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 Detalle_Publicacion

Surface Enhanced Raman Scattering and Gated Materials for Sensing Applications: The Ultrasensitive Detection of Mycoplasma and Cocaine

Abstract: We present herein a novel combination of gated mesoporous silica nanoparticles (MSNs) and surface-enhanced Raman scattering (SERS) for sensing applications. As a proof-of-concept, we show the design of a system comprising MSNs loaded with crystal violet (CV), a molecule with high Raman cross section acting as SERS reporter, and capped with either a suitable DNA sequence for the detection of Mycoplasma genomic DNA or with an aptamer that selectively coordinates cocaine. In both cases the presence of the corresponding target analyte in solution (i.e., genomic DNA or cocaine) resulted in the release of CV. CV delivery was detected by SERS upon adsorption on gold nanotriangles (AuNTs), which display an efficient electromagnetic field enhancement and a high colloidal stability. By using this novel procedure a limit of detection of at least 30 copies DNA per ?L was determined for the detection of Mycoplasma genomic DNA, whereas cocaine was detected at concentrations as low as 10 nm.

 Fuente: Chemistry - A European Journal, v. 22, iussue 38 (2016), p.13488 -13495

Editorial: Wiley-VCH Verlag

 Año de publicación: 2016

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1002/chem.201602457

ISSN: 0947-6539,1521-3765

Proyecto español: MAT2015-64139-C4-1-R MINECO/FEDER

Url de la publicación: https://doi.org/10.1002/chem.201602457

Autores/as

OROVAL, MAR

CORONADO-PUCHAU, MARC

LANGER, JUDITH

RIBES, ÁNGELA

AZNAR, ELENA

COLL, CARMEN

MARCOS, MARÍA DOLORES

SANCENÓN, FÉLIX

LIZ-MARZÁN, LUIS M.

MARTÍNEZ-MÁÑEZ, RAMÓN