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 Detalle_Publicacion

Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models

Abstract: Background: In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Secondly, we also evaluated the performance of risk age models in subgroups based on RA disease characteristics. Methods: RA patients aged 30?70 years were included from an international consortium named A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA). Prior CVD and diabetes mellitus were exclusión criteria. The discriminatory ability of specific risk age models was evaluated using c-statistics and their standard errors after calculating time until fatal or non-fatal CVD or last follow-up. Results: A total of 1974 patients were included in the main analyses, and 144 events were observed during followup, the median follow-up being 5.0 years. The risk age models gave highly correlated results, demonstrating R2 values ranging from 0.87 to 0.97. However, risk age estimations differed > 5 years in 15?32% of patients. C-statistics ranged 0.68?0.72 with standard errors of approximately 0.03. Despite certain RA characteristics being associated with low c-indices, standard errors were high. Restricting analysis to European RA patients yielded similar results. Conclusions: The cardiovascular risk age and vascular age models have comparable performance in predicting CVD in RA patients. The influence of RA disease characteristics on the predictive ability of these prediction models remains inconclusive.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Arthritis Research & Therapy (2020) (2020) 22:90

Editorial: BioMed Central

 Año de publicación: 2020

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.1186/s13075-020-02178-z

ISSN: 1478-6354

Url de la publicación: https://doi.org/10.1186/s13075-020-02178-z

Autores/as

GRUNDE WIBETOE

JOSEPH SEXTON

EIRIK IKDAHL

SILVIA ROLLEFSTAD

GEORGE D. KITAS

PIET VAN RIEL

SHERINE GABRIEL

TORE K. KVIEN

KAREN DOUGLAS

AAMER SANDOO

ELKE E. ARTS

SOLVEIG WÅLLBERG-JONSSON

SOLBRITT RANTAPÄÄ DAHLQVIST

GEORGE KARPOUZAS

PATRICK H. DESSEIN

LINDA TSANG

HANI EL-GABALAWY

CAROL A. HITCHON

VIRGINIA PASCUAL-RAMOS