCUAL, BEATRIZ CASTRO, AGUSTIN GARCIA BLANCO, ENRIQUE GARCÍA-NIETO, SORAYA CURIEL DEL OLMO, MARIA LUISA CAGIGAL COBO, LORENA LÓPEZ-MONTEJO, TATIANA FERNÁNDEZ-LAMAS, LAURA RASINES, JOSE IGNACIO FORTEA ORMAECHEA, JOSE PEDRO VAQUE DIEZ, YZA FRÍAS, MONTSERRAT RIVERO TIRADO, MARIA TERESA ARIAS LOSTE, JAVIER CRESPO GARCIA

 2023

NanoString analysis of mycosis fungoides reveals individual molecular identity

Article

British Journal of Dermatology, 2023, 188(6), 812-815

 Authorship: RUTH ALONSO-ALONSO, MARTA RODRÍGUEZ, NURIA GARCIA DIAZ, LAURA TOMÁS-ROCA, JENNIFER BORREGÓN, MARTA CABEZUELO-RODRÍGUEZ, MARCOS REBOLLO-GONZÁLEZ, LUIS GALLEGO-MANZANO, LAURA CERECEDA, SOCORRO MARÍA RODRÍGUEZ-PINILLA, RAÚL CÓRDOBA, JUAN FERNANDO GARCÍA, JUAN TORRE-CASTRO, CARMEN M. GARCÍA-ÁLVAREZ, MARÍA DEL MAR ONTENIENTE GOMIS, RAQUEL RIVERA-DÍAZ, JOSÉ LUIS RODRÍGUEZ-PERALTO, PABLO LUIS ORTIZ-ROMERO, JOSE PEDRO VAQUE DIEZ

 2023

PLCy1/PKC0 Downstream Signaling Controls Cutaneous T-Cell Lymphoma Development and Progression

Article

J Invest Dermatol . 2022 May;142(5):1391-1400.e15

 Authorship: NURIA GARCIA DIAZ, BERTA CASAR MARTINEZ, RUTH ALONSO-ALONSO, LAURA QUEVEDO PALACIO, MARTA RODRÍGUEZ, FULGENCIO RUSO JULVE, ANNA ESTEVE-CODINA, MARTA GUT, ALEJANDRO A. GRU, MARIA CARMEN GONZALEZ VELA, IVO GUT, JOSÉ LUIS RODRIGUEZ-PERALTO, IGNACIO VARELA EGOCHEAGA, PABLO LUIS ORTIZ-ROMERO, MIGUEL A. PIRIS, JOSE PEDRO VAQUE DIEZ

 2022

Activity and safety of topical pimecrolimus in patients with early stage mycosis fungoides (PimTo-MF): a single-arm, multicentre, phase 2 trial

Article

Lancet Haematol . 2022 Jun;9(6):e425-e433

 Authorship: PABLO L ORTIZ-ROMERO, LIDIA MAROÑAS JIMÉNEZ, CRISTINA MUNIESA, TERESA ESTRACH, OCTAVIO SERVITJE, RICARDO FERNÁNDEZ-DE-MISA, FERNANDO GALLARDO, ONOFRE SANMARTÍN, ERICA RIVEIRO-FALKENBACH, NURIA GARCÍA-DÍAZ, ROSA VEGA, DAVID LORA, CONCEPCIÓN POSTIGO, BLANCA JIMÉNEZ, MARGARITA SÁNCHEZ-BEATO, JOSE PEDRO VAQUE DIEZ, JOSÉ LUIS RODRÍGUEZ PERALTO, AGUSTÍN GÓMEZ DE LA CÁMARA, JAVIER DE LA CRUZ, MIGUEL ÁNGEL PIRIS PINILLA

 2022

Mycosis fungoides and sézary syndrome: an integrative review of the pathophysiology, molecular drivers, and targeted therapy

Article

Cancers, 2021, 13(8), 1931

 Authorship: NURIA GARCIA DIAZ, MIGUEL ÁNGEL PIRIS, PABLO LUIS ORTIZ-ROMERO, JOSE PEDRO VAQUE DIEZ

 2021

Advanced-stage mycosis fungoides: role of the signal transducer and activator of transcription 3, nuclear factor-kB and nuclear factor of activated T cells pathways

