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Abstract: Background: patients with a first episode of psychosis (FEP) are at higher risk of gaining weight and presenting metabolic disturbances, partly related to antipsychotic exposure. Previous studies suggest that treatment discontinuation might have a positive impact on weight in schizophrenia. The aim of this study was to evaluate the effect of treatment discontinuation on weight and metabolic changes in a FEP cohort.
Methods: a total of 209 FEP patients and 57 healthy controls were evaluated at study entry and prospectively at 10-year follow-up. Anthropometric measures and, clinical, metabolic, and sociodemographic data were collected.
Results: patients discontinuing antipsychotic treatment presented a significantly lower increase in weight and better metabolic parameter results than those still on antipsychotic treatment at 10-year follow-up.
Conclusions: treatment discontinuation had a positive effect on the weight and metabolic changes observed in FEP patients; however, this effect was not sufficient to reaching a complete reversal to normal levels.
Fuente: International Journal of Neuropsychopharmacology, Volume 24, Issue 1, January 2021, Pages 1-7
Editorial: Oxford University Press
Fecha de publicación: 01/01/2021
Nº de páginas: 7
Tipo de publicación: Artículo de Revista
Url de la publicación: https://academic.oup.com/ijnp/article/24/1/1/5897000
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JAVIER VAZQUEZ BOURGON
MAYORAL VAN SON, JAQUELINE
GÓMEZ REVUELTA, MARCOS
JUNCAL RUIZ, MARÍA
ORTIZ GARCÍA DE LA FOZ, VÍCTOR
TORDESILLAS GUTIÉRREZ, DIANA
AYESA ARRIOLA, ROSA
CRESPO FACORRO, BENEDICTO