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JAVIER LEON SERRANO

  • Publications

    34

  • Projects

    15

  • Thesis

    21

  • Patents and technologies

    3

Javier León (Madrid, 1955) was Graduated in Biological Sciences and Graduated in Pharmacy in the Universidad Complutense. He also holds the title of Specialist in Microbiology (FIR, Hospital Marqués de Valdecilla, Santander). He defended his PhD Thesis in 1983 and did the postdoctoral research in New York University Cancer Center (1984- 1986). In 1986 got the position of “Profesor Titular” of Biochemistry and Molecular Biology in the University of Cantabria and in 1994 the position of “Catedrático”. In 2007 he joined the Instituto de Biomedicina y Biotecnología (IBBTEC), a joint center Universidad de Cantabria-CSIC. He has worked as visiting scientist for a total of 2.5 years in Fred Hutchinson Cancer Research Center (Seattle) and Dana Farber Cancer Institute/Harvard Cancer Center (Boston).

His group was established in 1983 and has been funded by 13 consecutive grants from “Plan Estatal de I+D” as IP, as well as equipment grants and local grants. He has supervised 21 PhD Thesis and published 96 research papers in indexed journals, being first or corresponding author in 64 of them. His H-index is 34 with more than 3800 citations and i10 index of 69 (Scopus). His research interests have been: a) MYC oncogene roles in cell cycle regulation and interactions with p53 and p27; b) MYC oncogene in chronic lymphocytic and chronic myeloid leukemia; and c) Roles of MYC and MNT oncogenes in lymphoma, which is the most active current area of research.

J. León teaches in the courses ““Molecular Biology of the Cell” and "Biology of Cancer" of Medicine and Biomedical Sciences degrees, as well as the Master of Molecular Biology and Biomedicine. He is a correspondent member of the Real Academia Nacional de Farmacia. He has co-authored a textbook (“Manual de Genética Molecular”, Ed. Síntesis) and filed three patents. He has served as Head of the Department of Molecular Biology, Director of the IBBTEC and Vice-Chancellor for Research of the UC. He has also served in evaluation panels of Spanish Plan Estatal, Cancer Research-UK and national research agencies of several countries.

 javier.leon@unican.es

 Pabellón de Gobierno. Avda. de los Castros, 54. 39005 Santander

Catedrático de Universidad

Doctor en Farmacia

 Control Transcripcional Del Cáncer Y Regulación De La División Celular

 INST. DE BIOMEDICINA Y BIOTECNOLOGÍA DE CANTABRIA

Specialty areas: BIOQUIMICA Y BIOLOGIA MOLECULAR

Identifiers

Other names in publications
  • Leoń, Javier
  • Léon, Javier
  • León, J.
  • León, Javier
  • Leon, Javier
  • Leon, J.
34 results 
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MYC directly transactivates CR2/CD21, the receptor of the Epstein-Barr virus, enhancing the viral infection of Burkitt lymphoma cells

Article

Oncogene, 2023, 42(45), 3358-3370

 Authorship: ESTER MOLINA HOYO, LUCIA GARCIA GUTIERREZ, VANESSA JUNCO RUISÁNCHEZ, MERCEDES PÉREZ-OLIVARES, VIRGINA G. DE YÉBENES, ROSA FERNANDA BLANCO FERNÁNDEZ, LAURA QUEVEDO PALACIO, JUAN CARLOS ACOSTA COBACHO, ANA V. MARÍN, DANIELA ULGIATI, RAMON MERINO PEREZ, MARIA DOLORES DELGADO VILLAR, IGNACIO VARELA EGOCHEAGA, JOSÉ R. REGUEIRO, IGNACIO MORENO DE ALBORAN, ALMUDENA R. RAMIRO, JAVIER LEON SERRANO

 2023

JKST6, a novel multikinase modulator of the BCR-ABL1/STAT5 signaling pathway that potentiates direct BCR-ABL1 inhibition and overcomes imatinib resistance in chronic myelogenous leukemia