Article

British Journal of Dermatology, 2020, 182(1), 147-155

 Authorship: C. PÉREZ, R. MONDÉJAR, N. GARCÍA-DÍAZ, L. CERECEDA, A. LEÓN, S. MONTES, C. DURÁN VIAN, M.G. PÉREZ PAREDES, A. GONZÁLEZ-MORÁN, V. ALEGRE DE MIGUEL, J.M. SANZ ANQUELA, J. FRIAS, M.A. LIMERES, L.M. GONZÁLEZ, F. MARTÍN DÁVILA, M. BELTRÁN, M. MOLLEJO, J.R. MÉNDEZ, M.A. GONZÁLEZ, JOSE PEDRO VAQUE DIEZ

 01/01/2020

Identification of Tipifarnib Sensitivity Biomarkers in T-cell Acute Lymphoblastic Leukemia and T-cell Lymphoma

Article

Sci Rep . 2020 Apr 21;10(1):6721

 Authorship: RUTH ALONSO-ALONSO, RUFINO MONDÉJAR, NEREA MARTÍNEZ, NURIA GARCÍA-DIAZ, CRISTINA PÉREZ, DAVID MERINO, MARTA RODRÍGUEZ, ANNA ESTEVE-CODINA, BERTA FUSTE, MARTA GUT, FRANCIS BURROWS, CATHERINE SCHOLZ, JOSE PEDRO VAQUE DIEZ, ANTONIO GUALBERTO, MIGUEL ÁNGEL PIRIS

 2020

The presence of Merkel cell carcinoma polyomavirus is associated with a distinct phenotype in neoplastic Merkel cell carcinoma cells and their tissue microenvironment

Article

PLoS One . 2020 Jul 20;15(7):e0232517

 Authorship: MARÍA DOLORES MENDOZA, CARLOS SANTONJA, MARIA CARMEN GONZALEZ VELA, ÁNGEL CONCHA, NICOLÁS IGLESIAS PENA, EVA MARÍA ANDRÉS ESTEBAN, JOSE PEDRO VAQUE DIEZ, LAURA CERECEDA, RAQUEL PAJARES, H. KUTZNER, LUIS REQUENA, MIGUEL A. PIRIS

 2020

Dopaminergic control of ADAMTS2 expression through cAMP/CREB and ERK: molecular effects of antipsychotics

Article

Translational Psychiatry, 2019, 9(1), 306

 Authorship: FULGENCIO RUSO-JULVE, ANA POMBERO, MARIA FUENCISLA PILAR CUELLAR, NURIA GARCÍA-DÍAZ, RAQUEL GARCIA-LOPEZ, MARÍA JUNCAL-RUIZ, MARIA ELENA CASTRO FERNANDEZ, ALVARO MARCELINO DIAZ MARTINEZ, JAVIER VAZQUEZ BOURGON, AGUSTÍN GARCÍA-BLANCO, EMILIO GARRO-MARTINEZ, HELENA PISONERO, ALICIA ESTIRADO, ROSA AYESA-ARRIOLA, JUAN LÓPEZ-GIMÉNEZ, FEDERICO MAYOR JR., ELSA VALDIZÁN, JAVIER MEANA, JAVIER GONZALEZ-MAESO, SALVADOR MARTÍNEZ, JOSE PEDRO VAQUE DIEZ, BENEDICTO CRESPO FACORRO

 2019

Applied diagnostics in liver cancer: efficient combinations of sorafenib with targeted inhibitors blocking AKT/mTOR

