Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

A Contemporary Picture of Enterococcal Endocarditis

Abstract: Background: Enterococcal endocarditis (EE) is a growing entity in Western countries. However, quality data from large studies is lacking. Objectives: The purpose of this study was to describe the characteristics and analyze the prognostic factors of EE in the GAMES cohort. Methods: This was a post hoc analysis of a prospectively collected cohort of patients from 35 Spanish centers from 2008 to 2016. Characteristics and outcomes of 516 cases of EE were compared with those of 3,308 cases of nonenterococcal endocarditis (NEE). Logistic regression and Cox proportional hazards regression analysis were performed to investigate risk factors for in-hospital and 1-year mortality, as well as relapses. Results: Patients with EE were significantly older; more frequently presented chronic lung disease, chronic heart failure, prior endocarditis, and degenerative valve disease; and had higher median age-adjusted Charlson score. EE more frequently involved the aortic valve and prosthesis (64.3% vs. 46.7%; p < 0.001; and 35.9% vs. 28.9%; p = 0.002, respectively) but less frequently pacemakers/defibrillators (1.5% vs. 10.5%; p < 0.001), and showed higher rates of acute heart failure (45% vs. 38.3%; p = 0.005). Cardiac surgery was less frequently performed in EE (40.7% vs. 45.9%; p = 0.024). No differences in in-hospital and 1-year mortality were found, whereas relapses were significantly higher in EE (3.5% vs. 1.7%; p = 0.035). Increasing Charlson score, LogEuroSCORE, acute heart failure, septic shock, and paravalvular complications were risk factors for mortality, whereas prior endocarditis was protective and persistent bacteremia constituted the sole risk factor for relapse. Conclusions: Besides other baseline and clinical differences, EE more frequently affects prosthetic valves and less frequently pacemakers/defibrillators. EE presents higher rates of relapse than NEE. Trial registration: ClinicalTrials.gov NCT00871104.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: J Am Coll Cardiol . 2020 Feb 11;75(5):482-494

Editorial: Elsevier

 Año de publicación: 2020

Nº de páginas: 13

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.jacc.2019.11.047

ISSN: 0735-1097,1558-3597

Url de la publicación: https://doi.org/10.1016/j.jacc.2019.11.047

Autores/as

PERICÀS, JUAN M.

LLOPIS, JAUME

MUÑOZ, PATRICIA

GÁLVEZ ACEBAL, JUAN

KESTLER, MARTHA

VALERIO, MARICELA

HERNÁNDEZ MENESES, MARTA

GOENAGA, MIGUEL Á.

COBO BELAUSTEGUI, MANUEL

MONTEJO, MIGUEL

OJEDA BURGOS, GUILLERMO

SOUSA REGUEIRO, M. DOLORES

ALARCÓN, ARÍSTIDES DE

RAMOS MARTÍNEZ, ANTONIO

MIRÓ, JOSÉ M.

GAMES INVESTIGATORS