Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

Antiphospholipid syndrome and antiphospholipid antibody profile in patients with retinal vein occlusion

Abstract: Introduction: Data on prevalence, association with vascular risk factors, clinical management and outcome of antiphospholipid syndrome (APS) in retinal vein occlusion (RVO) are scarce. Methods: Patients diagnosed with RVO at a tertiary-care hospital, and two additional groups; population-based controls and patients with APS (RVO-APS) were studied. Prevalence, association with vascular risk factors, antiphospholipid antibody profile, clinical management, genetic thrombophilia profile, carotid ultrasound and outcome of RVO-APS patients were assessed and compared with controls. Results: Some 331 consecutive patients with RVO and 281 controls were included. Overall, aPLs were more prevalent in RVO-patients than in controls (33, 10% vs. 12, 4.3%; adjusted OR 2.47; 95% CI 1.25-4.88; p = 0.009). Patients with RVO-APS showed a high-risk "aPL profile" (lupus anticoagulant or triple-positive). We did not find any difference regarding classic vascular risk factors, hyperhomocysteinemia, prior vascular events, and carotid plaque, in RVO-patients with or without APS. The phenotype of RVO-APS also differed from APS. Seven patients received anticoagulation and 24 were on low-dose aspirin. After a median follow-up of 62 months, 7 patients suffered a RVO relapse (4 of them had APLs) and no RVO-APS patient had a new thrombotic or vascular event outside the retina. Conclusions: aPLs were more prevalent in RVO-patients than in controls, and in all patients, APS was not associated with any connective-tissue disease. RVO in the setting of APS seems not only related to atherosclerosis, but also to the "aPL profile". In most of our RVO-patients with APS, low-dose aspirin was effective to prevent new or recurrent thrombotic events outside the retinal vessels. In these patients, we suggest that RVO could behave as an organ-specific manifestation of APS.

 Fuente: Thromb Res . 2020 Jun;190:63-68

Editorial: Elsevier

 Año de publicación: 2020

Nº de páginas: 6

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.thromres.2020.04.005

ISSN: 0049-3848,1879-2472

Url de la publicación: https://doi.org/10.1016/j.thromres.2020.04.005

Autores/as

Mª DEL ROCIO PEREZ MONTES

ZAIDA SALMON GONZALEZ

SIERRA, ISABEL

ESCALANTE, ESTEFANÍA

JOSE JAVIER NAPAL LECUMBERRI