Article

Oncotarget, 2018, 9(56), 30869-30882

 Authorship: SUSANA LLERENA SANTIAGO, NURIA GARCIA DIAZ, SORAYA CURIEL DEL OLMO, ANTONIO MANUEL AGRAZ DOBLAS, AGUSTIN GARCIA BLANCO, HELENA PISONERO FRAGA, MARÍA VARELA, MIGUEL SANTIBAÑEZ MARGÜELLO, CARMEN ALMARAZ, LAURA CERECEDA, NEREA MARTÍNEZ, MARIA TERESA ARIAS LOSTE, ÁNGELA PUENTE, LUIS MARTIN RAMOS, CARLOS RODRIGUEZ DE LOPE MARTIN, FEDERICO JOSE CASTILLO SUESCUN, CARMEN CAGIGAS FERNANDEZ, PABLO ISIDRO, CARLOS RODRIGUEZ DE LOPE LOPEZ, MARCOS LOPEZ HOYOS, FRANCISCO JAVIER LLORCA DIAZ, JESUS AGÜERO BALBIN, BENEDICTO CRESPO FACORRO, IGNACIO VARELA EGOCHEAGA, MIGUEL ÁNGEL PIRIS, JAVIER CRESPO GARCIA, JOSE PEDRO VAQUE DIEZ

 2018

Deregulated mechanisms downstream of PLCG1 promoting cutaneous T cell lymphoma progression

Conference object

ESMO Open 2018;3(Suppl 2):A220

 Authorship: N. GARCÍA DÍAZ, C. PÉREZ, R. MONDÉJAR, A. GRU, R. ALONSO ALONSO, HELENA PISONERO FRAGA, L. CERECEDA, P. ORTIZ ROMERO, M.A. PIRIS, JOSE PEDRO VAQUE DIEZ

 2018

Shared Oncogenic Pathways Implicated in Both Virus-Positive and UV-Induced Merkel Cell Carcinomas

Article

Journal of Investigative Dermatology Volume 137, Issue 1, January 2017, Pages 197-206

 Authorship: MARIA CARMEN GONZALEZ VELA, SORAYA CURIEL OLMO, SOPHIA DERDAK, SERGI BELTRAN, MIGUEL SANTIBAÑEZ MARGÜELLO, NEREA MARTÍNEZ, ALFREDO CASTILLO TRUJILLO, MARTHA GUT, ROXANA SÁNCHEZ PACHECO, CARMEN ALMARAZ, LAURA CERECEDA, BEATRIZ LLOMBART, ANTONIO MANUEL AGRAZ DOBLAS, JOSÉ REVERT ARCE, JOSÉ ANTONIO LÓPEZ GUERRERO, MANUELA MOLLEJO, PABLO ISIDRO MARRÓN, PABLO ORTIZ ROMERO, LYNNETTE FERNÁNDEZ CUESTA, IGNACIO VARELA EGOCHEAGA, IVO GUT, LORENZO CERRONI, MIGUEL ANGEL PIRIS PINILLA, JOSE PEDRO VAQUE DIEZ

 2017

Molecular basis of targeted therapy in T/NKcell lymphoma/leukemia: A comprehensive genomic and immunohistochemical analysis of a panel of 33 cell lines

Article

PLoS One. 2017 May 15;12(5): e0177524

 Authorship: RUFINO MONDEJAR, CRISTINA PÉREZ, ARANTZA ONAINDIA PEREZ, NEREA MARTÍNEZ, JULIA GONZÁLEZ RINCÓN, HELENA PISONERO, JOSE PEDRO VAQUE DIEZ, LAURA CERECEDA, MIGUEL SANTIBAÑEZ MARGÜELLO, MARGARITA SÁNCHEZ BEATO, MIGUEL ANGEL PIRIS PINILLA

 15/05/2017

Splenic diffuse red pulp small B-cell lymphoma displays increased expression of cyclin D3 and recurrent CCND3 mutations

Article

Blood. 2017 Feb 23;129(8):1042-1045

 Authorship: SORAYA CURIEL DEL OLMO, RUFINO MONDÉJAR, CARMEN ALMARAZ, MANUELA MOLLEJO, LAURA CERECEDA, ROSO MARÉS, SOPHIA DERDAK, YOLANDA CAMPOS MARTÍN, MARIA ANA BATLLE LOPEZ, SONIA GONZALEZ DE VILLAMBROSIA, MARTA GUT, JULIE BLANC, ALEXANDRA TRAVERSE GLEHEN, AURELIE VERNEY, LUCILE BASEGGIO, FRANCISCA I. CAMACHO, ANDREW WOTHERSPOON, KOSTAS STAMATOPOULOS, JOSE PEDRO VAQUE DIEZ, MIGUEL ANGEL PIRIS PINILLA

