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Incidence of first cardiovascular event in spanish patients with chronic inflammatory rheumatic diseases: prospective data from the carma project after 5 years of follow-up

Abstract: Objectives: To determine the incidence and risk factors implicated in the development of first cardiovascular (CV) event (CVE) in patients with chronic inflammatory rheumatic diseases (CIRD) attending Spanish rheumatology clinics after 5 years of follow-up Methods: Analysis of data of patients included in an observational prospective study [CARdiovascular in rheuMAtology (CARMA) project] after 5 years of follow-up. The study includes a cohort of 2234 patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA), and another cohort of matched individuals (n=677) without CIRD from 67 hospitals in Spain. Cumulative incidence per 1000 patients of CVE was estimated in both cohorts at 5 years from the start. Weibull proportional hazard model was used to calculate the Hazard Ratio (HR) and 95% confidence intervals (CI) of the risk factors involved in the development of CV events. Losses to follow-up and their causes were also analyzed. Results: The total number patient who completed the follow-up visit at 5 years was 2.382 (81.9%). Fifteen patients died due to CVE and sixty due to non-CVE. The patients with CIRD showed higher cardiovascular cumulative incidence (40.5; 95% CI: 36.2-44.8) than controls (28.3; 95% CI: 21.8-34.8). The higher risk of developing a first CVE during the 5 years of follow-up was seen in patients with AS (HR: 4.60; 95% CI: 1.32-15.99; p=0.02), those with older age (HR:1.09; 95% CI: 1.05-1.13; p<0.001), higher systolic blood pressure (HR: 2.64; 95% CI: 1.32-5.25; p=0.006), and those with longer duration of the rheumatic disease (HR: 1.07; 95% CI: 1.03-1.12; p=0.002). In contrast, woman gender was a protective factor (HR: 0.45; 95% CI: 0.21-0.99; p=0.047). Conclusion: Patients with AS prospectively followed-up at rheumatology outpatient clinics showed higher risk of developing a first CVE than those without CIRD. Besides traditional CV disease risk factors, a longer time course of the disease is a risk factor for the development of CV disease in patients with CIRD.

Otras comunicaciones del congreso o articulos relacionados con autores/as de la Universidad de Cantabria

 Congreso: Annual European Congress of Rheumatology (EULAR) (2020)

Editorial: BMJ Publishing Group

 Año de publicación: 2020

Nº de páginas: 1

Tipo de publicación: Comunicación a Congreso

 DOI: 10.1136/annrheumdis-2020-eular.4711

ISSN: 0003-4967,1468-2060

Url de la publicación: http://dx.doi.org/10.1136/annrheumdis-2020-eular.4711

Autores/as

MARTIN-MARTINEZ, M. A.

CASTAÑEDA, S.

SÁNCHEZ-ALONSO, F.

GARCÍA GOMEZ, C.

GONZALEZ JUANATEY, C.

BELMONTE, M.A.

TORNERO, J.

SANTOS REY, J.

SANCHEZ GONZALEZ, C.O.

QUESADA-MASACHS, E.

MORENO GIL, M.D.

COBO-IBÁÑEZ, I.

PINTO TASENDE, J.A.

BABÍO, J.

BONILLA, G.

MAS, A.J.

MANERO, J.

ROMERA, M.