Buscar

Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

Dietary Constituents: Relationship with Breast Cancer Prognostic (MCC-SPAIN Follow-Up)

Abstract: The aim of this study was to characterize the relationship between the intake of the major nutrients and prognosis in breast cancer. A cohort based on 1350 women with invasive (stage I-IV) breast cancer (BC) was followed up. Information about their dietary habits before diagnosis was collected using a semi-quantitative Food Frequency Questionnaire. Participants without FFQ or with implausible energy intake were excluded. The total amount consumed of each nutrient (Kcal/day) was divided into tertiles, considering as "high intakes" those above third tertile. The main effect studied was overall survival. Cox regression was used to assess the association between death and nutrient intake. During a median follow-up of 6.5 years, 171 deaths were observed. None of the nutrients analysed was associated with mortality in the whole sample. However, in normal-weight women (BMI 18.5-25 kg/m2) a high intake of carbohydrates (?809 Kcal/day), specifically monosaccharides (?468 Kcal/day), worsened prognostic compared to lowest (?352 Kcal/day). Hazard Ratios (HRs) for increasing tertiles of intake were HR:2.22 95% CI (1.04 to 4.72) and HR:2.59 95% CI (1.04 to 6.48), respectively (p trend = 0.04)). Conversely, high intakes of polyunsaturated fats (?135 Kcal/day) improved global survival (HR: 0.39 95% CI (0.15 to 1.02) p-trend = 0.05) compared to the lowest (?92.8 kcal/day). In addition, a protective effect was found substituting 100 kcal of carbohydrates with 100 kcal of fats in normal-weight women (HR: 0.76 95% CI (0.59 to 0.98)). Likewise, in premenopausal women a high intake of fats (?811 Kcal/day) showed a protective effect (HR:0.20 95% CI (0.04 to 0.98) p trend = 0.06). Finally, in Estrogen Receptors (ER) negative tumors, we found a protective effect of high intake of animal proteins (?238 Kcal/day, HR: 0.24 95% CI (0.06 to 0.98). According to our results, menopausal status, BMI and ER status could play a role in the relationship between diet and BC survival and must be taken into account when studying the influence of different nutrients.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Int J Environ Res Public Health . 2020 Dec 24;18(1):84.

Editorial: MDPI

 Año de publicación: 2020

Nº de páginas: 17

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/ijerph18010084

ISSN: 1661-7827,1660-4601

Url de la publicación: https://doi.org/10.3390/ijerph18010084

Autores/as

GUTIÉRREZ RUIZ, NURIA

ARAGONÉS, NURIA

AMIANO, PILAR

MOLINA DE LA TORRE, ANTONIO JOSÉ

GUEVARA, MARCELA

OBON SANTACANA, MIREIA

FERNÁNDEZ TARDÓN, GUILLERMO

MOLINA BARCELÓ, ANA

ALGUACIL, JUAN

MARCOS GRAGERA, RAFAEL

MARIA PAZ RODRIGUEZ CUNDIN

CASTAÑO VINYALS, GEMMA

CANSECO FERNÁNDEZ, ROSARIO

CASTILLA, JESÚS

MOLINUEVO, AMAIA

PÉREZ GÓMEZ, BEATRIZ

KOGEVINAS, MANOLIS