Buscar

Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

High-sensitivity cardiac troponin T 30 days all-come mortality in patients with acute heart failure. A Propensity Score-Matching Analysis Based on the EAHFE Registry. TROPICA4 Study

Abstract: Background: Acute heart failure (AHF) patients with high troponin levels have a worse prognosis. High-sensitive troponin T (hs-TnT) has been used as a tool to stratify prognosis in many scales but always as a qualitative and not as a quantitative variable. Objectives: The main objective of this study was to determine the best hs-TnT cut-off for prediction of 30-day all-cause mortality. Methods: The EAHFE registry, a prospective follow-up cohort of patients with AHF, was analysed. We performed a propensity score analysis of the optimal hs-TnT cut-off point previously determined by receiver operating characteristic (ROC) curve analysis. Results: Of the 13 791 patients in the EAHFE cohort, we analysed 3190 patients in whom hs-TnT determination was available. The area under the ROC curve for 30-day all-cause mortality was 0.70 (CI95% 0.68 to 0.71; P < .001), establishing an optimal cut-off of hs-TnT of 35 ng/L. The sensitivity and specificity of this cut-off were 76.2 and 55.5%, respectively, with a negative predictive value (NPV) of 95.3%. A propensity score was made with 34 variables showing differences based on the cut-off of 35 ng/L for hs-TnT. In the analysis of the population obtained with the propensity score, patients with hs-TnT > 35 ng/L showed a greater 30-day all-cause mortality, with a HR of 2.95 (CI95% 1.83-4.75; P < .001). External validation reported similar results. Conclusions: An hs-TnT value of 35 ng/L is an adequate cut-off to evaluate the prediction of 30-day all-cause mortality with a NPV of 95.3%.

 Fuente: Eur J Clin Invest . 2020 Jun;50(6):e13248

Editorial: Springer

 Fecha de publicación: 01/06/2020

Nº de páginas: 11

Tipo de publicación: Artículo de Revista

 DOI: 10.1111/eci.13248

ISSN: 0014-2972,1365-2362

Url de la publicación: https://doi.org/10.1111/eci.13248

Autores/as

ROSET, ALEX

JACOB, JAVIER

HERRERO PUENTE, PABLO

ALQUÉZAR, AITOR

MARTÍN SÁNCHEZ, FRANCISCO JAVIER

LLORENS, PERE

GIL, VICTOR

CABELLO, IRENE

RICHARD, FERNANDO

GARRIDO, JOSE MANUEL

GIL, CRISTINA

LLAUGER, LLUIS

WUSSLER, DESIREE

MUELLER, CHRISTIAN

MIRÓ, ÒSCAR

ICA-SEMES RESEARCH GROUP