 23/02/2017

Mutated JAK kinases and deregulated STAT activity are potential therapeutic targets in cutaneous T-cell lymphoma

Article

Haematologica. 2015 Nov;100(11):e450-3

 Authorship: CRISTINA PEREZ MENENDEZ, JULIA GONZÁLEZ RINCÓN, ARANTZA ONAINDIA PEREZ, CARMEN ALMARAZ PRO, NURIA GARCIA DIAZ, HELENA PISONERO FRAGA, SORAYA CURIEL DEL OLMO, SAGRARIO GÓMEZ DE BENITO, LAURA CERECEDA COMPANY, REBECA MADUREIRA RIVERO, MERCEDES HOSPITAL GIL, DOLORES SUÁREZ MASSA, JOSÉ L. RODRIGUEZ PERALTO, CONCEPCIÓN POSTIGO LLORENTE, ALICIA LEÓN CASTILLO, MARIA CARMEN GONZALEZ VELA, NEREA MARTINEZ MAGUNACELAYA, PABLO ORTIZ ROMERO, MARGARITA SÁNCHEZ BEATO, MIGUEL ANGEL PIRIS PINILLA, JOSE PEDRO VAQUE DIEZ

 01/11/2015

Individualized strategies to target specific mechanisms of disease in malignant melanoma patients displaying unique mutational signatures

Article

Oncotarget, 2015, 6(28), 25452-25465 - (ERRATUM), 2016, 7(5), 6352

 Authorship: SORAYA CURIEL DEL OLMO, ALMUDENA GARCÍA CASTAÑO, REBECA VIDAL CASADO, HELENA PISONERO FRAGA, IGNACIO VARELA EGOCHEAGA, ALICIA LEÓN CASTILLO, EUGENIO TRILLO BOHAJAR, MARÍA DEL CARMEN GONZÁLEZ VELA, NURIA GARCÍA DÍAZ, CARMEN ALMARÁZ, THAIDY MORENO RODRIGUEZ, LAURA CERECEDA COMPANY, REBECA MADUREIRA RIVERO, NEREA MARTÍNEZ SECO, PABLO ORTÍZ ROMERO, ELSA MARIA VALDIZAN RUIZ, MIGUEL ÁNGEL PIRIS PINILLA, JOSE PEDRO VAQUE DIEZ

 22/09/2015

Colorectal adenomas contain multiple somatic mutations that do not coincide with synchronous adenocarcinoma specimens

Article

PLoS One, 2015, 10(3), e0119946 - (CORRECTION), 2015, 10(4), e0125459

 Authorship: JOSE PEDRO VAQUE DIEZ, NEREA MARTÍNEZ, IGNACIO VARELA EGOCHEAGA, FIDEL ANGEL FERNANDEZ FERNANDEZ, MARTA M. MAYORGA FERNANDEZ, SOPHIA DERDAK, SERGI BELTRÁN, THAIDY MORENO RODRIGUEZ, CARMEN ALMARÁZ, GONZALO DE LAS HERAS CASTAÑO, MÓNICA BAYÉS, IVO GUT, JAVIER CRESPO GARCIA, MIGUEL ANGEL PIRIS PINILLA

 2015

B-cell lymphoma mutations: improving diagnostics and enabling targeted therapies

Article

Haematologica. 2014 Feb; 99(2): 222–231

 Authorship: JOSE PEDRO VAQUE DIEZ, NEREA MARTINEZ MAGUNACELAYA, MARIA ANA BATLLE LOPEZ, CRISTINA PEREZ MENENDEZ, SANTIAGO MONTES MORENO, MARGARITA SÁNCHEZ BEATO, MIGUEL ANGEL PIRIS PINILLA

