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 Detalle_Publicacion

Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients

Abstract: Introduction: Our goal was to study whether influenza vaccination induced antibody mediated rejection in a large cohort of solid organ transplant recipients (SOTR). Methods: Serum anti-Human Leukocyte Antigen (HLA) antibodies were determined using class I and class II antibody-coated latex beads (FlowPRATM Screening Test) by flow cytometry. Anti-HLA antibody specificity was determined using the single-antigen bead flow cytometry (SAFC) assay and assignation of donor specific antibodies (DSA) was performed by virtual-crossmatch. Results: We studied a cohort of 490 SOTR that received an influenza vaccination from 2009 to 2013: 110 (22.4%) received the pandemic adjuvanted vaccine, 59 (12%) within the first 6 months post-transplantation, 185 (37.7%) more than 6 months after transplantation and 136 (27.7%) received two vaccination doses. Overall, no differences of anti-HLA antibodies were found after immunization in patients that received the adjuvanted vaccine, within the first 6 months post-transplantation, or based on the type of organ transplanted. However, the second immunization dose increased the percentage of patients positive for anti-HLA class I significantly compared with patients with one dose (14.6% vs. 3.8%; P = 0.003). Patients with pre-existing antibodies before vaccination (15.7% for anti-HLA class I and 15.9% for class II) did not increase reactivity after immunization. A group of 75 (14.4%) patients developed de novo anti-HLA antibodies, however, only 5 (1.02%) of them were DSA, and none experienced allograft rejection. Only two (0.4%) patients were diagnosed with graft rejection with favorable outcomes and neither of them developed DSA. Conclusion: Our results suggest that influenza vaccination is not associated with graft rejection in this cohort of SOTR.

 Fuente: Front Immunol . 2020 Oct 6;11:1917

Editorial: Frontiers Research Foundation

 Año de publicación: 2020

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.3389/fimmu.2020.01917. eCollection 2020

ISSN: 1664-3224

Url de la publicación: https://doi.org/10.3389/fimmu.2020.01917

Autores/as

CORDERO, ELISA

BULNES RAMOS, ÁNGEL

AGUILAR GUISADO, MANUELA

GONZÁLEZ ESCRIBANO, FRANCISCA

OLIVAS, ISRAEL

TORRE CISNEROS, JULIÁN

GAVALDÁ, JOAN

AYDILLO, TERESA

MORENO, ASUNCIÓN

MONTEJO, MIGUEL

BLANES, MARINO

FORTÚN, JESÚS

SUÁREZ BENJUMEA, ALEJANDRO

LÓPEZ MEDRANO, FRANCISCO

ROCA, CRISTINA

LARA, ROSARIO

PÉREZ ROMERO, PILAR