Article

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie, 2021, 144, 112330

 Authorship: HAIDÉE ARANDA-TAVÍO, CARLOTA RECIO, PEDRO MARTÍN-ACOSTA, MIGUEL GUERRA-RODRÍGUEZ, YERAY BRITO-CASILLAS, ROSA FERNANDA BLANCO FERNÁNDEZ, VANESSA JUNCO RUISÁNCHEZ, JAVIER LEON SERRANO, JUAN CARLOS MONTERO, LUCÍA GANDULLO-SÁNCHEZ, GRANT MCNAUGHTON-SMITH, JUAN MANUEL ZAPATA, ATANASIO PANDIELLA, ÁNGEL AMESTY, ANA ESTÉVEZ-BRAUN, LEANDRO FERNÁNDEZ-PÉREZ, BORJA GUERRA

 01/12/2021

The multiple faces of MNT and its role as a MYC modulator

Article

Cancers, 2021, 13(18), 4682

 Authorship: JUDIT LIAÑO-PONS, MARIE ARSENIAN-HENRIKSSON, JAVIER LEON SERRANO

 2021

A novel role of MNT as a negative regulator of REL and the NF-kB pathway

Article

Oncogenesis, 2021, 10(1), 5 - (CORRECTION), 10(8), 57

 Authorship: JUDIT LIAÑO PONS, MARIA DEL CARMEN LAFITA NAVARRO, LORENA GARCIA GAIPO, CARLOTA COLOMER, JAVIER RODRÍGUEZ, ALEX VON KRIESGHEIM, PETER J HURLIN, FABIANA OURIQUE DA SILVA, MARIA DOLORES DELGADO VILLAR, ANNA BIGAS, ML ESPINOSA, JAVIER LEON SERRANO

 2021

The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells

Article

Journal of Biological Chemistry, 2020, 295(7), 2001-2017

 Authorship: MARIA DEL CARMEN LAFITA NAVARRO, JUDIT LIAÑO PONS, ANDREA QUINTANILLA CAVIA, IGNACIO VARELA EGOCHEAGA, ROSA FERNANDA BLANCO FERNÁNDEZ, FABIANA OURIQUE DA SILVA, GABRIEL BRETONES SANCHEZ, JULIA ARESTI, ESTER MOLINA HOYO, PATRICK CARROLL, PETER HURLIN, OCTAVIO A. ROMERO, MONTSE SÁNCHEZ-CÉSPEDES, ROBERT N. EISENMAN, MARIA DOLORES DELGADO VILLAR, JAVIER LEON SERRANO

 09/01/2020

Suppression of BCL6 function by HDAC inhibitor mediated acetylation and chromatin modification enhances BET inhibitor effects in B-cell lymphoma cells

Article

Scientific Reports, 2019, 9(1), 16495

 Authorship: MARIA GABRIELA CORTIGUERA RUIZ, LORENA GARCIA GAIPO, SIMON D. WAGNER, JAVIER LEON SERRANO, MARIA ANA BATLLE LOPEZ, MARIA DOLORES DELGADO VILLAR

 2019

Myc Stimulates Cell Cycle Progression Through the Activation of Cdk1 and Phosphorylation of p27

Article

Sci Rep , 9 (1), 18693

 Authorship: LUCIA GARCIA GUTIERREZ, GABRIEL BRETONES SANCHEZ, ESTER MOLINA HOYO, IGNACIO MARIA ARECHAGA ITURREGUI, CATHERINE SYMONDS, JUAN C. ACOSTA, ROSA FERNANDA BLANCO FERNÁNDEZ, ADRIÁN FERNÁNDEZ, LETICIA ALONSO, PIOTR SICINSKI, MARIANO BARBACID, DAVID SANTAMARÍA, JAVIER LEON SERRANO

 2019

The MYC antagonist MNT beyond MAX interaction

Conference object

ESMO Open 2018;3(Suppl 2):A157

 Authorship: MARIA DEL CARMEN LAFITA NAVARRO, JUDIT LIAÑO PONS, IGNACIO VARELA EGOCHEAGA, ROSA FERNANDA BLANCO FERNÁNDEZ, J. ARESTI, P. CARROLL, P.J. HURLIN, R.N. EISENMAN, MARIA DOLORES DELGADO VILLAR, JAVIER LEON SERRANO

