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Pretransplant CMV-Specific T-Cell Immunity But Not Dose of Antithymocyte Globulin Is Associated With Recovery of Specific Immunity After Kidney Transplantation

Abstract: Background: This is a prospective, multicenter, observational study in cytomegalovirus (CMV)-seropositive kidney transplant recipients with pretransplant CMV-specific cell-mediated immunity (CMV-CMI) receiving antithymocyte globulin (ATG). We aimed to investigate posttransplant CMV-CMI over time and the impact of the dose-dependent ATG. Methods: CMV-CMI was assessed at days +30, +45, +60, and +90 after transplantation with the QuantiFERON-CMV assay. A reactive result (interferon-? [IFN-?] ? 0.2 IU/mL) indicated a positive CMV-CMI. Results: A total of 78 positive CMV-CMI patients were enrolled in the study, of which 59.5% had a positive CMV-CMI at day +30 and 82.7% at day +90. Multivariate logistic regression analysis showed that ATG dose was not associated with positive CMV-CMI at any point. However, pretransplant IFN-? level (>12 IU/mL vs ?12 IU/mL) was associated with positive CMV-CMI at day +30 (odds ratio, 12.9; 95% confidence interval, 3.1-53.3; P < .001). In addition, all the patients who did not recover CMV-CMI at day +90 had a pretransplant IFN-? level ?12 IU/mL. Conclusions: More than half of CMV-seropositive kidney transplant recipients receiving ATG recover (or maintain) CMV-CMI by the first month after transplantation. The pretransplant IFN-? level, but not the ATG dose, shows a strong association with the kinetics of this recovery.

 Fuente: J Infect Dis . 2021 Apr 8;223(7):1205-1213

Editorial: Oxford University Press

 Año de publicación: 2020

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1093/infdis/jiaa503

ISSN: 0022-1899,1537-6613

Url de la publicación: https://doi.org/10.1093/infdis/jiaa503

Autores/as

PÁEZ VEGA, AURORA

CANTISÁN, SARA

AGÜERA, MARIA L.

SUÑER, MARTA

FACUNDO, CARMEN

YUSTE, JOSE R.

FERNÁNDEZ RUIZ, MARIO

MONTEJO, MIGUEL

REDONDO PACHÓN, DOLORES

LÓPEZ OLIVA, MARÍA O.

FERNÁNDEZ RODRÍGUEZ, ANA

HERNÁNDEZ, DOMINGO

LEN, ÓSCAR

MUÑOZ, PATRICIA

VALLE ARROYO, JORGE

RODELO HAAD, CRISTIAN

CORDERO, ELISA

TORRE CISNEROS, ELISA