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Impaired HDL cholesterol efflux capacity in systemic lupus erythematosus patients is related to subclinical carotid atherosclerosis

Abstract: Objectives. Lipid profiles appear to be altered in SLE patients due to disease activity and inflammation. Cholesterol efflux capacity (CEC) is the ability of high-density lipoprotein cholesterol to accept cholesterol from macrophages. CEC has been linked to cardiovascular events in the general population and is impaired in SLE patients. The aim of this study was to establish whether CEC is related to subclinical carotid atherosclerosis in SLE patients. Methods. The present report is of a cross-sectional study that encompassed 418 individuals: 195 SLE patients and 223 controls. CEC, using an in vitro assay, and lipoprotein serum concentrations were assessed in patients and controls. Carotid intima-media thickness and carotid plaques were evaluated in SLE patients. A multivariable analysis was performed to study the relationship of CEC to SLE-related data, lipid profile and subclinical carotid atherosclerosis. Results. CEC was downregulated in SLE patients [8.1 (4.2) % vs 16.9 (10.4) %, P ¼ 0.004). This occurred independently of traditional cardiovascular risk factors, statin use or other variations in the lipid profile related to the disease. Traditional cardiovascular risk factors, both in patients and controls, and SLE-related data such as activity, severity or damage were not associated with CEC. After multivariable regression analysis including lipid profile? related molecules, CEC was inversely and independently associated with the presence of carotid plaques in SLE patients [odds ratio 0.87 (95% CI: 0.78, 0.97), P ¼ 0.014]. Conclusion. CEC is impaired in SLE patients independently of other inflammation-related lipid profile modifications that occur during the disease. CEC is associated with carotid plaques in SLE patients

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Rheumatology 2020;59:2847-2856

Editorial: Oxford University Press

 Año de publicación: 2020

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.1093/rheumatology/keaa038

ISSN: 1462-0324,1462-0332

Url de la publicación: https://doi.org/10.1093/rheumatology/keaa038

Autores/as

HIURMA SÁNCHEZ-PÉREZ

JUAN CARLOS QUEVEDO-ABELEDOL

LAURA DE ARMAS-RILLO

ÍÑIGO RUA--FIGUEROA

BEATRIZ TEJERA-SEGURA

ESTEFANÍA ARMAS-GONZÁLEZ

JOSÉ DAVID MACHADO

JOSE A GARCÍA-DOPICO

ALEJANDRO JIMENEZ-SOSA

CARLOS RODRÍGUEZ--LOZANO

FEDERICO DÍAZ-GONZÁLEZ

IVÁN FERRAZ-AMARO