 2018

ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA

Article

Oncogene, 2017, 36(12), 1733-1744

 Authorship: ANA TALAMILLO CANCELO, LARA GRANDE GONZALEZ, PATRICIA RUIZ ONTAÑÓN, CARLOS JOSE VELASQUEZ RODRIGUEZ, PILAR MOLLINEDO, SILVIA TORICES DEL VAL, PILAR SÁNCHEZ GÓMEZ, ÁNGELA AZNAR, AZUCENA ESPARIS OGANDO, CARLOS LÓPEZ LÓPEZ, MARIA DEL CARMEN LAFITA NAVARRO, MARIA TERESA BERCIANO BLANCO, JUAN ANTONIO MONTERO SIMON, ALFONSO VAZQUEZ BARQUERO, VÍCTOR SEGURA, NURIA T. VILLAGRA, ATANASIO PANDIELLA, MIGUEL ANGEL LAFARGA COSCOJUELA, JAVIER LEON SERRANO, JOSÉ A. MARTÍNEZ CLIMENT, VICTORIA SANZ MORENO, JOSE LUIS FERNANDEZ LUNA

 23/03/2017

CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia

Article

Oncotarget, 2017, 8(18), 29679-29698 - (CORRECTION), 2018, 9(63), 32272

 Authorship: BORJA GUERRA, PATRICIA MARTÍN RODRÍGUEZ, JUAN CARLOS DÍAZ CHICO, GRANT MCNAUGHTON-SMITH, SANDRA JIMÉNEZ ALONSO, IDAIRA HUESO FALCÓN, JUAN CARLOS MONTERO, RAQUEL BLANCO LANG, JAVIER LEON SERRANO, GERMÁN RODRÍGUEZ GONZÁLEZ, ANA ESTÉVEZ BRAUN, ATANASIO PANDIELLA, BONIFACIO NICOLÁS DÍAZ CHICO, LEANDRO FERNÁNDEZ PÉREZ

 2017

The expression of MNT, a MYC antagonist, is autoregulated at the mRNA and protein level

Conference object

European Journal of Cancer, Vol. 61, Suppl. 1 (2016) S21-S22

 Authorship: MARIA DEL CARMEN LAFITA NAVARRO, JUDIT LIAÑO PONS, FABIANA OURIQUE DA SILVA, J. ARESTI, P.J. HURLIN, JAVIER LEON SERRANO

 2016

Myc-dependent cell cycle progression through the activation of CDK1 and phosphorylation of p27

Conference object

European Journal of Cancer, Vol. 61, Suppl. 1 (2016) S78

 Authorship: LUCIA GARCIA GUTIERREZ, GABRIEL BRETONES SANCHEZ, IGNACIO MARIA ARECHAGA ITURREGUI, D. SANTAMARÍA, M. BARBACID, JAVIER LEON SERRANO

 2016

NUMB inactivation confers resistance to imatinib in chronic myeloid leukemia cells

Article

Cancer Letters, 2016, 375(1), 92-99

 Authorship: EVA GARCIA ALEGRIA, MARIA DEL CARMEN LAFITA NAVARRO, R. AGUADO, LUCIA GARCIA GUTIERREZ, KYLE SARNATARO, C. RUIZ HERGUIDO, F. MARTÍN, ANNA BIGAS, M. CANELLES, JAVIER LEON SERRANO

 2016

MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis

Article

Oncotarget, 2016, 7(43), 69536-69548

 Authorship: MARIA DEL CARMEN LAFITA NAVARRO, ROSA FERNANDA BLANCO FERNÁNDEZ, JORGE MATA GARRIDO, JUDIT LIAÑO PONS, OLGA TAPIA MARTINEZ, LUCIA GARCIA GUTIERREZ, EVA GARCIA ALEGRIA, MARIA TERESA BERCIANO BLANCO, MIGUEL ANGEL LAFARGA COSCOJUELA, JAVIER LEON SERRANO

