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Identification of vessel wall anomalies in thoracic aortic aneurysms through optical coherence tomography and gradient-based strategies

Abstract: Optical Coherence Tomography is a natural candidate for imaging biological structures just under tissue surface. Human thoracic aorta from aneurysms reveal elastin disorders and smooth muscle cell alterations when visualizing the media layer of the aortic wall, which is only some tens of microns in depth from surface. The resulting images require a suitable processing to enhance interesting disorder features and to use them as indicators for wall degradation, converting OCT into a hallmark for diagnosis of risk of aneurysm under intraoperative conditions. This work proposes gradient-based digital image processing approaches to conclude this risk. These techniques are believed to be useful in these applications as aortic wall disorders directly affect the refractive index of the tissue, having an effect on the gradient of the tissue reflectivity that conform the OCT image. Preliminary results show that the direction of the gradient contains information to estimate the tissue abnormality score. The detection of the edges of the OCT image is performed using the Canny algorithm. The edges delineate tissue disorders in the region of interest and isolate the abnormalities. These edges can be quantified to estimate a degradation score. Furthermore, the direction of the gradient seems to be a promising enhancement technique, as it detects areas of homogeneity in the region of interest. Automatic results from gradient-based strategies are finally compared to the histopathological global aortic score, which accounts for each risk factor presence and seriousness.

Otras comunicaciones del congreso o articulos relacionados con autores/as de la Universidad de Cantabria

 Autoría: Eguizabal A., Real E., Pontón A., Calvo Diez M., Val-Bernal J., Mayorga M., Revuelta J., López-Higuera J., Conde O.,

 Congreso: Biophotonics: Photonic Solutions for Better Health Care (4ª : 2014 : Bruselas)

Editorial: SPIE Society of Photo-Optical Instrumentation Engineers

 Año de publicación: 2014

Nº de páginas: 8

Tipo de publicación: Comunicación a Congreso

 DOI: 10.1117/12.2051397

ISSN: 0277-786X,1996-756X

Proyecto español: FIS2010-19860

Url de la publicación: https://doi.org/10.1117/12.2051397

Autores/as

ALMA EGUIZABAL AGUADO

EUSEBIO REAL PEÑA

ALEJANDRO PONTON CORTINA

MARTA CALVO DIEZ

JOSE FERNANDO VAL BERNAL

MARTA M. MAYORGA FERNANDEZ

JOSE MANUEL REVUELTA SOBA