Abstract: Fatigue is one of the main forms of deterioration in asphalt mixtures, endangering their service life due to the progressive appearance and expansion of cracks. A sustainable approach to increase the lifetime of asphalt pavement has been found in self-healing technology, especially if boosted with metal by-products due to their economic and environmental interest. Under these circumstances, this research addressed the fatigue behavior of self-healing asphalt mixtures including industrial sand blasting by-products obtained from sieving and aspiration processes. Hence, a uniaxial fatigue test was carried out to determine whether these experimental mixtures can provide a similar response to that of a reference asphalt concrete (AC-16). This analysis was undertaken with the support of descriptive and inferential statistics, whose application proved the absence of significant differences in the fatigue performance of self-healing experimental mixtures with respect to conventional asphalt concrete. These results suggest that designing self-healing mixtures with metal by-products is a sustainable approach to increase the lifetime of asphalt pavements, while contributing to the circular economy through diverse economic and environmental benefits.