 2016

El inhibidor de histonas deacetilasa romidepsina induce diferenciación en linfomas de origen centrogerminal a través de la regulación de BCL6

Conference object

Haematologica Oct. 2016 Vol.101 s4: 205-206

 Authorship: MARIA ANA BATLLE LOPEZ, MARIA GABRIELA CORTIGUERA RUIZ, LORENA GARCIA GAIPO, INSUNZA ANDRÉS, MARIA DE LAS MERCEDES COLORADO ARAUJO, JAVIER LEON SERRANO, MARIA DOLORES DELGADO VILLAR

 01/10/2016

MYC as therapeutic target in leukemia and lymphoma

Article

Blood and Lymphatic Cancer: Targets and Therapy, 2015, 5, 75-91

 Authorship: MARIA GABRIELA CORTIGUERA RUIZ, MARIA ANA BATLLE LOPEZ, MARTA ALBAJAR MOLERA, MARIA DOLORES DELGADO VILLAR, JAVIER LEON SERRANO

 2015

Myc and cell cycle control

Article

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 2015, 1849(5), 506-16

 Authorship: GABRIEL BRETONES SANCHEZ, MARIA DOLORES DELGADO VILLAR, JAVIER LEON SERRANO

 2015

CD3e recruits Numb to promote TCR degradation

Article

International Immunology, 2016, 28(3), 127-137

 Authorship: NADIA MARTÍN BLANCO, DANIEL JIMÉNEZ TEJA, GABRIEL BRETONES SANCHEZ, ALDO BORROTO, MICHAEL CARABALLO, ISABELLA SCREPANTI, JAVIER LEON SERRANO, BALBINO ALARCÓN, MATILDE CANELLES

 2015

A novel mutation in ADAMTS13 of a child with Upshaw-Schulman Syndrome

Article

Thrombosis and Haemostasis, 2014, 112(5), 1065-1068

 Authorship: A PÉREZ RODRÍGUEZ, MARIA ANA BATLLE LOPEZ, ROSA FERNANDA BLANCO FERNÁNDEZ, IGNACIO VARELA EGOCHEAGA, JAVIER LEON SERRANO, MARIA DOLORES DELGADO VILLAR, ESTHER LOURÉS, ÁNGELA RODRÍGUEZ TRILLO, ARÁNZAZU GARCÍA RIVERO, JOANA COSTA PINTO, JAVIER BATLLE, MARÍA FERNANDA LÓPEZ FERNÁNDEZ

 01/11/2014

High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle

Article

Oncotarget. 2014, 5(13), 4694-708

 Authorship: JUAN MANUEL CARABALLO OTERO, JUAN CARLOS ACOSTA COBACHO, MIGUEL ANGEL CORTES VAZQUEZ, MARTA ALBAJAR MOLERA, MARIA TERESA GOMEZ CASARES, MARIA ANA BATLLE LOPEZ, MARIA ANGELES CUADRADO DEL BARRIO, ARANTZA ONAINDIA PEREZ, GABRIEL BRETONES SANCHEZ, FRANCISCO JAVIER LLORCA DIAZ, MIGUEL ANGEL PIRIS PINILLA, DOLORES COLOMER PUJOL, JAVIER LEON SERRANO

 15/07/2014

Sin3b interacts with Myc and decreases Myc levels

Article

Journal of Biological Chemistry, 2014, 289(32), 22221-36

 Authorship: PABLO GARCIA SANZ, ANDREA QUINTANILLA CAVIA, MARIA DEL CARMEN LAFITA NAVARRO, GEMA MORENO BUENO, LUCIA GARCIA GUTIERREZ, VEDRANA TABOR, IGNACIO VARELA EGOCHEAGA, YUZURU SHIIO, LARS-GUNNAR LARSSON, FRANCISCO PORTILLO, JAVIER LEON SERRANO

 08/08/2014

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