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Treatment discontinuation impact on long-term (10-years) weight gain and lipid metabolism in first-episode psychosis: results from the PAFIP-10 cohort

Abstract: Background: patients with a first episode of psychosis (FEP) are at higher risk of gaining weight and presenting metabolic disturbances, partly related to antipsychotic exposure. Previous studies suggest that treatment discontinuation might have a positive impact on weight in schizophrenia. The aim of this study was to evaluate the effect of treatment discontinuation on weight and metabolic changes in a FEP cohort. Methods: a total of 209 FEP patients and 57 healthy controls were evaluated at study entry and prospectively at 10-year follow-up. Anthropometric measures and, clinical, metabolic, and sociodemographic data were collected. Results: patients discontinuing antipsychotic treatment presented a significantly lower increase in weight and better metabolic parameter results than those still on antipsychotic treatment at 10-year follow-up. Conclusions: treatment discontinuation had a positive effect on the weight and metabolic changes observed in FEP patients; however, this effect was not sufficient to reaching a complete reversal to normal levels.

 Fuente: International Journal of Neuropsychopharmacology, Volume 24, Issue 1, January 2021, Pages 1-7

Editorial: Oxford University Press

 Fecha de publicación: 01/01/2021

Nº de páginas: 7

Tipo de publicación: Artículo de Revista

 DOI: 10.1093/ijnp/pyaa066

ISSN: 1461-1457,1469-5111

Url de la publicación: https://academic.oup.com/ijnp/article/24/1/1/5897000

Autores/as

MAYORAL VAN SON, JAQUELINE

GÓMEZ REVUELTA, MARCOS

JUNCAL RUIZ, MARÍA

ORTIZ GARCÍA DE LA FOZ, VÍCTOR

TORDESILLAS GUTIÉRREZ, DIANA

AYESA ARRIOLA, ROSA

BIOQUE, MIQUEL

CRESPO FACORRO, BENEDICTO