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Biologic therapy in severe and refractory peripheral ulcerative keratitis (PUK). Multicenter study of 34 patients

Abstract: Purpose: We assessed the efficacy and safety of biologic therapy in severe and refractory Peripheral Ulcerative Keratitis (PUK). Design: Open-label multicenter study of biologic-treated patients with severe PUK refractory to conventional immunosuppressive drugs. Subjects: We studied 34 patients (44 affected eyes) (24 women/10 men; mean age, 55.26§17.4 years). PUK was associated with a well-defined condition in 29 of them (rheumatoid arthritis [n = 20], psoriatic arthritis [n = 2], inflammatory bowel disease [n = 2], Beh¸cet disease [n = 1], granulomatosis with polyangiitis [n = 1], microscopic polyangiitis [n = 1], systemic lupus erythematosus [n = 1] and axial spondyloarthritis [n = 1]). Besides topical and oral systemic glucocorticoids, patients had received: methylprednisolone pulses [n = 9], and conventional immunosuppressive drugs, mainly methotrexate [n = 18], and leflunomide [n = 7]. Eleven patients had required ocular surgery prior to biologic therapy. Methods: Following biologic therapy, baseline main outcomes were compared with those found at 1st week, 1st and 6th months and 1st year. Main outcome measures: Efficacy and safety of biologic therapy. Efficacy was analyzed by the assessment of corneal inflammation (corneal thinning, central keratolysis and ocular perforation); other causes of ocular surface inflammation (scleritis, episcleritis); intraocular inflammation (uveitis); visual acuity and glucocorticoid sparing effect. Results: The first biologic agents used were anti-TNFa drugs (n = 25); adalimumab (n = 16), infliximab (n = 8), etanercept (n = 1), and non-TNFa agents (n = 9); rituximab (n = 7), tocilizumab (n = 1) belimumab (n = 1) and abatacept (n = 1). During the follow-up, switching to a second biologic agent was required in 12 of the 25 (48%) patients treated with anti-TNFa drugs. However, no switching was required in those undergoing biologic therapy different from anti-TNFa agents. The main outcome variables showed a rapid and maintained improvement after a mean follow-up of 23.7 § 20 months. Major adverse effects were tachyphylaxis, relapsing respiratory infections, supraventricular tachycardia, pulmonary tuberculosis and death, one each.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Seminars in Arthritis and Rheumatism 50 (2020) 608-615

Editorial: Elsevier

 Año de publicación: 2020

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.semarthrit.2020.03.023

ISSN: 0049-0172,1532-866X

Url de la publicación: https://doi.org/10.1016/j.semarthrit.2020.03.023

Autores/as

LUCIA C. DOMINGUEZ-CASAS

LARA SÁNCHEZ-BILBAO

VANESA CALVO-RÍO

OLGA MAÍZ

ANA BLANCO

EMMA BELTRÁN

LUCÍA MARTÍNEZ-COSTA

ROSALÍA DEMETRÍO-PABLO

MARÍA ÁLVAREZ DEL BUERGO

ESTEBAN RUBIO-ROMERO

DAVID DÍAZ-VALLE

RUTH LOPEZ-GONZALEZ

ANGEL M. GARCÍA-APARICIO

ANTONIO J. MAS

NURIA VEGAS-REVENGA

SANTOS CASTAÑEDA

RICARDO BLANCO ALONSO