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Duration of active psychosis during early phases of the illness and functional outcome: The PAFIP 10-year follow-up study

Abstract: Introduction: Longer duration of active psychosis (presence of positive psychotic symptoms) has been associated to worsening of functional and symptomatic outcome in patients with a first-episode of psychosis. There could be a "critical period" of increased brain vulnerability in the early phases of the illness when the effect of active psychosis would be exceptionally pernicious. Objectives: We aim to explore the impact of lengthy periods of active psychosis during early phases of illness on long-term functional outcome. Methods: This is a prospective clinical study. We assessed the effect of the duration active psychosis in patients with a first-episode of nonaffective psychosis on long-term social functioning and functional recovery. The study consisted of a 3-year clinical follow-up and a functional evaluation performed after a 10-year period. Results: The sample consisted of 169 patients with a first-episode of non-affective psychosis. The duration of active psychosis after treatment (DAT) during the 3-year clinical follow-up acted as predictor of social functioning at the 10-year functional evaluation (Wald: 10.705; p = .001), but not of functional recovery. The duration of untreated psychosis (DUP) did not act as a predictor of any of the two long-term measures of functional outcome. Conclusions: Active psychosis in early phases of the illness seems to be correlated to worst long-term functionality. In this study the duration of active psychosis after treatment (DAT) was a better predictor of long-term outcome than the duration of untreated psychosis (DUP). Reducing DAT should be considered an important objective for early intervention programs.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Schizophrenia Research Volume 220, June 2020, Pages 240-247

Editorial: Elsevier

 Fecha de publicación: 07/04/2020

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.schres.2020.03.009

ISSN: 0920-9964,1573-2509

Url de la publicación: https://doi.org/10.1016/j.schres.2020.03.009

Autores/as

PARDO DE SANTAYANA, GUILLERMO

GÓMEZ REVUELTA, MARCOS

AYESA ARRIOLA, ROSA

ORTIZ GARCIA DE LA FOZ, VICTOR

PELAYO TERÁN, JOSÉ MARÍA