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 Detalle_Publicacion

Amyotrophic lateral sclerosis (ALS), cancer, autoimmunity and metabolic disorders: An unsolved tantalizing challenge

Abstract: Amyotrophic lateral sclerosis (ALS) commonly referred to as motor neurone disease, is a neurodegenerative disease of unknown pathogenesis that progresses rapidly and has attracted an increased amount of scholarly interest in recent years. The current conception of amyotrophic lateral sclerosis has transitioned into a more complex theory in which individual genetic risk, ageing and environmental factors interact, leading to disease onset in subjects in whom the sum of these factors reach a determined threshold. Based on this conceptualization, the environmental conditions, particularly those that are potentially modifiable, are becoming increasingly relevant. In this review, the current integrative model of the disease is discussed. In addition, we explore the role of cancer, autoimmunity and metabolic diseases as examples of novel, non-genetic and environmental factors. Together with the potential triggers or perpetuating pathogenic mechanisms along with new insights into potential lines of future research are provided. LINKED ARTICLES: This article is part of a themed issue on Neurochemistry in Japan. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.6/issuetoc.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Br J Pharmacol . 2021 Mar;178(6):1269-1278

Editorial: Wiley

 Año de publicación: 2021

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.1111/bph.15151

ISSN: 0007-1188,1476-5381

Url de la publicación: https://doi.org/10.1111/bph.15151

Autores/as

JAVIER RIANCHO ZARRABEITIA

MANUEL DELGADO ALVARADO

MARIA DOLORES ANDREU GOSALBEZ

PAZ FAJARDO, LUCÍA

AROZAMENA, SARA

GIL BEA, FRANCISCO JAVIER

LÓPEZ DE MUNAÍN, ADOLFO