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 Detalle Proyecto

DESCIFRANDO EL MECANISMO MOLECULAR DE LAS SINTASAS DE ACIDOS GRASOS POLIINSATURADOS (PGC2018-093885-B-I00) (MCI/AEI/FEDER,UE)

Consumption of polyunsaturated fatty acids (PUFA) is directly related with the reduction of cancer development, inflammatory processes and allergies. PUFA also protect both the cardiovascular and the nervous systems. The nutraceutical importance of PUFAs in human and animal feeding makes them molecules with a high added value. Thus, from a biotechnological point of view it is interesting the existence of some microorganisms able to produce high amounts of PUFA (EPA or DHA) thanks to a specific enzymatic complex called Pfa synthase. These proteins are highly homologous with enzymatic domains involved in the synthesis of conventional saturated fatty acids with a modular organization similar to type I fatty acid synthases (FAS) and bacterial polyketide synthases (PKS). In this project we will analysed these Pfa proteins involved in PUFA synthesis in marine bacteria, myxobacteria and other microorganisms (WP1). The structure and function of these PUFA synthases or their domains will be studied. At the same time, we will optimize PUFA production by modification of the producer strain or optimization of PUFA synthases by protein engineering (WP2). By rational design or directed evolution we will be able to modify these proteins involved in PUFA synthesis to enhance their activity or change their substrate or product specificity. To sum it up, this project will allow the detailed knowledge of the molecular mechanisms of PUFA synthases. This way, we will also obtain information of the different modifications we can do to improve PUFA production or even produce novel PUFA or other chemical commodities.

Entidades financiadoras y/o coordinador

  • AGENCIA ESTATAL DE INVESTIGACION

Tipología: Proyectos competitivos nacionales publicos

 Fecha de inicio: 01/01/2019

 Fecha de fin: 31/12/2021

Financiación: 105.875 

Entidad gestora: UNIVERSIDAD DE CANTABRIA

Responsable: GABRIEL MONCALIAN MONTES

Equipo de investigación

ADRIAN ALONSO NUÑEZ