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Multibranched Gold-Mesoporous Silica Nanoparticles Coated with a Molecularly Imprinted Polymer for Label-Free Antibiotic Surface-Enhanced Raman Scattering Analysis

Abstract: We describe the preparation of multibranched gold-silica -molecularly imprinted polymer (bAu@mSiO2@MIP) core-shell nanoparticles, with their specific ability to recognize enrofloxacin (ENRO), and their application as label-free nanosensors for the specific detection of the antimicrobial by surface-enhanced Raman scattering. The use of these nanocomposites results in a large enhancement of the Raman scattering of ENRO upon binding of an antibiotic to the selective recognition sites in the MIP. These are in the proximity of the gold core branches that act as intrinsic hot spots providing highly localized and strongly enhanced electromagnetic fields caused by plasmon resonance. The effect of the multibranched morphology of the gold cores (bAu) on the optical spectroscopic response of the bAu@mSiO2@MIP nanosensors is investigated with the aim of improving ENRO detection. The optimized nanostructures allowed us to achieve a detection limit of 1.5 nM for ENRO, which is 2 orders of magnitude lower than those for previously reported Au@MIP nanosensors, additionally providing negligible cross-reactivity toward other potential interfering species.

 Fuente: Chemistry of Materials. v. 28, issue 21 (2016), p. 7947-7954

Editorial: American Chemical Society

 Fecha de publicación: 17/10/2016

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1021/acs.chemmater.6b03613

ISSN: 0897-4756,1520-5002

Proyecto español: (CTQ2015-69278-C2-1R

Url de la publicación: https://doi.org/10.1021/acs.chemmater.6b03613

Autores/as

CARRASCO, SERGIO

BENITO-PEN?A, ELENA

NAVARRO-VILLOSLADA, FERNANDO

LANGER, JUDITH

REGUERA, JAVIER

LIZ-MARZAN, LUIS M.

MORENO-BONDI, MARÍA C.