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Dissecting the functional outcomes of first episode schizophrenia spectrum disorders: a 10-year follow-up study in the PAFIP cohort

Abstract: Background. The aim of the current study was to examine the heterogeneity of functional outcomes in first episode psychosis (FEP) patients and related clinical, neurocognitive and sociodemographic factors using a cluster analytic approach. Method. A large sample of FEP patients (N = 209) was functionally reassessed 10 years after the first contact with an early intervention service. Multiple baseline, 3-year and 10-year follow- up variables were explored. Results. The cluster analysis emphasized the existence of six independent clusters of functioning: one cluster was normal overall (42.16%), two clusters showed moderate interpersonal (9.63%) or instrumental (12.65%) deficits, two clusters showed more severe interpersonal (12.05%) or interpersonal and instrumental (13.85%) deficits and there was a significantly overall impaired cluster (9.63%). Cluster comparisons showed that several baseline and follow- up factors were differentially involved in functional outcomes. Conclusions. The current study demonstrated that distinct clusters of functioning in FEP patients can be identified. The fact that a variety of profiles was observed contributes to a better understanding of the nature of the heterogeneity characterizing FEP patients and has clinical implications for developing individualized treatment plans.

 Fuente: Psychological Medicine, 51(2), 264-277

Editorial: Cambridge University Press

 Fecha de publicación: 01/01/2021

Nº de páginas: 14

Tipo de publicación: Artículo de Revista

 DOI: 10.1017/S0033291719003179

ISSN: 0033-2917,1469-8978

Autores/as

AYESA ARRIOLA, ROSA

ORTÍZ GARCÍA DE LA FOZ, VÍCTOR

MARTÍNEZ GARCÍA, OBDULIA

SETIÉN SUERO, ESTHER

RAMÍREZ, MARÍA LUZ

MAYORAL VAN SON, JAQUELINE

JUNCAL RUIZ, MARÍA

GÓMEZ REVUELTA, MARCOS

TORDESILAS GUTIÉRREZ, DIANA