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Brain grey matter abnormalities in first episode non-affective psychosis patients with suicidal behaviours: The role of neurocognitive functioning

Abstract: Background: Suicide is one of the leading causes of premature death in first-episode psychosis (FEP) patients. The understanding of suicidal behaviour (SB) is limited, and new and integrative approaches focusing on the likely relationship of the biological and cognitive features of SB in the early phases of psychosis are warranted. We aimed to study the relationship of brain grey matter anomalies and cognitive functioning with SB or suicidal risk in a large sample of non-affective FEP patients. Methods: We used a voxel-based morphometry analysis in 145 FEP patients to investigate the pattern of structural brain abnormalities related to SB. In addition, bivariate and multivariate analyses were performed to explore the relationship between cognitive functioning and SB. Results: A reduction in grey matter volume in the frontal area, temporal gyrus, precuneus, uncus, amygdala, left cuneus and subcallosal gyrus as well as a marked regional volume reduction in the right hemisphere was linked with the presence of SB. Additionally, worse global cognitive functioning and living in urban areas were identified as suicide risk factors. Conclusions: This study provides some insights about the brain abnormalities associated with SB in FEP patients. Specifically, the areas reported are involved in important functions related to SB, such as impulsivity, problem solving or responses to pain. Thus, the results confirm the relevant role of cognitive functioning on SB.

 Fuente: Progress in Neuropsychopharmacology & Biological Psychiatry 102 (2020) 109948

Editorial: Elsevier

 Fecha de publicación: 17/04/2020

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.pnpbp.2020.109948

ISSN: 0278-5846,1878-4216

Url de la publicación: https://doi.org/10.1016/j.pnpbp.2020.109948

Autores/as

CANAL RIVERO, MANUEL

TORDESILLAS GUTIÉRREZ, DIANA

RUIZ VEGUILLA, MIGUEL

ORTIZ GARCÍA DE LA FOZ, VICTOR

CUEVAS ESTEBAN, JORGE

ENRIQUE MARCO DE LUCAS

AYESA ARRIOLA, ROSA