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A predominant involvement of the triple seropositive patients and others with rheumatoid factor in the association of smoking with rheumatoid arthritis

Abstract: The major environmental risk factor for rheumatoid arthritis (RA) is smoking, which according to a widely accepted model induces protein citrullination in the lungs, triggering the production of anticitrullinated protein antibodies (ACPA) and RA development. Nevertheless, some research findings do not fit this model. Therefore, we obtained six independent cohorts with 2253 RA patients for a detailed analysis of the association between smoking and RA autoantibodies. Our results showed a predominant association of smoking with the concurrent presence of the three antibodies: rheumatoid factor (RF), ACPA and anti-carbamylated protein antibodies (ACarPA) (3 Ab vs. 0 Ab: OR = 1.99, p = 2.5 × 10?8). Meta-analysis with previous data (4491 patients) confirmed the predominant association with the concurrent presence of the three antibodies (3 Ab vs. 0 Ab: OR = 2.00, p = 4.4 ×10?16) and revealed that smoking was exclusively associated with the presence of RF in patients with one or two antibodies (RF+ 1+2 vs. RF? 0+1+2: OR = 1.32, p = 0.0002). In contrast, no specific association with ACPA or ACarPA was found. Therefore, these results showed the need to understand how smoking favors the concordance of RA specific antibodies and RF triggering, perhaps involving smoking-induced epitope spreading and other hypothesized mechanisms.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Scientific Reports (2020)10:3355

Editorial: Nature Publishing Group

 Año de publicación: 2020

Nº de páginas: 11

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/s41598-020-60305-x

ISSN: 2045-2322

Url de la publicación: https://doi.org/10.1038/s41598-020-60305-x

Autores/as

CRISTINA REGUEIRO

LUIS RODRIGUEZ-RODRIGUEZ

RAQUEL LOPEZ-MEJIAS

LAURA NUÑO

ANA TRIGUERO-MARTINEZ

EVA PEREZ-PAMPIN

ALFONSO CORRALES

ALEJANDRO VILLALBA

YOLANDA LOPEZ-GOLAN

LYDIA ABASOLO

SARA REMUZGO-MARTÍNEZ

ANA M. ORTIZ

EVA HERRANZ

ANA MARTÍNEZ-FEITO

CARMEN CONDE

ANTONIO MERA-VARELA

ALEJANDRO BALSA

ISIDORO GONZALEZ-ALVARO

BENJAMÍN FERNANDEZ-GUTIERREZ