 01/02/2014

Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry

Article

Cancer Cell, 2014, 16, 25(6), 831-45

 Authorship: XIAODONG FENG, MARIA SOL DEGESE, RAMIRO IGLESIAS BARTOLOME, JOSE PEDRO VAQUE DIEZ, ALFREDO A. MOLINOLO, MURILO RODRIGUES, M. RAZA ZAIDI, BRUCE R. KSANDER, GLENN MERLINO, AKRIT SODHI, QIANMING CHEN, SILVIO GUTKIND

 16/06/2014

Whole-exome sequencing in splenic marginal zone lymphoma reveals mutations in genes involved in marginal zone differentiation

Article

Leukemia, 2014, 28(6), 1334-1340

 Authorship: NEREA GONZÁLEZ FERNÁNDEZ, CARMEN ALMARÁZ PRO, JOSE PEDRO VAQUE DIEZ, IGNACIO VARELA EGOCHEAGA, SOPHIA DERDAK, SERGI BELTRÁN AGULLÓ, MANUELA MOLLEJO, YOLANDA CAMPOS MARTÍN, LÍDIA ÁGUEDA, ANDREA RINALDI, IVO KWEE, M. GUT, JULIE BLANC, DAVID OSCIER, JONATHAN C. STREFFORD, JOAQUÍN MARTÍNEZ LÓPEZ, ANTONIO SALAR, FRANCESC SOLÉ, JOSE LUIS RODRÍGUEZ PERALTO, CRISTINA DIEZ TASCÓN, JUAN FERNANDO GARCÍA GARCÍA, MÁXIMO FRAGA RODRÍGUEZ, E. SEBASTIAN, FRANCISCO JAVIER ÁLVES FERREIRA, JAVIER MENÁRGUEZ PALANCA, JOAQUÍN GONZÁLEZ-CARRERÓ, L. FELIPE CASADO, BAYÈS MÓNICA, FRANCESCO BERTONI, IVO GUT, MIGUEL ANGEL PIRIS PINILLA

 01/06/2014

PLCG1 mutations in cutaneous T-cell lymphomas

Article

Blood, 2014, 123(13), 2034-2043

 Authorship: JOSE PEDRO VAQUE DIEZ, GONZALO GÓMEZ LÓPEZ, VERÓNICA MONSÁVEZ, IGNACIO VARELA EGOCHEAGA, NEREA MARTINEZ SECO, CRISTINA PÉREZ, ORLANDO DOMÍNGUEZ, OSVALDO GRAÑA, JOSÉ LUIS RODRÍGUEZ PERALTO, SOCORRO M RODRÍGUEZ PINILLA, MARIA CARMEN GONZALEZ VELA, MIRIAM RUBIO CAMARILLO, ESPERANZA MARTÍN SÁNCHEZ, DAVID G PISANO, EVANGELIA PAPADAVI, THEODORA PAPADAKI, LUIS REQUENA, JOSÉ A GARCÍA MARCO, MIRIAM MENDEZ, MARIANO PROVENCIO, MERCEDES HOSPITAL, DOLORES SUÁREZ MASSA, CONCEPCIÓN POSTIGO, DAVID SAN SEGUNDO ARRIBAS, MARCOS LOPEZ HOYOS, PABLO L ORTÍZ ROMERO, MIGUEL ANGEL PIRIS PINILLA, MARGARITA SÁNCHEZ BEATO

 2014

MYC antagonizes the differentiation induced by imatinib in chronic myeloid leukemia cells through downregulation of p27 KIP1

Article

Oncogene, 2013, 32(17), 2239-2246

 Authorship: M. T. GÓMEZ-CASARES, EVA GARCIA ALEGRIA, C. E. LÓPEZ-JORGE, NURIA FERRANDIZ DIAZ, ROSA FERNANDA BLANCO FERNÁNDEZ, S. ÁLVAREZ, JOSE PEDRO VAQUE DIEZ, GABRIEL BRETONES SANCHEZ, JUAN MANUEL CARABALLO OTERO, P. SÁNCHEZ-BAILÓN, MARIA DOLORES DELGADO VILLAR, J. MARTÍN-PÉREZ, J. C. CIGUDOSA, JAVIER LEON SERRANO

 01/04/2013

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