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High Pretransplant BAFF Levels and B-cell Subset Polarized towards a Memory Phenotype as Predictive Biomarkers for Antibody-Mediated Rejection

Abstract: Antibody-mediated rejection (AbMR) is one of the leading causes of graft loss in kidney transplantation and B cells play an important role in the development of it. A B-cell activating factor (BAFF) is a cytokine involved in B cell ontogeny. Here, we analyzed whether B cell maturation and the e ect of B cell soluble factors, such as BAFF could be involved in AbMR. Serum BAFF levels and B and T cell subpopulations were analyzed 109 kidney transplant patients before transplantation and at 6 and 12 months after kidney transplantation. Pretransplant serum BAFF levels as well as memory B cell subpopulations were significantly higher in those patients who su ered clinical AbMR during the first 12 months after kidney transplantation. Similar results were observed in the prospective analysis of patients with subclinical antibody-mediated rejection detected in the surveillance biopsy performed at 12 months after kidney transplantation. A multivariate analysis confirmed the independent role of BAFF in the development of AbMR, irrespective of other classical variables. Pretransplant serum BAFF levels could be an important non-invasive biomarker for the prediction of the development of AbMR and posttransplant increased serum BAFF levels contribute to AbMR.

 Fuente: Int. J. Mol. Sci. 2020, 21, 779; doi:10.3390/ijms21030779

Editorial: MDPI

 Fecha de publicación: 25/01/2020

Nº de páginas: 18

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/ijms21030779

ISSN: 1661-6596,1422-0067

Url de la publicación: https://www.mdpi.com/1422-0067/21/3/779/htm

Autores/as

IRURE VENTURA, JUAN

SAN SEGUNDO, DAVID

EMILIO RODRIGO CALABIA

MERINO, DAVID

BELMAR VEGA, LARA

JUAN CARLOS RUIZ SAN MILLAN

VALERO, ROSALÍA

BENITO, ADALBERTO